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Showing 1–50 of 94 results

Advanced filters: Author: Peter D. Sly Clear advanced filters

Calpain silencing by a reversible intrinsic mechanism

Tudor Moldoveanu
Christopher M. Hosfield
Peter L. Davies
Research31 Mar 2003
Nature Structural & Molecular Biology

Volume: 10, P: 371-378
Long–term protection against SIV–induced disease in macaques vaccinated with a live attenuated HIV–2 vaccine

Per Putkonen
Lilian Walther
Gunnel Biberfeld
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 914-918
Acidification of the male reproductive tract by a proton pumping(H⁺)-ATPase

Sylvie Breton
Peter J.S. Smith
Dennis Brown
Research01 Apr 1996
Nature Medicine

Volume: 2, P: 470-472
Strategies for blood–brain barrier rejuvenation and repair

The blood–brain barrier (BBB) is a dynamic interface that tightly regulates the transport of substances from the blood into the brain. BBB dysfunction can occur with ageing and is a hallmark of many major diseases but is underappreciated as a therapeutic target. Here, Searson and Banks review studies on BBB repair and rejuvenation, highlighting common mechanisms across disorders and potential strategies for pharmacological intervention.

Peter C. Searson
William A. Banks
Reviews28 Jan 2026
Nature Reviews Drug Discovery

P: 1-22
Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques

Mamoru Watanabe
Keith A. Reimann
Norman L. Letvin
Research19 Jan 1989
Nature

Volume: 337, P: 267-270
Glucose Metabolism Via The Pentose Phosphate Pathway Relative to Cell Replication and Immunological Response

PETER BEACONSFIELD
JEAN GINSBURG
Z. KOSINSKI
Research01 Jan 1965
Nature

Volume: 205, P: 50-51
Human infection by genetically diverse SIV_SM-related HIV-2 in West Africa

Feng Gao
Ling Yue
Beatrice H. Hahn
Research06 Aug 1992
Nature

Volume: 358, P: 495-499
Ready-to-use iPSC-derived microglia progenitors for the treatment of CNS disease in mouse models of neuropathic mucopolysaccharidoses

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by enzyme deficiencies leading to glycosaminoglycan accumulation and systemic degenerative disease. Here, the authors show that iPSC-derived microglia progenitors can reduce glycosaminoglycan accumulation and prevent behavioral deficits in MPS mouse models.

Panagiotis Douvaras
Diego F. Buenaventura
Stefan Irion
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-21
A homozygous stop codon in the lysyl hydroxylase gene in two siblings with Ehlers–Danlos syndrome type VI

James Hyland
Leena Ala-Kokko
Raili Myllylä
Research01 Nov 1992
Nature Genetics

Volume: 2, P: 228-231
Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1 /Fas) Mediated apoptosis

Susanne Strand
Walter J. Hofmann
Peter R. Galle
Research01 May 1998
Nature Medicine

Volume: 4, P: 588-593
β-Glucuronidase Deficiency in a Dog: a Model of Human Mucopolysaccharidosis VII

Mark E Haskins
Robert J Desnick
Donald F Patterson
Research01 Oct 1984
Pediatric Research

Volume: 18, P: 980-984
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

Edwina Wright
Murray R. Hargrave
Peter Koopman
Research01 Jan 1995
Nature Genetics

Volume: 9, P: 15-20
Alpha-L-iduronidase Deficiency in a Cat: A Model of Mucopolysaccharidosis I

Mark E Haskins
Peter F Jezyk
Donald F Patterson
Research01 Nov 1979
Pediatric Research

Volume: 13, P: 1294-1297
Receding hopes of AIDS vaccines

Prospects that there will soon be an effective vaccine against HIV are diminishing. In the absence of a good animal model of AIDS, direct human trials of candidate vaccines are inevitable.

Peter Newmark
News & Views23 Jun 1988
Nature

Volume: 333, P: 699
Pathways to secretion

Peter Newmark
News & Views25 Oct 1979
Nature

Volume: 281, P: 629-630
Hypoxanthine, Xanthine, and Uric Acid Concentrations in the Cerebrospinal Fluid, Plasma, and Urine of Hypoxemic Pigs

Jan Peter Poulsen
Stephanie Øyasæter
Ola Didrik Saugstad
Research01 Nov 1990
Pediatric Research

Volume: 28, P: 477-481
Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions

Fandan Meng
Nai-Huei Wu
Peter Valentin-Weigand
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-13
Transglutaminase is essential in receptor-mediated endocytosis of α₂-macroglobulin and polypeptide hormones

Peter J. A. Davies
Dana R. Davies
Ira H. Pastan
Research10 Jan 1980
Nature

Volume: 283, P: 162-167
A mouse model for Zellweger syndrome

Myriam Baes
Pierre Gressens
Guy P. Mannaerts
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 49-57
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

Richard Rozmahe
Michael Wilschanski
Lap-Chee Tsui
Research01 Mar 1996
Nature Genetics

Volume: 12, P: 280-287
Dependence of Intrapulmonary Pressure Amplitudes on Respiratory Mechanics during High-Frequency Oscillatory Ventilation in Preterm Lambs

J Jane Pillow
Peter D Sly
Jason H T Bates
Research01 Oct 2002
Pediatric Research

Volume: 52, P: 538-544
The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

Peter C. Bull
Gordon R. Thomas
Diane Wilson Cox
Research01 Dec 1993
Nature Genetics

Volume: 5, P: 327-337
Mammalian and bacterial sugar transport proteins are homologous

Martin C. J. Maiden
Elaine O. Davis
Peter J. F. Henderson
Research18 Feb 1987
Nature

Volume: 325, P: 641-643
Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site

Gordon V. Louie
Paul D. Brownlie
Peter M. Jordan
Research03 Sept 1992
Nature

Volume: 359, P: 33-39
Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts

David M. Lawson
Peter J. Artymiuk
Pauline M. Harrison
Research07 Feb 1991
Nature

Volume: 349, P: 541-544
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

Annemieke de Vries
Conny Th. M. van Oostrom
Sjef J. Verbeek
Research14 Sept 1995
Nature

Volume: 377, P: 169-173
Prenatal and birth factors associated with child autism diagnosis: a birth cohort perspective

Lada Holland
Katherine Drummond
Martin O’Hely
ResearchOpen Access15 Jan 2026
Pediatric Research

P: 1-14
Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype

Prenatal bisphenol A exposure is associated with an increased risk of ASD in boys through a mechanism involving aromatase suppression. These resulting ASD-related behaviors and brain abnormalities may be reversed through postnatal intervention with 10HDA in mice.

Christos Symeonides
Kristina Vacy
Wah Chin Boon
ResearchOpen Access07 Aug 2024
Nature Communications

Volume: 15, P: 1-22
Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8

Samuel E. Lux
William T. Tse
Bernard G. Forget
Research21 Jun 1990
Nature

Volume: 345, P: 736-739
Complexities and strategies

Peter Newmark
News & Views19 Oct 1989
Nature

Volume: 341, P: 566-567
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression

Jacob L Mueller
Shantha K Mahadevaiah
James M A Turner
Research04 May 2008
Nature Genetics

Volume: 40, P: 794-799
Markedly Reduced Activity of Lysyl Oxidase in Skin and Aorta from a Patient with Menkes' Disease Showing Unusually Severe Connective Tissue Manifestations

Peter M Royce
Beat Steinmann
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 137-141
Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Incidence of food allergy in westernized populations is associated with low abundance of Prevotella. Here, the authors analyse the microbiome of a mother-infant prebirth cohort and find that maternal carriage, but not infant carriage, of P. copri during pregnancy predicts the absence of food allergy in the offspring.

Peter J. Vuillermin
Martin O’Hely
Esther Bandala Sanchez
ResearchOpen Access24 Mar 2020
Nature Communications

Volume: 11, P: 1-7
Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.

Mingjing Hu
David Eviston
Ralph Nanan
ResearchOpen Access10 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

Harris D. Bernstein
Mark A. Poritz
Peter Walter
Research10 Aug 1989
Nature

Volume: 340, P: 482-486
Molecular Analysis of Cystinosis: Probable Irish Origin of the Most Common French Canadian Mutation

Jean McGowan-Jordan
Karen Stoddard
Hans Heick
Research01 Sept 1999
European Journal of Human Genetics

Volume: 7, P: 671-678
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.

Louise V Wain
Nick Shrine
Martin D Tobin
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 416-425
A translocation interrupts the COL5A1 gene in a patient with Ehlers–Danlos syndrome and hypomelanosis of Ito

Helga V. Toriello
Thomas W. Glover
Daniel S. Greenspan
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 361-365
Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells

Hayden Holmlund
Manon Coulée
Monika A. Ward
ResearchOpen Access27 Aug 2025
Cell Death & Differentiation

P: 1-19
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Ashley Budu-Aggrey
Anna Kilanowski
Lavinia Paternoster
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Effect of Salbutamol on Respiratory Mechanics in Bronchiolitis

Daniel M Hughes
Peter N Lesouëf
Louis I Landau
Research01 Jul 1987
Pediatric Research

Volume: 22, P: 83-86
Partitioning of Airway and Parenchymal Mechanics in Unsedated Newborn Infants

J Jane Pillow
Janet Stocks
Zoltán Hantos
Research01 Dec 2005
Pediatric Research

Volume: 58, P: 1210-1215
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers.

Ivan T. Lee
Tsuguhisa Nakayama
Peter K. Jackson
ResearchOpen Access28 Oct 2020
Nature Communications

Volume: 11, P: 1-14
In Vivo Measurements of Changes in Respiratory Mechanics with Age in Mice Deficient in Surfactant Protein D

Rachel A Collins
Machiko Ikegami
Peter D Sly
Research01 Mar 2003
Pediatric Research

Volume: 53, P: 463-467
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk

Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs and response eQTLs to various stimuli in neonatal myeloid cells and T cells, and revealed their potential role in immune-mediated diseases using colocalisation and Mendelian randomisation.

Qin Qin Huang
Howard H. F. Tang
Michael Inouye
ResearchOpen Access28 Jul 2020
Nature Communications

Volume: 11, P: 1-12
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Martin Tobin and colleagues report a meta-analysis of 23 genome-wide association studies for pulmonary function. They identify 16 loci newly associated with variation in two cross-sectional measures of lung function, used to define airway obstruction and to grade the severity of obstruction.

María Soler Artigas
Daan W Loth
Martin D Tobin
Research25 Sept 2011
Nature Genetics

Volume: 43, P: 1082-1090
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

In HIV research, new types of reagents are needed to target infected cells and overcome HIV's ability to vary its HLA-I-restricted antigens and escape from host cytotoxic T lymphocytes. Here Varela-Rohena and colleagues use phage display technology to generate high-affinity T-cell antigen receptors that recognize common epitope-escape variants of the immunodominant HLA-A^*02-restricted, HIVgag-specific peptide SLYNTVATL (SL9).

Angel Varela-Rohena
Peter E Molloy
James L Riley
Research09 Nov 2008
Nature Medicine

Volume: 14, P: 1390-1395
Meta-analysis identifies seven susceptibility loci involved in the atopic march

The development of asthma following eczema is known as the atopic march. Here the authors conduct a GWAS on affected children and identify two novel loci associated with the disease phenotype.

Ingo Marenholz
Jorge Esparza-Gordillo
Young Ae Lee
ResearchOpen Access06 Nov 2015
Nature Communications

Volume: 6, P: 1-8
Antenatal Endotoxin and Glucocorticoid Effects on Lung Morphometry in Preterm Lambs

Karen E Willet
Alan H Jobe
Peter D Sly
Research01 Dec 2000
Pediatric Research

Volume: 48, P: 782-788
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bønnelykke and colleagues report results of a genome-wide association study of allergic sensitization. They identify ten loci influencing this phenotype and provide insight into the shared genetic basis of allergic sensitization and atopic diseases.

Klaus Bønnelykke
Melanie C Matheson
A John Henderson
Research30 Jun 2013
Nature Genetics

Volume: 45, P: 902-906

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