Nature Search

Virulence on Pm4 kinase-based resistance is determined by two divergent wheat powdery mildew effectors

AvrPm4 is a chimeric powdery mildew effector that is recognized by the wheat kinase fusion resistance protein Pm4. The pathogen can evade Pm4 recognition by expressing the suppressor SvrPm4, an RNase-like effector with multiple roles.

Zoe Bernasconi
Aline G. Herger
Beat Keller
ResearchOpen Access12 Jan 2026
Nature Plants

Volume: 12, P: 164-178
A decomposition of book structure through ousiometric fluctuations in cumulative word-time

Mikaela Irene Fudolig
Thayer Alshaabi
Peter Sheridan Dodds
ResearchOpen Access29 Apr 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-12
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
New biological activity following intravascular activation of the complement cascade

CHARLES E. MCCALL
LAWRENCE R. DE CHATELET
PETER LACHMANN
Research28 Jun 1974
Nature

Volume: 249, P: 841-843
A Cu(I)-semiquinone state in substrate-reduced amine oxidases

David M. Dooley
Michele A. McGuirl
Peter F. Knowles
Research17 Jan 1991
Nature

Volume: 349, P: 262-264
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Subtle structural alterations in the chains of type I procollagen produce osteogenesis imperfecta type II

Jeffrey Bonadio
Peter H. Byers
Research25 Jul 1985
Nature

Volume: 316, P: 363-366
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Nuclear exchange generates population diversity in the wheat leaf rust pathogen Puccinia triticina

Sperschneider et al. generate nuclear-assigned genome assemblies for several isolates of the wheat leaf rust pathogen, Puccinia triticina, and show that repeated nuclei shuffling between clonal lineages has created global populations.

Jana Sperschneider
Tim Hewitt
Melania Figueroa
ResearchOpen Access26 Oct 2023
Nature Microbiology

Volume: 8, P: 2130-2141
Anthropogenic nutrient inputs cause excessive algal growth for nearly half the world’s population

Human impact has increased total nitrogen and phosphorus concentrations over reference conditions and doubled the areas affected by potentially harmful algal growth, impacting around 40% of the global population.

Richard W. McDowell
Dongwen Luo
Walter K. Dodds
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Happiness and the Patterns of Life: A Study of Geolocated Tweets

Morgan R. Frank
Lewis Mitchell
Christopher M. Danforth
ResearchOpen Access12 Sept 2013
Scientific Reports

Volume: 3, P: 1-9
The extremophile Nicotiana benthamiana has traded viral defence for early vigour

The viral hypersensitivity of Nicotiana benthamiana results from an insertion in the RNA polymerase, Rdr1. Population analyses showed that the Rdr1 insertion originated from a population that trades viral defence for vigour in an extreme Australian habitat.

Julia Bally
Kenlee Nakasugi
Peter M. Waterhouse
Research02 Nov 2015
Nature Plants

Volume: 1, P: 1-6
Emergence of the Ug99 lineage of the wheat stem rust pathogen through somatic hybridisation

Strain Ug99 of the wheat stem rust pathogen, Puccinia graminis f. sp. tritici, is a major threat to global food security. Here, the authors present genomic analyses supporting that Ug99 arose as a result of non-sexual genetic exchange between dikaryotic ancestors.

Feng Li
Narayana M. Upadhyaya
Melania Figueroa
ResearchOpen Access07 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease.

Felicity Newell
Yan Kong
Richard A. Scolyer
ResearchOpen Access18 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity

Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.

Felicity Newell
James S. Wilmott
Nicholas K. Hayward
ResearchOpen Access16 Oct 2020
Nature Communications

Volume: 11, P: 1-14
Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9

Among all wheat rust resistance genes, SR9 has the largest number of alleles. Here, the authors use gene cloning, complementation and comparative genetics to resolve the relationship among Sr9 alleles, confirm their allelic identities, and show that a single amino acid change leads to resistance to Ug99.

Jianping Zhang
Jayaveeramuthu Nirmala
Evans Lagudah
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-12
The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus

Wheat stem rust is a devastating fungal disease, especially since the emergence of the virulent Ug99 lineage. An efficient resistance gene, encoding a CC–NB–LRR, is identified in a highly diverse locus of rye, and is effective against Ug99.

Rohit Mago
Peng Zhang
Peter N. Dodds
Research30 Nov 2015
Nature Plants

Volume: 1, P: 1-3
The case for an open Universe

Peter Coles
George Ellis
Reviews25 Aug 1994
Nature

Volume: 370, P: 609-615
Spontaneous change of a benign satellite RNA of cucumber mosaic virus to a pathogenic variant

Peter Palukaitis
Marilyn J. Roossinck
Research01 Oct 1996
Nature Biotechnology

Volume: 14, P: 1264-1268
Pooled effector library screening in protoplasts rapidly identifies novel Avr genes

The authors developed a platform for rapid identification of interacting plant immune receptors and pathogen avirulence proteins by library screening in protoplasts, then used it to identify new wheat stem rust Avr genes recognized by known wheat resistance genes.

Taj Arndell
Jian Chen
Peter N. Dodds
ResearchOpen Access26 Feb 2024
Nature Plants

Volume: 10, P: 572-580
Correlation Analysis of the Anterolateral Ligament Length with the Anterior Cruciate Ligament Length and Patient’s Height: An Anatomical Study

Gloria M. Hohenberger
Marco Maier
Patrick Sadoghi
ResearchOpen Access05 Jul 2019
Scientific Reports

Volume: 9, P: 1-8
Collective sleep and activity patterns of college students from wearable devices

Mikaela Irene Fudolig
Laura S. P. Bloomfield
Christopher M. Danforth
ResearchOpen Access07 Nov 2025
npj Complexity

Volume: 2, P: 1-10
Plant immunity: towards an integrated view of plant–pathogen interactions

Our understanding of the evolution and molecular basis of plant–pathogen interactions has recently been advanced by bringing together genetic and genomic studies of both plants and pathogens. Insights into the strategies used by plants to recognize pathogens may lead to novel agricultural applications.

Peter N. Dodds
John P. Rathjen
Reviews29 Jun 2010
Nature Reviews Genetics

Volume: 11, P: 539-548
Wheeling in a new era in plant immunity

Pathogen perception in plants is mediated by immune receptors that detect specific pathogen molecules. Members of one diverse receptor family that occurs in all land plants form a structurally conserved activation complex with a shared signalling mechanism.

Megan A. Outram
Peter N. Dodds
News & Views14 Oct 2022
Nature Plants

Volume: 8, P: 1142-1143
JNK/SAPK activity contributes to TRAIL-induced apoptosis

Ingrid Herr
Dagmar Wilhelm
Klaus-Michael Debatin
Research28 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 130-135
A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes

The tall wheat grass-derived stem rust resistance genes Sr26 and Sr61 are among a few ones that are effective to all current dominant races of stem rust, including Ug99. Here, the authors show that the two genes are present in a small non-recombinogenic segment but encode two unrelated NLR proteins.

Jianping Zhang
Timothy C. Hewitt
Evans S. Lagudah
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-8
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Twitter misogyny associated with Hillary Clinton increased throughout the 2016 U.S. election campaign

Morgan Weaving
Thayer Alshaabi
Cordelia Fine
ResearchOpen Access31 Mar 2023
Scientific Reports

Volume: 13, P: 1-7
Genomics accelerated isolation of a new stem rust avirulence gene–wheat resistance gene pair

New emerged variants of stem rust threaten wheat production globally. Here, mutational genomics is used to characterize a new resistance gene named Sr27 both in wheat and in triticale, and the corresponding secreted effector in the pathogen, AvrSr27.

Narayana M. Upadhyaya
Rohit Mago
Peter N. Dodds
Research22 Jul 2021
Nature Plants

Volume: 7, P: 1220-1228
Zipf’s law holds for phrases, not words

Jake Ryland Williams
Paul R. Lessard
Peter Sheridan Dodds
ResearchOpen Access11 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat

Combining fungal-resistance genes into a single cassette enables the generation of highly resistant wheat lines.

Ming Luo
Liqiong Xie
Michael Ayliffe
Research04 Jan 2021
Nature Biotechnology

Volume: 39, P: 561-566
Phenoxy herbicides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphoma

JG Smith
AJ Christophers
Research01 Mar 1992
British Journal of Cancer

Volume: 65, P: 442-448
Melanoma protective antitumor immunity activated by catalytic DNA

Hong Cai
Eun-Ae Cho
Levon M. Khachigian
Research29 May 2018
Oncogene

Volume: 37, P: 5115-5126
A recently evolved hexose transporter variant confers resistance to multiple pathogens in wheat

Evans Lagudah and colleagues report that variation in a gene encoding a hexose transporter confers resistance to multiple pathogens in wheat. They further show that the variant protein encoded by the resistance allele exerts a dominant-negative effect by heterodimerizing with functional hexose transporters, resulting in reduced glucose uptake.

John W Moore
Sybil Herrera-Foessel
Evans Lagudah
Research09 Nov 2015
Nature Genetics

Volume: 47, P: 1494-1498
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer

M L Veronese
W Sun
P J O'Dwyer
ResearchOpen Access03 May 2005
British Journal of Cancer

Volume: 92, P: 1846-1849
Forecasting the onset and course of mental illness with Twitter data

Andrew G. Reece
Andrew J. Reagan
Ellen J. Langer
ResearchOpen Access11 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
LOCALIZER: subcellular localization prediction of both plant and effector proteins in the plant cell

Jana Sperschneider
Ann-Maree Catanzariti
Jennifer M. Taylor
ResearchOpen Access16 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Melanoma pathology reporting and staging

Richard A. Scolyer
Robert V. Rawson
Victor G. Prieto
Research22 Nov 2019
Modern Pathology

Volume: 33, P: 15-24
Predicting the potential for zoonotic transmission and host associations for novel viruses

Potential host range and spillover risk for novel viruses can be predicted using a network informed by known virus-host associations.

Pranav S. Pandit
Simon J. Anthony
Christine K. Johnson
ResearchOpen Access19 Aug 2022
Communications Biology

Volume: 5, P: 1-10
The role of high-dose therapy and stem cell rescue in the management of T-cell malignant lymphomas: a BSBMT and ABMTRR study

S Feyler
H M Prince
G Cook
Research25 Jun 2007
Bone Marrow Transplantation

Volume: 40, P: 443-450
Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation

P J Shaughnessy
B J Bolwell
S Abhyankar
Research16 Nov 2009
Bone Marrow Transplantation

Volume: 45, P: 1068-1076
Author Correction: Predicting the potential for zoonotic transmission and host associations for novel viruses

Pranav S. Pandit
Simon J. Anthony
Christine K. Johnson
Amendments and CorrectionsOpen Access10 Jan 2023
Communications Biology

Volume: 6, P: 1
Dissecting causes for improved survival among patients with acute myeloid leukemia in two different eras receiving identical regimens in sequential randomized studies

Ing S. Tiong
John Reynolds
Andrew H. Wei
CorrespondenceOpen Access22 Aug 2018
Blood Cancer Journal

Volume: 8, P: 1-5

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