Nature Search

Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function

Fatty liver disease may harm the brain by starving it of a protective fuel. This study shows that restoring this fuel, BHB, can rescue memory and brain health, revealing a direct liver-brain link and a promising treatment target.

Lijuan Nie
Jing Sun
Xiqiao Zhou
ResearchOpen Access10 Jan 2026
Communications Biology

P: 1-13
SARS-CoV-2 nsp14 induces the m⁷G methylation and the sequestration of host RNAs in stress granules

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

Xiaoxiao Li
Weiyi Huang
Xiaoxue Peng
ResearchOpen Access30 Dec 2025
Communications Biology

P: 1-16
High-energy and fast-charging lithium metal batteries enabled by tuning Li⁺-solvation via electron-withdrawing and lithiophobicity functionality

The electrochemical stability window and Li⁺ transport limit the energy-dense and fast-charging capability of lithium metal batteries. Here, authors report a trifluoride ether-based electrolyte to stabilize energy-dense lithium metal batteries under high current rates.

Guangzhao Zhang
Tong Zhang
Yonghong Deng
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-12
The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription

Cytosolic CHMP5 is known for its primary function in membrane remodelling. Here the authors report that nuclear CHMP5 promotes T cell acute lymphoblastic leukemia initiation and maintenance in part through regulating epigenetic and transcriptional events.

Katharine Umphred-Wilson
Shashikala Ratnayake
Stanley Adoro
ResearchOpen Access03 May 2025
Nature Communications

Volume: 16, P: 1-19
Microwave-assisted Ring-Opening Polymerization of ɛ-Caprolactone in Presence of Hydrogen Phosphonates

Ye Tan
Shaojun Cai
Lijian Liu
Research12 Aug 2009
Polymer Journal

Volume: 41, P: 849-854
Ambient temperature and emergency department visits for mental disorder before and during the COVID-19 pandemic

Authors analyze the associations of emergency admissions related to mental health disorders with short-term temperature changes before and during the COVID-19 pandemic, providing evidence for increased risks for depression-related visits associated with elevated temperatures during the pandemic.

Keyu Wu
Junwei Yan
Jian Cheng
Research05 Feb 2024
Nature Mental Health

Volume: 2, P: 278-286
Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM

CryoEM sample preparation for low abundance or preferentially oriented particles remains challenging. Jianbing Ma et al. develop the mspSA affinity-grid method that enriches particles on EM grids and reduces air-water interface exposure, demonstrating usefulness for several difficult samples.

Jianbing Ma
Gangshun Yi
Peijun Zhang
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Real-time segmentation method of billet infrared image based on multi-scale feature fusion

Lixin Zhang
Qingrong Nan
Zhengguang Xu
ResearchOpen Access27 Apr 2022
Scientific Reports

Volume: 12, P: 1-7
Elf1 promotes transcription-coupled repair in yeast by using its C-terminal domain to bind TFIIH

The elongation factor Elf1 functions in transcription coupled-nucleotide excision repair (TC-NER), but the mechanism by which yeast Elf1 promotes repair was unclear. Here, the authors show that Elf1 promotes TC-NER by binding TFIIH through a conserved sequence motif in its C-terminal domain.

Kathiresan Selvam
Jun Xu
John J. Wyrick
ResearchOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease

Transcription-blocking DNA lesions lead to transcription stress that is associated with neurodegeneration and accelerated ageing. Recent structural and other findings have clarified how different obstructing lesions are recognized and removed and shed new light on the causes of various pathologies of repair deficiencies.

Marjolein van Sluis
Camila Gonzalo-Hansen
Jurgen A. Marteijn
Reviews18 Nov 2025
Nature Reviews Molecular Cell Biology

P: 1-18
X-ray crystallography reveals insulin lisargine structure and mechanisms of glucose regulation

Zhu Zhu
Zhiming Zheng
Peng Wang
ResearchOpen Access25 Sept 2025
Scientific Reports

Volume: 15, P: 1-15
Steady-state equation of water vapor sorption for CaCl₂-based chemical sorbents and its application

Haiquan Zhang
Yanping Yuan
Liangliang Sun
ResearchOpen Access29 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Recommendations are given on optimal read coverage and selection of calling algorithm to maximize the reproducibility of cancer mutation detection in whole-genome or whole-exome sequencing.

Wenming Xiao
Luyao Ren
Leming Shi
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1141-1150
Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration

Zihan Li
Chuwei Zhang
Yi Zhang
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Li Tai Fang
Bin Zhu
Yuanting Zheng
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1151-1160
Function of MYB8 in larch under PEG simulated drought stress

Qingrong Zhao
Huanhuan Xiong
Lei Zhang
ResearchOpen Access17 May 2024
Scientific Reports

Volume: 14, P: 1-17
Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia

Dandan Sun
Huiling Guo
Fei Wang
ResearchOpen Access27 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-9
Design and bioactivity evaluation of a novel autotaxin inhibitor with anti-hepatic fibrosis effects

Yuzheng Liu
Dan Luo
Weijie Peng
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns

Zhihan Zhu
Xinghua Zhu
Kesu Hu
ResearchOpen Access22 Jan 2025
Scientific Reports

Volume: 15, P: 1-17
Analysis of oxidase activity and transcriptomic changes related to cutting propagation of hybrid larch

Ruofan Qin
Qingrong Zhao
Hanguo Zhang
ResearchOpen Access24 Jan 2023
Scientific Reports

Volume: 13, P: 1-12
Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia

Huaning Wang
Ling-Li Zeng
Dewen Hu
ResearchOpen Access30 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Building adjustment capacity to cope with running water in cultured grass carp through flow stimulation conditions

Qingrong Xie
Li Wang
Ziwei Chen
ResearchOpen Access14 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
Cannabinoid receptor subtype 2 (CB₂R) agonist, GW405833 reduces agonist-induced Ca²⁺ oscillations in mouse pancreatic acinar cells

Zebing Huang
Haiyan Wang
Jie Wu
ResearchOpen Access19 Jul 2016
Scientific Reports

Volume: 6, P: 1-14
Genetic transformation of LoHDZ2 and analysis of its function to enhance stress resistance in Larix olgensis

Peiqi An
Ruofan Qin
Lei Zhang
ResearchOpen Access27 Jul 2022
Scientific Reports

Volume: 12, P: 1-15
Genetic transformation and growth index determination of the Larix olgensis LoHDZ2 transcription factor gene in tobacco

Peiqi An
Chen Wang
Hanguo Zhang
ResearchOpen Access20 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Yinghao Niu
Qingrong Nie
Dongmei Song
ResearchOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1-13
Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion

Tongtian Zhuang
Xiuli Yi
Chunying Li
ResearchOpen Access12 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-14
Methane and Nitrous Oxide Flux after Biochar Application in Subtropical Acidic Paddy Soils under Tobacco-Rice Rotation

Yibin Huang
Chengji Wang
Tieying Song
ResearchOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
The effects of manganese oxide octahedral molecular sieve chitosan microspheres on sludge bacterial community structures during sewage biological treatment

Fei Pan
Wen Liu
Dongsheng Xia
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-11

Search

Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function

SARS-CoV-2 nsp14 induces the m⁷G methylation and the sequestration of host RNAs in stress granules

High-energy and fast-charging lithium metal batteries enabled by tuning Li⁺-solvation via electron-withdrawing and lithiophobicity functionality

The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription

Microwave-assisted Ring-Opening Polymerization of ɛ-Caprolactone in Presence of Hydrogen Phosphonates

Ambient temperature and emergency department visits for mental disorder before and during the COVID-19 pandemic

Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM

Real-time segmentation method of billet infrared image based on multi-scale feature fusion

Elf1 promotes transcription-coupled repair in yeast by using its C-terminal domain to bind TFIIH

Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease

X-ray crystallography reveals insulin lisargine structure and mechanisms of glucose regulation

Steady-state equation of water vapor sorption for CaCl₂-based chemical sorbents and its application

Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Chitooligosaccharides promote diabetic wound healing by mediating fibroblast proliferation and migration

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Function of MYB8 in larch under PEG simulated drought stress

Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia

Design and bioactivity evaluation of a novel autotaxin inhibitor with anti-hepatic fibrosis effects

Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns

Analysis of oxidase activity and transcriptomic changes related to cutting propagation of hybrid larch

Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia

Building adjustment capacity to cope with running water in cultured grass carp through flow stimulation conditions

Cannabinoid receptor subtype 2 (CB₂R) agonist, GW405833 reduces agonist-induced Ca²⁺ oscillations in mouse pancreatic acinar cells

Genetic transformation of LoHDZ2 and analysis of its function to enhance stress resistance in Larix olgensis

Genetic transformation and growth index determination of the Larix olgensis LoHDZ2 transcription factor gene in tobacco

Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Intracellular virus sensor MDA5 exacerbates vitiligo by inducing the secretion of chemokines in keratinocytes under virus invasion

Methane and Nitrous Oxide Flux after Biochar Application in Subtropical Acidic Paddy Soils under Tobacco-Rice Rotation

The effects of manganese oxide octahedral molecular sieve chitosan microspheres on sludge bacterial community structures during sewage biological treatment

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