Nature Search

Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Elevated extrinsic tissue-scale forces can drive pathological foreign-body responses to implants, mediated by the Rac2-mediated activation of a subpopulation of mechanoresponsive myeloid cells.

Jagannath Padmanabhan
Kellen Chen
Geoffrey C. Gurtner
ResearchOpen Access25 Sept 2023
Nature Biomedical Engineering

Volume: 7, P: 1419-1436
Pervasive increase in tree mortality across the Australian continent

Eight decades of forest plot monitoring show a pervasive increase in tree mortality across Australia’s forest biomes driven by climate change, jeopardizing their role as enduring carbon sinks.

Ruiling Lu
Laura J. Williams
Belinda E. Medlyn
Research06 Jan 2026
Nature Plants

Volume: 12, P: 62-73
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma

The composition of extracellular vesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform proteomic and lipidomic analyses of circulating human plasma EVs and create a web tool for data exploration.

Alin Rai
Kevin Huynh
David W. Greening
ResearchOpen Access28 Nov 2025
Nature Cell Biology

Volume: 27, P: 2167-2185
Dietary thiaminase alters morphology and decreases swimming performance of lake trout (Salvelinus namaycush)

Christian A. Therrien
Peter M. Baker
Bryan D. Neff
ResearchOpen Access19 Jan 2026
Scientific Reports

P: 1-12
Multi-omic analysis of human PHACTR1 signaling networks

Integrated multi-omics analysis uncovers the role of the vascular disease-associated gene PHACTR1 in regulating mitochondrial dynamics, iron metabolism, and cell cycle.

Kathryn Wolhuter
Lijiang Ma
Jason C. Kovacic
ResearchOpen Access19 Jan 2026
Communications Biology

P: 1-22
Current protected areas provide limited benefits for European river biodiversity

The effects of current protected areas on freshwater biodiversity are poorly understood. Here, the authors show that European protected areas have overall limited influence on changes in river biodiversity, underscoring the urgent need for improved effectiveness.

James S. Sinclair
Rachel Stubbington
Peter Haase
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 16, P: 1-11
Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

As presented at the ESMO Congress 2025: Results of the phase 2/3 AGITG DYNAMIC-III trial show that de-escalated chemotherapy based on ctDNA-negative status in patients with stage III colon cancer did not meet non-inferiority for 3-year recurrence-free survival when compared to standard of care, although it enables better informed treatment decisions.

Jeanne Tie
Yuxuan Wang
Petr Kavan
Research20 Oct 2025
Nature Medicine

Volume: 31, P: 4291-4300
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Rewiring of cortical glucose metabolism fuels human brain cancer growth

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Andrew J. Scott
Anjali Mittal
Daniel R. Wahl
ResearchOpen Access03 Sept 2025
Nature

Volume: 646, P: 413-422
Reassessing the dependence of cloud condensation nucleus concentration on formation rate

Andrew S. Ackerman
Owen B. Toon
Peter V. Hobbs
Research03 Feb 1994
Nature

Volume: 367, P: 445-447
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Intrinsic muscle stem cell dysfunction underlies functional deficits in models of type 1 diabetes

Jin D. Chung
Jennifer Trieu
Gordon S. Lynch
ResearchOpen Access06 Jan 2026
npj Regenerative Medicine

P: 1-14
Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote

Horizontally transferred genes must be integrated into host biology. Here, the authors show that the domestication of bacterial hopanoid synthesis has rewired lipid metabolism of a eukaryote leading to changes in membrane structure and physiology.

Bhagyashree Dasari Rao
Elisa Gomez-Gil
Snezhana Oliferenko
ResearchOpen Access07 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones

The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

A. M. Mahedi Hasan
Paolo Cremaschi
Gerhardt Attard
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Lipid pathways connecting maternal BMI with infant obesity risk

Alexandra D. George
Tingting Wang
Peter J. Meikle
ResearchOpen Access30 Dec 2025
Scientific Reports

Volume: 16, P: 1-10
Ophiolites in south-western Newfoundland

Peter A. Brown
Research23 Dec 1976
Nature

Volume: 264, P: 712-715
Metabolic Pathways of Red Blood Cell Copper in Normal Humans and in Wilson's Disease

PETER Z. NEUMANN
MERVIN SILVERBERG
Research25 Feb 1967
Nature

Volume: 213, P: 775-779
The Microflora Danica atlas of Danish environmental microbiomes

Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

C. M. Singleton
T. B. N. Jensen
M. Albertsen
ResearchOpen Access03 Dec 2025
Nature

Volume: 649, P: 971-981
Effect of climate on traits of dominant and rare tree species in the world’s forests

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Iris Hordijk
Lourens Poorter
Thomas W. Crowther
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-15
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Pesticides in rainwater in the northeastern United States

R. Peter Richards
Jack W. Kramer
Kenneth A. Krieger
Research14 May 1987
Nature

Volume: 327, P: 129-131
Vasopressins and the Increase of Water and Electrolyte Excretion by Sheep, Cattle and Camels

W. V. MACFARLANE
R. KINNE
D. PETER
Research01 Jun 1967
Nature

Volume: 214, P: 979-981
New Miocene locality in Turkey with evidence on the origin of Ramapithecus and Sivapithecus

Peter Andrews
H. Tobien
Research25 Aug 1977
Nature

Volume: 268, P: 699-701
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
New Guinea has the world’s richest island flora

A catalogue of the vascular flora of New Guinea indicates that this island is the most floristically diverse in the world, and that 68% of the species identified are endemic to New Guinea.

Rodrigo Cámara-Leret
David G. Frodin
Peter C. van Welzen
Research05 Aug 2020
Nature

Volume: 584, P: 579-583
Imputation of plasma lipid species to facilitate integration of lipidomic datasets

Advancements in plasma lipidomic profiling increase specificity of measurements but pose challenges in aligning datasets created at different times or platforms. Here the authors present a predictive framework for harmonising such datasets with different levels of granularity in their lipid measurements.

Aleksandar Dakic
Jingqin Wu
Peter J. Meikle
ResearchOpen Access20 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Direct linkage of epidermal growth factor to its receptor

PETER S. LINSLEY
CINDY BLIFELD
C. FRED Fox
Research01 Apr 1979
Nature

Volume: 278, P: 745-748
Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity

An ultra-low-input single-cell proteomic workflow is optimized to yield maximum proteome coverage with high accuracy and precision on the Orbitrap Astral mass spectrometer.

Julia A. Bubis
Tabiwang N. Arrey
Manuel Matzinger
ResearchOpen Access16 Jan 2025
Nature Methods

Volume: 22, P: 510-519
Solution structure of the origin DNA-binding domain of SV40 T-antigen

Xuelian Luo
David G. Sanford
William W. Bachovchin
Research01 Dec 1996
Nature Structural Biology

Volume: 3, P: 1034-1039
Critical elements in proteasome assembly

Peter Zwickl
Jörg Kleinz
Wolfgang Baumeister
Research01 Nov 1994
Nature Structural Biology

Volume: 1, P: 765-770
Isolation and characterisation of the φX174 ribosome binding sites

Jeffrey V. Ravetch
Peter Model
Hugh D. Robertson
Research24 Feb 1977
Nature

Volume: 265, P: 698-702
Catalytically grown carbon filaments from a smelter aerosol

John P. Bradley
Peter R. Buseck
Research22 Dec 1983
Nature

Volume: 306, P: 770-772
Gene loss and compensatory evolution promotes the emergence of morphological novelties in budding yeast

The role of compensatory mutations in phenotypic evolution is unclear. Here the authors use experimental evolution to show that gene loss followed by compensatory evolution contributes to the rapid emergence of new cellular and multicellular morphologies in the budding yeast.

Zoltán Farkas
Károly Kovács
Balázs Papp
Research28 Apr 2022
Nature Ecology & Evolution

Volume: 6, P: 763-773
Eichornia crassipes in the Nile of the Sudan

PETER A. GAY
Research23 Aug 1958
Nature

Volume: 182, P: 538-539
Triplet Nucleotide–Amino-acid Pairing; a Stereo-chemical Basis for the Division between Protein and Non-protein Amino-acids

PETER DUNNILL
Research18 Jun 1966
Nature

Volume: 210, P: 1267-1268
Interactions between the lipidome and genetic and environmental factors in autism

Detailed analyses pairing deep phenotyping and molecular profiles reveal mediating roles of plasma lipids in genetic and environmental factors associated with autism-related traits in children.

Chloe X. Yap
Anjali K. Henders
Jacob Gratten
ResearchOpen Access19 Apr 2023
Nature Medicine

Volume: 29, P: 936-949
Anterior and posterior compartments in the head of Drosophila

GINES MORATA
PETER A. LAWRENCE
Research03 Aug 1978
Nature

Volume: 274, P: 473-474
Nautiloid growth rhythms and lunar dynamics (reply)

STEPHEN M. POMPEA
PETER G. K. KAHN
Research01 May 1979
Nature

Volume: 279, P: 455-456
Increasing tree size across Amazonia

A global research network monitoring the Amazon for 30 years reports in this study that tree size increased by 3% each decade.

Adriane Esquivel-Muelbert
Rebecca Banbury Morgan
Oliver L. Phillips
ResearchOpen Access25 Sept 2025
Nature Plants

Volume: 11, P: 2016-2025
Is stimulation of benzodiazepine receptor binding mediated by a novel GABA receptor?

MANFRED KAROBATH
PETER PLACHETA
POVL KROGSGAARD LARSEN
Research01 Apr 1979
Nature

Volume: 278, P: 748-749
Building the Australian Cardiovascular disease Data Commons

In this Tools of the Trade article, Giles and Meikle describe the development of the the Australian Cardiovascular disease Data Commons, which provides a comprehensive, secure, scalable and internationally integrated database containing pooled data from approximately 400,000 individuals in Australia.

Corey Giles
Peter J. Meikle
Research Highlights02 Sept 2025
Nature Reviews Cardiology

Volume: 22, P: 837
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

Dysregulation of lipid metabolism is associated with coronary artery disease (CAD). Here, the authors perform GWAS of the serum lipidome to identify variants associated with lipid species that are putatively in the mechanistic pathway to CAD.

Gemma Cadby
Corey Giles
Eric K. Moses
ResearchOpen Access06 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Retraction Note: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

Hanh Chi Do-Umehara
Cong Chen
Jing Liu
Amendments and Corrections07 Jan 2025
Nature Immunology

Volume: 26, P: 324
Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle

Bond et al. show that inducible PolG mutation in muscle causes mtDNA damage and muscle wasting. This is driven by the integrated stress response (ISR) and reduction in folate intermediates, linking impaired folate metabolism with ISR/disease induction.

Simon T. Bond
Emily J. King
Brian G. Drew
ResearchOpen Access08 Mar 2025
Nature Communications

Volume: 16, P: 1-21
An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12

Chen Keasar
Liam J. McGuffin
Silvia N. Crivelli
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-18
Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts

A substantial proportion of patients with cardiometabolic conditions appear to have normal BMI. Conversely, not all obese individuals exhibit these disorders. Here, we show that a metabolic BMI score derived from lipidomic models, allows quantify metabolic dysregulation in obesity independently of BMI.

Habtamu B. Beyene
Corey Giles
Peter J. Meikle
ResearchOpen Access07 Oct 2023
Nature Communications

Volume: 14, P: 1-19
Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

Whole genome sequencing is increasingly being adopted for Shigella sonnei outbreak investigation and surveillance, but there is no global classification standard. Here, the authors develop and validate a genomic framework implemented using open-source software, and demonstrate its application using surveillance data.

Jane Hawkey
Kalani Paranagama
Kathryn E. Holt
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-12

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