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Showing 1–3 of 3 results
Advanced filters: Author: Qingchao Fan Clear advanced filters

  • ADGRL4 is a cancer-implicated adhesion GPCR whose ability to couple to G proteins had been unclear. Here, authors show that ADGRL4 weakly engages Gq and determine its 3.1 Å active-state structure, revealing its mechanism of activation.

    • Qingchao Chen
    • Anastasiia Gusach
    • David M. Favara
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

    • Ruixin Ge
    • Miao Chen
    • Songbo Xie
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15