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Researchers demonstrate quantum teleportation of six general states using an entangled-light-emitting diode consisting of an InAs quantum dot. The emission wavelength of quantum dots is readily tunable using electric fields. The average teleportation fidelity of 0.704±0.016 exceeds the limit possible with classical light, proving the quantum nature of the teleportation.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Genome-wide analysis in individuals of African ancestry identifies a nonsense variant in CD36 associated with increased risk of dilated cardiomyopathy (DCM), partly accounting for the higher incidence of DCM in African-ancestry populations.

Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.

Quantum teleportation enables the transfer of information between different systems, and will be important for building quantum computing networks. Here, the authors show teleportation of photons between two different sources with greatly differing bandwidths, with an average fidelity of 0.77.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Excitations of the fractional quantum Hall states are of great interest because they obey anyonic statistics, but electronic interferometers give contrasting results about their quantum coherence. Here the authors use novel two-particle time-domain interferometry to show that quantum coherence is indeed preserved.

The synthesis of interlocking molecular [n]catenanes of organic polyhedra (n = 2–3) and rings (n = 2–130) is established; however, the analogous chemistry of infinite 3D structures remains undeveloped. Now, reticular chemistry enables the synthesis of crystalline [∞]catenane covalent organic frameworks constructed from interlocking organic polyhedra.

The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with distinct fold topologies.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Truly remote, independent InGaAs quantum dots are tuned to the same energy using large applied electric fields of up to −500 kV cm⁻¹. This allows for two-photon interference of their emission under coincidence gating, and opens up the possibility of transferring quantum information between remote solid-state sources.

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Quantum communication networks would greatly benefit from the possibility to have solid-state emitters being directly interfaced with telecom fibers, without the need for wavelength conversion. Here, the authors demonstrate coherent control of an InAs/InP quantum dot, as well as entanglement between its electron spin and the frequency of a telecom photon.

The electrostatic interactions in aqueous ionic media are screened by mobile charge carriers, limiting device design and operation speed. Here the built-in electric field is leveraged to dope ions into vanadium dioxide, triggering a surface insulator-to-metal transition, further enabling high-speed in-memory sensing in aqueous solutions.

Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.

Electron-spin to photon-polarisation conversion is a promising technology for achieving free-space or fibre coupled quantum transfer. Here, the authors demonstrate acoustically-driven single photons from single electrons, without the need for self-assembled quantum dots, using a SAW-driven lateral n-i-p junction.

Developing quantum networks would require reliable sources of coherent quantum light at telecom wavelengths. Here, the authors employ elastic scattering of excitation laser photons on InAs/InP quantum dots to demonstrate the emission of telecom photons with coherence times longer than the Fourier limit.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Trans-ancestry genome-wide analyses identify multiple loci associated with ascending aortic diameter. A polygenic score constructed from these loci predicted prevalent risk of thoracic aortic aneurysm in independent populations.

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

Uygun et al. show that deletion of GABA_A receptors from the thalamic reticular nucleus using CRISPR gene editing in mice boosts the delta waves, indicating a role for GABA_A receptors on thalamic reticular nucleus neurons in NREM sleep delta oscillations.

Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

Quantum cascade lasers are compact sources, but simultaneously achieving cw operation, low divergence and single-mode emission has proven difficult. Here, Biasco et al. use a combination of distributed feedback and outcoupling via hole arrays, improving the performance of such a terahertz laser.

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

When two identical photons hit a half-silvered mirror, quantum mechanics requires that both pass through or both be reflected in the same direction. Previously, this effect had only been demonstrated with photons from similar light sources. It has now been repeated with photons generated by two completely different physical processes.

The nonlinear optical response of a single quantum dot can be used to separate the one- and two-photon components of a weak laser beam.

Genome-wide analyses identify hundreds of loci associated with kidney function. Integrated analyses of expression, methylation and single-cell open chromatin and expression data derived from human kidney samples prioritize genes and mechanisms underlying renal disease.