Nature Search

Seeking the ultimate challenge

Petter Brodin
Comments & Opinion03 Jul 2019
Nature Medicine

Volume: 25, P: 1026
Mapping the effects of gender-affirming sex hormone therapy

A study uses plasma proteome analysis to illuminate systemic effects of feminizing gender-affirming hormone therapy; more research like this will inform better healthcare for transgender people and could hold insights into sex-specific immune regulation.

Petter Brodin
News & Views13 Jan 2026
Nature Medicine

Volume: 32, P: 34-35
Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy

Anna James
Petter Brodin
Amendments and Corrections10 Sept 2024
Nature Reviews Immunology

Volume: 24, P: 771
Author Correction: Immune system adaptation during gender-affirming testosterone treatment

Tadepally Lakshmikanth
Camila Consiglio
Petter Brodin
Amendments and CorrectionsOpen Access24 Sept 2024
Nature

Volume: 634, P: E5
Immune system adaptation during gender-affirming testosterone treatment

Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses in cisgender individuals.

Tadepally Lakshmikanth
Camila Consiglio
Petter Brodin
ResearchOpen Access04 Sept 2024
Nature

Volume: 633, P: 155-164
Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity

Previous reports suggested systemic bile acids are associated with the onset of type 1 diabetes. Here authors identified age-dependent trajectories of bile acids in children who developed islet autoantibodies during a longitudinal study.

Santosh Lamichhane
Alex M. Dickens
Matej Orešič
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Expression of CD226 is associated to but not required for NK cell education

CD226 is an activating receptor expressed in a co-varied manner with inhibitory receptors on natural killer (NK) cells, but whether CD226 is involved in NK cell education is unclear. Here the authors show that CD226 expression is plastic depending on the MHC environment and endows educated NK cells enhanced effector functions.

Arnika K. Wagner
Nadir Kadri
Benedict J. Chambers
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-14
Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

Lili Hu
Renee M. van der Sluis
Trine H. Mogensen
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-23
Human immune system variation

This Review provides a comprehensive overview of the influences on human immune system variation. Systems immunology analyses have revealed that variations between individuals are mainly due to non-heritable influences such as age, sex, microbiota and the environment.

Petter Brodin
Mark M. Davis
Reviews05 Dec 2016
Nature Reviews Immunology

Volume: 17, P: 21-29
Platelet partnerships and lasting memories

Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.

Petter Brodin
News & Views02 Jan 2025
Nature Immunology

Volume: 26, P: 7-8
Current perspectives of natural killer cell education by MHC class I molecules

This article discusses the current models of how ligation of inhibitory receptors on NK cells by host MHC class I molecules can result in 'educated' NK cells and the recent insights into the signalling pathways that are involved. How MHC class I molecules can regulate receptor repertoire formation in NK cells is also discussed.

Petter Höglund
Petter Brodin
Reviews06 Sept 2010
Nature Reviews Immunology

Volume: 10, P: 724-734
Molecular pixelation: spatial proteomics of single cells by sequencing

Molecular Pixelation is an optics-free method that uses DNA-tagged antibodies to enable identification of the relative location of proteins on single cells.

Filip Karlsson
Tomasz Kallas
Simon Fredriksson
ResearchOpen Access08 May 2024
Nature Methods

Volume: 21, P: 1044-1052
Immunological studies in trans-individuals undergoing gender affirming hormone therapy

Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences of long-term sex-hormone supplementation on immunity in transgender individuals.

Anna James
Petter Brodin
Comments & Opinion04 Sept 2024
Nature Reviews Immunology

Volume: 24, P: 697-698
The repertoire of maternal anti-viral antibodies in human newborns

A longitudinal survey of maternal antiviral antibodies in newborns provides a blueprint for understanding infectious disease susceptibility and vaccine development, and inform vaccine scheduling in newborn children.

Christian Pou
Dieudonné Nkulikiyimfura
Petter Brodin
Research18 Mar 2019
Nature Medicine

Volume: 25, P: 591-596
Health outcomes in hospitalised and non-hospitalised individuals after COVID-19, an observational, cross-sectional study

Nygren-Bonnier et al. explore symptoms and health outcomes after COVID-19 linked to self-rated health and identify cluster profiles. Around two-thirds of individuals showed physical and mental impairments associated with low self-rated health, and four cluster profiles were identified, highlighting the need for tailored long-term interventions

Malin Nygren-Bonnier
Anna Svensson-Raskh
Elisabeth Rydwik
ResearchOpen Access04 Dec 2025
Communications Medicine

Volume: 5, P: 1-10
Systems-level patterns emerge

Our knowledge of how the immune system changes with age has benefitted from a growing appreciation of the importance of systems-level analyses in humans. We are now beginning to uncover the global patterns of immune system development and decline in the young and the elderly.

Petter Brodin
News & Views03 Jan 2019
Nature Reviews Immunology

Volume: 19, P: 87-88
Immune determinants of COVID-19 disease presentation and severity

The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.

Petter Brodin
Reviews13 Jan 2021
Nature Medicine

Volume: 27, P: 28-33
Studying severe long COVID to understand post-infectious disorders beyond COVID-19

Petter Brodin
Giorgio Casari
Jean-Laurent Casanova
Correspondence05 Apr 2022
Nature Medicine

Volume: 28, P: 879-882
Integration of molecular profiles in a longitudinal wellness profiling cohort

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, the authors sample a longitudinal wellness cohort and analyse blood molecular profiles as well as gut microbiota composition.

Abdellah Tebani
Anders Gummesson
Linn Fagerberg
ResearchOpen Access08 Sept 2020
Nature Communications

Volume: 11, P: 1-14
The maternal gut microbiome in pregnancy: implications for the developing immune system

This Review discusses how the maternal gut microbiome in pregnancy influences the developing immune system and proposes avenues for future research.

Omry Koren
Liza Konnikova
Maria Carmen Collado
Reviews14 Dec 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 35-45
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Diversity in immunogenomics: the value and the challenge

Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understanding of human immunology.

Kerui Peng
Yana Safonova
Serghei Mangul
Comments & Opinion17 May 2021
Nature Methods

Volume: 18, P: 588-591
Smoking changes adaptive immunity with persistent effects

A survey of 136 factors that may influence cytokine secretion identify smoking, cytomegalovirus latent infection and body mass index as influential factors, with varying effects on innate and adaptive immunity.

Violaine Saint-André
Bruno Charbit
Christophe Zimmer
ResearchOpen Access14 Feb 2024
Nature

Volume: 626, P: 827-835
Selective transfer of maternal antibodies in preterm and fullterm children

Sepideh Dolatshahi
Audrey L. Butler
Galit Alter
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-16
Investigation of the sero-epidemiology of vaccine preventable diseases and common viral infections in French populations

Bloch et al., develop a high-throughput multiplex serological assay using bead-based Luminex technology to measure antibodies to a broad panel of vaccine-preventable diseases and common viral infections. They find a high level of population-level immunity to respiratory viruses and vaccine-preventable diseases, but with some notable immunity gaps in young children.

Emma Bloch
Gaëlle Baudemont
Michael White
ResearchOpen Access13 Nov 2025
Communications Medicine

Volume: 5, P: 1-11
The immune factors driving DNA methylation variation in human blood

Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.

Jacob Bergstedt
Sadoune Ait Kaci Azzou
Lluis Quintana-Murci
ResearchOpen Access06 Oct 2022
Nature Communications

Volume: 13, P: 1-20
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals

Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions.

Christophe Boetto
Violeta Basten Romero
Hugues Aschard
ResearchOpen Access06 Nov 2025
Communications Biology

Volume: 8, P: 1-11
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells

Thuy Thanh Luu
Sridharan Ganesan
Nadir Kadri
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Evangelos Andreakos
Laurent Abel
András N. Spaan
Amendments and Corrections24 Nov 2021
Nature Immunology

Volume: 23, P: 341
Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination

Ahmet Yalcinkaya
Marco Cavalli
Nils Landegren
ResearchOpen Access18 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines

Ahmet Yalcinkaya
Marco Cavalli
Nils Landegren
ResearchOpen Access22 Feb 2024
npj Vaccines

Volume: 9, P: 1-6
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Jamie A. Sugrue
Megan Smith
Cliona O’Farrelly
ResearchOpen Access15 Apr 2022
Genes & Immunity

Volume: 23, P: 93-98
High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood

Stefan Petkov
Yonas Bekele
Francesca Chiodi
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination

Marco Cavalli
Niclas Eriksson
Mia Wadelius
ResearchOpen Access08 May 2025
npj Vaccines

Volume: 10, P: 1-7
Human genetic and immunological determinants of critical COVID-19 pneumonia

The COVID Human Genetic Effort examines the molecular, cellular and immunological determinants of the various SARS-CoV-2-related disease manifestations by searching for causal errors of immunity.

Qian Zhang
Paul Bastard
Jean-Laurent Casanova
Reviews28 Jan 2022
Nature

Volume: 603, P: 587-598
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

In this Perspective, Spaan and colleagues propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.

Evangelos Andreakos
Laurent Abel
András N. Spaan
Reviews18 Oct 2021
Nature Immunology

Volume: 23, P: 159-164
Antisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants

Anna Gustafsson
Ewa Johansson
Kajsa Bohlin
ResearchOpen Access24 Nov 2023
Pediatric Research

Volume: 95, P: 762-769
Dramatic changes in blood protein levels during the first week of life in extremely preterm infants

Wen Zhong
Hanna Danielsson
Mathias Uhlén
Research24 Apr 2020
Pediatric Research

Volume: 89, P: 604-612

Search

Filter By:

Search

Quick links