Nature Search

Lifespan normative modeling of brain microstructure

The study presents the largest to date lifespan model of brain white matter using diffusion MRI, enabling detection of individual abnormalities and revealing distinct patterns in Alzheimer’s dementia, cognitive impairment, and a high-risk genetic deletion.

Julio E. Villalón-Reina
Alyssa H. Zhu
Paul M. Thompson
ResearchOpen Access27 May 2026
Nature Communications

Volume: 17, P: 1-18
Evolutionary characterization of lung cancer metastasis

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Sonya Hessey
Abigail Bunkum
Mariam Jamal-Hanjani
ResearchOpen Access29 Apr 2026
Nature

Volume: 653, P: 911-922
Host control of persistent Epstein–Barr virus infection

Using blood-based genome sequence data, non-genetic and genetic factors associated with control of Epstein–Barr virus during persistent infection are reported.

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
ResearchOpen Access19 Feb 2026
Nature

Volume: 653, P: 444-454
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment

DOPA decarboxylase (DDC) in cerebrospinal fluid has great diagnostic potential for Lewy body disorders. Here, the authors report limited diagnostic potential of plasma DDC and a strong association with dopaminergic treatment.

Katharina Bolsewig
Eline A. J. Willemse
Marta Del Campo Milán
ResearchOpen Access29 Jan 2025
Nature Communications

Volume: 16, P: 1-9
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy

The study identifies novel genetic variants linked to core cerebrospinal fluid Alzheimer’s Disease biomarkers using a genome-wide analysis, showing how endophenotypes can identify genes and disease mechanisms not captured by case-control studies.

Jigyasha Timsina
Chenyang Jiang
Carlos Cruchaga
ResearchOpen Access21 Apr 2026
Nature Communications

P: 1-24
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Somatic evolution following cancer treatment in normal tissue

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Oriol Pich
Sophia Ward
Nicholas McGranahan
ResearchOpen Access10 Dec 2025
Nature

Volume: 653, P: 900-910
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

Leukemic stem cells (LSCs) in chronic myeloid leukemia are resistant to imatinib and therefore are a cause of relapse. The authors show that IRAK1/4-NF-κB-PD-L1 signaling is critical to mediate imatinib resistance in LSCs and that combining imatinib with blocking this signalling pathway can eliminate LSCs.

Yosuke Tanaka
Reina Takeda
Toshio Kitamura
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity

Somatic mutations in ASXL1 lead to clonal hematopoiesis, and Sato et al. elucidate the molecular mechanisms by which mutated ASXL1 in hematopoietic cells drives atherosclerosis in mice.

Naru Sato
Susumu Goyama
Toshio Kitamura
Research09 Dec 2024
Nature Cardiovascular Research

Volume: 3, P: 1568-1583
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’

Tomoya Isobe
Masatoshi Takagi
Junko Takita
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Joint neutrino oscillation analysis from the T2K and NOvA experiments

The joint analysis of datasets from NOvA and T2K, the two currently operating long-baseline neutrino oscillation experiments, provides new constraints related to neutrino masses and fundamental symmetries.

S. Abubakar
M. A. Acero
S. Zsoldos
ResearchOpen Access22 Oct 2025
Nature

Volume: 646, P: 818-824
Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer

Yoshimi Noda
Takayuki Shiroyama
Atsushi Kumanogoh
ResearchOpen Access25 May 2022
Scientific Reports

Volume: 12, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC proliferation.

Takeshi Fujino
Susumu Goyama
Toshio Kitamura
ResearchOpen Access23 Mar 2021
Nature Communications

Volume: 12, P: 1-20
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

ASXL1 gene is often mutated in myeloid malignancies. Here, the authors show that mutant ASXL1 and BAP1 are in a positive feedback loop such that BAP1 induces monoubiquitination of mutant ASXL1, which in turn enhances BAP1 activity to potentiate myeloid transformation via HOXA clusters and IRF8.

Shuhei Asada
Susumu Goyama
Toshio Kitamura
ResearchOpen Access16 Jul 2018
Nature Communications

Volume: 9, P: 1-18
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

The role of the repressors Bach1 and Bach2 in early B cell development is unclear. Igarashi and colleagues have now found these Bach factors directly repress various myeloid genes in common lymphoid progenitors to restrict a B cell lineage fate.

Ari Itoh-Nakadai
Reina Hikota
Kazuhiko Igarashi
Research26 Oct 2014
Nature Immunology

Volume: 15, P: 1171-1180
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Significance of noninvasive prenatal testing using massively parallel sequencing in women with twin or vanishing twin pregnancies

Eri Takeda
Nobuhiro Suzumori
Akihiko Sekizawa
Research28 Mar 2025
Journal of Human Genetics

Volume: 70, P: 297-305
Data-driven characterization of distinct cognitive subtypes in Parkinson’s disease dementia

Miguel A. Labrador-Espinosa
Jesús Silva-Rodríguez
Michel J. Grothe
ResearchOpen Access09 May 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
A scoring system for AML patients aged 70 years or older, eligible for intensive chemotherapy: a study based on a large European data set using the DATAML, SAL, and PETHEMA registries

Emilie Bérard
Christoph Röllig
Christian Récher
ResearchOpen Access11 Jul 2022
Blood Cancer Journal

Volume: 12, P: 1-8
Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries

Christian Récher
Christoph Röllig
Pau Montesinos
ResearchOpen Access13 Nov 2021
Leukemia

Volume: 36, P: 913-922
Genetic association between CD96 locus and immunogenicity to anti-TNF therapy in Crohn’s disease

Adrià Aterido
Núria Palau
Antonio Julià
Research02 May 2019
The Pharmacogenomics Journal

Volume: 19, P: 547-555
Identification of a new gibberellin receptor agonist, diphegaractin, by a cell-free chemical screening system

A drug screening system identifies a gibberellin receptor agonist, diphegaractin, found to exert gibberellin-like activity in the growth and maturation of grapes, lettuce, Arabidopsis, and citrus fruit.

Akira Nozawa
Ryoko Miyazaki
Tatsuya Sawasaki
ResearchOpen Access09 May 2023
Communications Biology

Volume: 6, P: 1-11
A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease

Conor Owens-Walton
Talia M. Nir
Ysbrand van der Werf
ResearchOpen Access11 Aug 2024
npj Parkinson's Disease

Volume: 10, P: 1-12
Transfusion independence after lenalidomide discontinuation in patients with del(5q) myelodysplastic neoplasm: a HARMONY Alliance study

Elena Crisà
Elvira Mora
Valeria Santini
Research05 Aug 2024
Leukemia

Volume: 38, P: 2259-2265
Cortical microstructural associations with CSF amyloid and pTau

Talia M. Nir
Julio E. Villalón-Reina
Neda Jahanshad
ResearchOpen Access13 Dec 2023
Molecular Psychiatry

Volume: 29, P: 257-268
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI

Alyssa H. Zhu
Talia M. Nir
Neda Jahanshad
ResearchOpen Access06 May 2025
Scientific Data

Volume: 12, P: 1-18
Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells

Satoshi Hashimoto
Takato Sugiyama
Toshifumi Inada
ResearchOpen Access25 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

Julio E. Villalón-Reina
Kenia Martínez
Carrie E. Bearden
ResearchOpen Access29 Jul 2019
Molecular Psychiatry

Volume: 25, P: 2818-2831
A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC)

Marc Miravitlles
Juan José Soler-Cataluña
Joan B Soriano
Reviews25 Feb 2013
Primary Care Respiratory Journal

Volume: 22, P: 117-121
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis

David Laguna-Muñoz
Ana Jiménez-Peinado
Fernando Sarramea
Reviews14 Nov 2024
Molecular Psychiatry

Volume: 30, P: 777-785

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