Nature Search

AI-powered segmentation and prognosis with missing MRI in pediatric brain tumors

Dimosthenis Chrysochoou
Deep B. Gandhi
Anahita Fathi Kazerooni
ResearchOpen Access13 Jan 2026
npj Precision Oncology

P: 1-9
Climate change impacts on ocean light in Arctic ecosystems

Climate change will decrease Arctic Sea ice and increase light, but effects on polar ecosystems remain unclear. Here, the authors predict that warming waters and prey loss will threaten cold-water fish species and severely reduce their habitat by 2060.

Trond Kristiansen
Øystein Varpe
Phillip J. Wallhead
ResearchOpen Access06 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli

The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

Santiago E. Caño Muñiz
Stephen Trigg
R. Andres Floto
ResearchOpen Access24 Nov 2025
Nature Microbiology

Volume: 10, P: 3202-3214
Space radiation measurements during the Artemis I lunar mission

Measurements from the heavily shielded Orion spacecraft during the uncrewed Artemis I mission show dose-rate reductions due to shielding and orientation for Van Allen belt crossings and quantify the interplanetary cosmic-ray radiation in a human-rated spacecraft.

Stuart P. George
Ramona Gaza
Thomas Berger
ResearchOpen Access18 Sept 2024
Nature

Volume: 634, P: 48-52
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors

The role of rare pathogenic/likely pathogenic (P/LP) germline variants in pediatric central nervous system (CNS) tumour development remains poorly understood. Here, the authors investigate the prevalence and clinical significance of germline P/LP variants in cancer predisposition genes across 830 CNS tumour patients.

Ryan J. Corbett
Rebecca S. Kaufman
Sharon J. Diskin
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Robust identification of perturbed cell types in single-cell RNA-seq data

Single-cell RNA-seq experiments often aim to identify cell types that have significant transcriptional differences between two or more biological conditions. Here, authors introduce scDist, a statistical approach to identify perturbed cell types that controls for common confounders in these data.

Phillip B. Nicol
Danielle Paulson
Avinash D. Sahu
ResearchOpen Access01 Sept 2024
Nature Communications

Volume: 15, P: 1-14
A machine learning-based evidence map of ocean-related options for climate change mitigation and adaptation

Devi Veytia
Gaël Mariani
Jean-Pierre Gattuso
ResearchOpen Access19 Nov 2025
npj Ocean Sustainability

Volume: 4, P: 1-13
Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Here the authors deliver aerosolized human monoclonal antibodies to SARS-CoV-2-infected rhesus macaques and show that the treatment significantly reduces viral RNA and infectious virus in the respiratory tracts, limits lung pathology, and decreases inflammatory cytokines.

Daniel N. Streblow
Alec J. Hirsch
Nancy L. Haigwood
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

Phillip J. Robinson
Jean-Marie Sontag
Thomas C. Südhof
Research09 Sept 1993
Nature

Volume: 365, P: 163-166
Antarctic ice shelf disintegration triggered by sea ice loss and ocean swell

Less sea ice allowed ocean swells to flex weakened ice shelves in Antarctica, contributing to their collapse.

Robert A. Massom
Theodore A. Scambos
Sharon E. Stammerjohn
Research13 Jun 2018
Nature

Volume: 558, P: 383-389
Genomic insights into the secondary aquatic transition of penguins

This study examines the tempo and drivers of penguin diversification by combining genomes from all extant and recently extinct penguin lineages, stratigraphic data from fossil penguins and morphological and biogeographic data from all extant and extinct species. Together, these datasets provide new insights into the genetic basis and evolution of adaptations in penguins.

Theresa L. Cole
Chengran Zhou
Guojie Zhang
ResearchOpen Access19 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung histopathology scoring system.

Francisco J. Salguero
Andrew D. White
Miles W. Carroll
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma

Understanding the molecular and pathological features of paediatric low-grade glioma (pLGG) is crucial to develop targeted therapies. Here, the authors perform a radiogenomic analysis of pLGGs combining treatment-naïve multiparametric MRI and RNA sequencing, enabling prognostication based on immune profiles as well as prediction of treatment response.

Anahita Fathi Kazerooni
Adam Kraya
Ali Nabavizadeh
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Cdk5 is essential for synaptic vesicle endocytosis

Timothy C. Tan
Valentina A. Valova
Phillip J. Robinson
Research13 Jul 2003
Nature Cell Biology

Volume: 5, P: 701-710
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

Victor Anggono
Karen J Smillie
Phillip J Robinson
Research30 Apr 2006
Nature Neuroscience

Volume: 9, P: 752-760
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations

Vein of Galen malformations (VOGMs) are severe congenital brain arteriovenous malformations. Here the authors work to elucidate the pathogenesis of VOGMs by performing an integrated analysis of 310 VOGM proband family exomes and 336,326 human cerebrovasculature single-cell transcriptomes to identify mutations of key signaling regulators.

Shujuan Zhao
Kedous Y. Mekbib
Kristopher T. Kahle
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-23
Gene-engineered T cells for cancer therapy

Adoptive T cell therapy using engineered T cells to improve antitumour responses is showing promise for the treatment of haematological malignancies in particular. This Review discusses the strategies to engineer T cells and the progress that has been made with using gene-modified T cells to treat cancer patients.

Michael H. Kershaw
Jennifer A. Westwood
Phillip K. Darcy
Reviews24 Jul 2013
Nature Reviews Cancer

Volume: 13, P: 525-541
Spatially resolved Hall effect measurement in a single semiconductor nanowire

Hall effect measurement set-up on a single core–shell semiconductor nanowire enables spatially resolved determination of carrier concentration and mobility in the nanowire shell.

Kristian Storm
Filip Halvardsson
Lars Samuelson
Research28 Oct 2012
Nature Nanotechnology

Volume: 7, P: 718-722
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid leukaemia.

Malgorzata Gozdecka
Monika Dudek
George S. Vassiliou
ResearchOpen Access16 Apr 2025
Nature

Volume: 642, P: 431-441
Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation

Marjorie Labrecque
Elsa Brunet-Ratnasingham
Martine Tetreault
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-16
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Keith Ligon, Adam Resnick, Rameen Beroukhim and colleagues identify MYB-QKI fusions in angiocentric gliomas and show that these rearrangements promote tumorigenesis through activation of MYB by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of QKI.

Pratiti Bandopadhayay
Lori A Ramkissoon
Adam C Resnick
Research01 Feb 2016
Nature Genetics

Volume: 48, P: 273-282
Curbing the major and growing threats from invasive alien species is urgent and achievable

This Perspective highlights the global consensus on the urgency and growing threat of invasive alien species, and management needs, as found by the 2023 report on invasive alien species conducted by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES).

Helen E. Roy
Aníbal Pauchard
Sílvia R. Ziller
Reviews03 Jun 2024
Nature Ecology & Evolution

Volume: 8, P: 1216-1223
Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

Inflammation is a known driver of diabetes and obesity-associated kidney disease. This Review describes the role of endogenous lipid mediators — specialized pro-resolving lipid mediators and branched fatty acid esters of hydroxy fatty acids — in the resolution of inflammation and explores how insights into their function could identify new targets for therapeutic intervention.

Eoin Brennan
Phillip Kantharidis
Catherine Godson
Reviews19 Jul 2021
Nature Reviews Nephrology

Volume: 17, P: 725-739
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

Sandro Santagata, Gad Getz and colleagues report the discovery of a recurrent mutation in the oncogene BRAF in papillary craniopharyngiomas that does not occur in the histologically related adamantinomatous form. Their results have the potential to aid in diagnosis and treatment of these intracranial tumors.

Priscilla K Brastianos
Amaro Taylor-Weiner
Sandro Santagata
Research12 Jan 2014
Nature Genetics

Volume: 46, P: 161-165
High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Sayera Dhaubhadel
Kumkum Ganguly
Benjamin H. McMahon
ResearchOpen Access20 Jan 2024
Scientific Reports

Volume: 14, P: 1-19
Technical note: Traumatic atlanto-occipital dislocation and severe subaxial cervical distraction injury in an infant

Alexander M. Tucker
Peter J. Madsen
Phillip B. Storm
Research04 Jan 2024
Spinal Cord Series and Cases

Volume: 10, P: 1-3
Viral vector platforms within the gene therapy landscape

Jote T. Bulcha
Yi Wang
Guangping Gao
ReviewsOpen Access08 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-24
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

John G Shelton
Linda S Steelman
James A McCubrey
Research25 Apr 2003
Oncogene

Volume: 22, P: 2478-2492
Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c

T M Hansen
D J Smith
P Nagley
Research21 Oct 2005
Cell Death & Differentiation

Volume: 13, P: 1181-1190
Radiomics for characterization of the glioma immune microenvironment

Nastaran Khalili
Anahita Fathi Kazerooni
Ali Nabavizadeh
ReviewsOpen Access19 Jun 2023
npj Precision Oncology

Volume: 7, P: 1-14

Search

AI-powered segmentation and prognosis with missing MRI in pediatric brain tumors

Climate change impacts on ocean light in Arctic ecosystems

Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli

Space radiation measurements during the Artemis I lunar mission

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors

Robust identification of perturbed cell types in single-cell RNA-seq data

A machine learning-based evidence map of ocean-related options for climate change mitigation and adaptation

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

Antarctic ice shelf disintegration triggered by sea ice loss and ocean swell

Genomic insights into the secondary aquatic transition of penguins

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma

Cdk5 is essential for synaptic vesicle endocytosis

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations

Gene-engineered T cells for cancer therapy

Spatially resolved Hall effect measurement in a single semiconductor nanowire

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Curbing the major and growing threats from invasive alien species is urgent and achievable

Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Technical note: Traumatic atlanto-occipital dislocation and severe subaxial cervical distraction injury in an infant

Viral vector platforms within the gene therapy landscape

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c

Radiomics for characterization of the glioma immune microenvironment

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