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Showing 1–18 of 18 results
Advanced filters: Author: Rui Benedito Clear advanced filters

  • The vascular stem cell niche regulates the proliferation and differentiation of neural stem cells (NSCs) in the adult subventricular zone. Here the authors identify EGFL7 as a neurovascular regulator of NSCsin vivo; EGFL7-knockout mice show reduced neurogenesis, and exhibit impaired olfactory perception and behaviour.

    • Frank Bicker
    • Verica Vasic
    • Mirko H. H. Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • DLL4–Notch signalling suppresses endothelial sprouting and angiogenic growth through crosstalk with the vascular endothelial growth factor (VEGF) pathway; VEGF receptor 2 has been thought to have a crucial role in this crosstalk, but now VEGF receptor 3 is shown to be the more important modulator.

    • Rui Benedito
    • Susana F. Rocha
    • Ralf H. Adams
    Research
    Nature
    Volume: 484, P: 110-114

  • Bernier-Latmani et al. report a mechanism for maintaining colon cancer-associated vasculature, in which colon endothelial apelin signaling promotes migration of distant venous endothelial cells toward the tumor progenitor cell niche to sustain VEGFA-independent vascular expansion and a normoxic microenvironment.

    • Jeremiah Bernier-Latmani
    • Christophe Cisarovsky
    • Tatiana V. Petrova
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 476-490

  • Fernández-Chacón et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.

    • Macarena Fernández-Chacón
    • Severin Mühleder
    • Rui Benedito
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 530-549

  • Arterial development relies on the timely and MYC-dependent suppression of endothelial metabolism and the cell cycle in pre-arterial endothelial cells through Notch signalling.

    • Wen Luo
    • Irene Garcia-Gonzalez
    • Rui Benedito
    Research
    Nature
    Volume: 589, P: 437-441

  • Here the authors reveal how an incoherent feedforward C/EBPα–Notch circuit times lung cell fate, guiding alveolar development, repair after injury, and shifts between protective and reparative states.

    • Amitoj S. Sawhney
    • Brian J. Deskin
    • Douglas G. Brownfield
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high mitogenic stimuli instead arrest angiogenesis due to a bell-shaped dose-response to VEGF and MAPK activity that is counteracted by Notch and p21.

    • Samuel Pontes-Quero
    • Macarena Fernández-Chacón
    • Rui Benedito
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre-dependent reporter and gene function analysis.

    • Macarena Fernández-Chacón
    • Verónica Casquero-García
    • Rui Benedito
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

    • Hans Schoofs
    • Nina Daubel
    • Taija Mäkinen
    ResearchOpen Access
    Nature
    Volume: 641, P: 465-475

  • How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    • Rui Benedito
    News & Views
    Nature Cell Biology
    Volume: 23, P: 1109-1110

  • Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.

    • Erika Monelli
    • Pilar Villacampa
    • Mariona Graupera
    Research
    Nature Metabolism
    Volume: 4, P: 327-343

  • Notch signaling is critical for HSC emergence. Here, the authors identify a sub-set of hemogenic endothelial cells with high Notch activity that it is gradually shut down through cis inhibition of NOTCH1 by JAG1, and report that this process sustains HSC.

    • Roshana Thambyrajah
    • Maria Maqueda
    • Anna Bigas
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • De la Pompa and colleagues show that Dll4-mediated Notch signalling regulates trabeculation in the developing mouse endocardium, whereas Jag1/2-mediated Notch signalling in the myocardium drives compaction and ventricular maturation.

    • Gaetano D’Amato
    • Guillermo Luxán
    • José Luis de la Pompa
    Research
    Nature Cell Biology
    Volume: 18, P: 7-20