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Showing 1–15 of 15 results
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  • A synthetic route to GB18, an alkaloid from the bark of hallucinogenic Galbulimima sp., is developed, enabling its identification as an antagonist of κ- and μ-opioid receptors.

    • Stone Woo
    • Ryan A. Shenvi
    Research
    Nature
    Volume: 606, P: 917-921

  • Fischer carbenes are typically synthesized by addition of pyrophoric reagents to toxic metal carbonyls. Now access to α-siloxycarbenes from thioesters has been reported via reductive silylation of cobalt acyls, providing a platform to harness carbene reactivity from carboxylates via metal acyls and allowing several new reactions occur, including heterodimerization to acyloin-type products.

    • Lingran Kong
    • Kevin Zong
    • Ryan Shenvi
    Research
    Nature Chemistry
    P: 1-8

  • Concise routes to 25 naturally occurring picrotoxanes were devised using a virtual library of intermediate analogues triaged by reactivity; this approach can overcome challenges in the use of computers for synthesis design.

    • Chunyu Li
    • Ryan A. Shenvi
    Research
    Nature
    Volume: 638, P: 980-986

  • A chemical synthesis of (–)-jiadifenolide, a small molecule neurotrophin, has been achieved in eight steps. The route relies on a stereoselective coupling of two simple butenolides to build the entire skeleton in a single step and produce one gram of the target for broad distribution to the biomedical community.

    • Hai-Hua Lu
    • Michael D. Martinez
    • Ryan A. Shenvi
    Research
    Nature Chemistry
    Volume: 7, P: 604-607

  • A perspective is given on how an electrocatalytic approach, inspired by decades of energy storage studies, can be used in the context of efficient cobalt-hydride generation with a variety of applications in modern organic synthesis.

    • Samer Gnaim
    • Adriano Bauer
    • Phil S. Baran
    Research
    Nature
    Volume: 605, P: 687-695

  • Minor changes to complex structures can exert major influences on synthesis strategy and functional properties but synthetic difficulties can obstruct the exploration of natural product function. Here the authors explore two parallel series of picrotoxinin analogs and identify leads with selectivity between mammalian and insect ion channels.

    • Guanghu Tong
    • Samantha Griffin
    • Ryan A. Shenvi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Tertiary alcohols are displaced with a nitrogen nucleophile with stereoinversion and with high selectivity over less substituted alcohols, providing complementarity to the SN2 reaction and efficient access to nitrogenous marine terpenoids.

    • Sergey V. Pronin
    • Christopher A. Reiher
    • Ryan A. Shenvi
    Research
    Nature
    Volume: 501, P: 195-199

  • The ability of enzymes to direct the synthesis of complex natural products from simple starting materials is epitomized by terpene biosynthesis. Now, a supramolecular catalyst has been shown to mimic some of the reactivity of this process.

    • Jeremy J. Roach
    • Ryan A. Shenvi
    News & Views
    Nature Chemistry
    Volume: 7, P: 187-189

  • Much natural-product-based drug discovery has depended on the practices of Indigenous Peoples, who have sometimes invested centuries of care into the cultivation and use of plant or fungal matter. However, the contributions of the original discoverers can be lost as the natural products are developed into pharmaceutical products.

    • Khalyd J. Clay
    • Ryan A. Shenvi
    Comments & Opinion
    Nature Chemistry
    Volume: 16, P: 1735-1736

  • Although biaryl rings can be easily formed via cross coupling, their tetrahedral, high-fraction sp3 equivalents cannot. Now the scope, mechanism and biological profile of a general attached-ring synthesis has been probed. This provides direct access to full bridgehead substitution via sp3–sp3 coupling and enables rapid entry to natural product space.

    • Benjamin J. Huffman
    • Shuming Chen
    • Ryan A. Shenvi
    Research
    Nature Chemistry
    Volume: 12, P: 310-317

  • Sesquiterpenes are biosynthesized from linear isoprenols through the intermediacy of multiple, high-energy carbocations. Here a strategy is demonstrated for mimicking these reactions in bulk solvent to yield strained, acid-labile terpenes. Key to the success of these reactions is the sequestration of the counteranion away from the reactive carbocation, a strategy that should enable further study of challenging polycyclizations.

    • Sergey V. Pronin
    • Ryan A. Shenvi
    Research
    Nature Chemistry
    Volume: 4, P: 915-920

  • Gathering big datasets has become an essential component of machine learning in many scientific areas, but it is unavoidable that some data values are missing. An important and growing effect that needs careful attention, especially when heterogeneous data sources are combined, is that of structured missingness, where data values are missing not at random, but with a specific structure.

    • Robin Mitra
    • Sarah F. McGough
    • Ben D. MacArthur
    Reviews
    Nature Machine Intelligence
    Volume: 5, P: 13-23