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Electrochemical amine regeneration offers a renewable, low-temperature pathway for CO₂ capture. Here, the authors reveal how anions regulate interfacial copper redox kinetics that control electrochemical CO₂ release using in-situ spectroscopic and computational analyses.

In targeted protein degradation, a degrader molecule brings a neosubstrate protein proximal to a hijacked E3 ligase for its ubiquitination. Here, pseudo-natural products derived from (−)-myrtanol—iDegs—are identified to inhibit and induce degradation of the immunomodulatory enzyme indoleamine-2,3-dioxygenase 1 (IDO1) by a distinct mechanism. iDegs prime apo-IDO1 ubiquitination and subsequent degradation using its native proteolytic pathway.

Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.

The Greenland shark, the longest-living vertebrate, inhabits the dim, frigid depths of the Arctic Ocean. Despite its extreme lifespan, this study finds that its vision remains intact and well-adapted for life in dim light, revealing remarkable preservation of sensory function across centuries.

This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to cytomegalovirus infection and influenza vaccination.

Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.

Wide-bandgap perovskite solar cells suffer from instability under rapid thermal cycling. Here, Sun et al. investigate the degradation mechanism, showing that temperature-induced structural strain, phase transition, and increased non-radiative defects drive the degradation processes.

T-cell therapies have huge potential but face technical limitations. Here, the authors report on a dextran-based nanoparticle platform that efficiently expands T cells, enhances CAR T-cell potency, persistence, and anti-tumour efficacy, using simpler and faster methods than current techniques.

The climate impact of aviation results largely from contrail-cirrus clouds. This study shows that most contrail-cirrus exist within natural cirrus clouds. Depending on cloud properties, their climate effects may range from additional warming to cooling.

Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units encoding deviations from prior mean and a lack of sensory prediction errors in frontal areas.

Although FZDs are promising drug targets, so far no small molecules targeting them were described. Here, the authors report the a FZD7 core-targeting small molecule negative allosteric modulators of WNT-induced signaling, confirmed by pharmacology, structure determination and MD simulations.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Early high-resolution images of two 2021 novae reveal eruptions unfolding in multiple stages with colliding outflows that produce shocks and gamma rays, reshaping our understanding of stellar explosions.

Acylhydrazones are often found in compounds across screening databases, and numerous bioactive acylhydrazones exist. This functional group can isomerize between E and Z in response to light or upon exposure to thiols. Now, E/Z isomerization is found to impact activities of bioactive acylhydrazones and should be routinely analysed.

Drug-resistant bacterial infections hinder tissue repair and regeneration. Here, authors present a lysozyme nanofibril-based hydrogel that mimics neutrophil extracellular traps, enabling pathogen elimination and promoting tissue regeneration.

Channelrhodopsins (ChRs) are algal light-gated ion channels used as optogenetic tools for manipulating neuronal activity. Here authors present a metagenomically identified family of phylogenetically distinct anion-conducting ChRs (MerMAIDs) which desensitize during continuous illumination due to accumulation of a non-conducting photointermediate.

The activation of dioxygen at metal centres, and subsequent functionalization of unactivated C‒H bonds, requires the generation of high-energy radical intermediates that often result in undesirable side reactions. Now an elusive oxygen-derived reactive iron(II)–radical intermediate is spectroscopically characterized as part of a strategy to stabilize phenoxyl radical cofactors during substrate oxidation reactions.

Here, the authors find that relative abundances of stress-sensitive gastrointestinal microbes at age 2 years predicts internalizing symptoms in middle childhood through altered emotion-related brain network connectivity.

Photochemical hazes in exoplanet atmospheres work as opacity barriers, hindering characterization of the atmospheres themselves. Here laboratory experiments quantify the haze surface energies that factor into the removal of hazes from atmospheres, which, when added to existing data on haze production, give a greater understanding of haze properties.

The effect of expanded glaciation on the relief of mountain ranges is debated. Chronometric and model data from the European Alps suggest that relief in the Rhône Valley was enhanced as a result of the increased incision of the valley following the mid-Pleistocene climate transition.

The authors present an in-depth investigation of excited state dynamics and molecular mechanism of the voltage sensing in microbial rhodopsins. Using a combination of spectroscopic investigations and molecular dynamics simulations, the study proposes the voltage-modulated deprotonation of the chromophore as the key event in the voltage sensing. Thus, molecular constraints that may further improve the fluorescence quantum yield and the voltage sensitivity are presented.

Understanding excited carrier dynamics in semiconductors is central to the continued development of optoelectronic devices. Using extreme ultraviolet transient absorption spectroscopy, Zürchet al. directly and simultaneously observe ultrafast electron and hole dynamics in germanium thin films.

The interplay between the chromatin landscape and plant domestication remains unclear. Here, the authors report the genome assembly and chromatin landscape map of amaranth and reveal the association between domestication and species-specific changes in chromatin accessibility, with a bias toward opening chromatin regions.

The facile synthesis and spectroscopic identification of previously unreported hexanitrogen C_2h-N₆ is described, representing experimentally realized neutral molecular nitrogen allotropes beyond N₂ that exhibit unexpected stability.

The use of bulky protein tags and the limited positions available for probe introduction restrict current methods for studying protein microenvironments at high spatial resolution. Here the authors genetically incorporate small environment-sensitive fluorescent amino acids to visualize real-time microenvironmental changes at specific protein substructures.

The unique structure and mechanism of chanoclavine synthase (EasC), a haem catalase that uses superoxide for substrate transformation in ergot alkaloid biosynthesis, are revealed in this study, challenging established catalase mechanisms.

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Although photodriven molecular motors—capable of converting light into unidirectional motion—hold promise for many applications, these typically require ultraviolet light. Here, the authors design and analyse a motor that can operate at high speeds (kHz) under visible light at ambient temperature.

An artificial nerve that is based on a vertical n-type organic electrochemical transistor with a gradient-intermixed bicontinuous structure can operate at high frequencies and mimic basic conditioned reflex behaviour in animals.

Alloying formamidinium into the A-site of red-emitting CsPbI₃ perovskite nanoplatelets enhances their long-term stability and production of linearly polarized light through improved superlattice formation, offering a pathway towards reliable polarized light sources.

It is generally believed that, after being generated, an excess electron in water shrinks from a strongly delocalized to a localized state in about a picosecond. Now, these early stages in the behaviour of this electron have been observed using a combination of transient THz spectroscopy and ab initio molecular dynamics simulations.

Control over the selectivity of chemical reactions and biological molecules requires an intimate understanding of how conformation impacts reactivity. It is now shown that the trans conformer of trifluoromethylhydroxycarbene preferentially rearranges through a quantum-mechanical hydrogen-tunnelling pathway, whereas its cis conformer is unreactive.

The enzymes and pathway involved in the biosynthesis of coenzyme F₄₃₀ are identified, completing our understanding of how members of the cyclic modified tetrapyrrole family are constructed.

Resorption of myocardial scar and subsequent regeneration may be influenced by the extent of irreversible pyridinoline and deoxypyridinoline collagen cross-links that develop in the scar. Hydroxylation of lysine in collagen may regulate this process.

The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase.

Control of liquid-based materials is important for developing materials based on these, but topological flexibility is limited. Here, the authors report a method for digital fabrication of slippery objects with solid-liquid composite interfaces and geometric design freedom.

Theory predicts that graphene nanoribbons with width less than 2 nm exhibit bandgaps comparable to silicon, but the fabrication is challenging. Vo et al.report a bottom–up approach to synthesize bulk quantities of these materials with a bandgap of ~1.3 eV, potentially useful for electronic devices.

Dye coating techniques for colored materials are often cost intensive or cause degradation of the material during processing. Here the authors demonstrate a fast, scalable and cost efficient plasma dye coating procedure, which allows for covalent immobilization of dye molecules on different polymer surfaces.

Current treatment options for ovarian cancer are limited to surgery and chemotherapy, but most patients experience recurrent metastatic diseases. Here, the authors develop an antigen–adjuvant combination immunotherapy for ovarian cancer by coupling tumor antigen loaded liposomes with plant virus adjuvant as a vaccine platform to prevent cancer recurrence and metastatic diseases.

Iron coordination complexes can be used to gain insight on biologically relevant iron-oxygen compounds generated in iron metalloenzymes. Here, the authors characterise a μ-1,2-hydroperoxo Fe^IIIFe^III and a μ-1,2-peroxo Fe^IVFe^III, and study their reactivity in C-H activation.

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

Few studies have investigated the structural properties of organic mixed ionic-electronic conductors in relation to the transient device characteristics. Here, Kim et al. show that backbone-dependent molecular orientation affects ion injection directionality, which determines ion mobility and transient response.