The Nipah virus (NiV) polymerase complex is an ideal target for drug development. Here, the authors determine the cryo-EM structures of NiV L-P polymerase complexes and reveal how NiV is resistant to the allosteric L-targeting inhibitor GHP-88309. Furthermore, the authors demonstrate that suramin could inhibit NiV L-P complex at both enzymatic and cellular levels.
- Qi Peng
- Yingying Dong
- Yi Shi
