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Showing 1–8 of 8 results
Advanced filters: Author: Ryan D. Kibler Clear advanced filters

  • A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.

    • Timothy F. Huddy
    • Yang Hsia
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 627, P: 898-904

  • Using viral capsid architectures as template for design, higher triangulation number nanocages that require symmetry breaking offer potential advances in targeted delivery and antigen-displaying vaccines.

    • Sangmin Lee
    • Ryan D. Kibler
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 638, P: 546-552

  • Deep learning-based generative tools are used to design protein building blocks with well-defined directional bonding interactions, allowing the generation of a variety of scalable protein assemblies from a small set of reusable subunits.

    • Shunzhi Wang
    • Andrew Favor
    • David Baker
    ResearchOpen Access
    Nature Materials
    Volume: 24, P: 1644-1652

  • Predictive protein design and experiments are combined to develop anisotropic bifaceted protein nanomaterials using pseudosymmetric hetero-oligomeric building blocks.

    • Sanela Rankovic
    • Kenneth D. Carr
    • Neil P. King
    ResearchOpen Access
    Nature Materials
    Volume: 24, P: 1635-1643

  • Hetero-oligomeric proteins offer many advantages for bioengineering efforts but are difficult to make from scratch. Here, authors present a simple method for creating pseudosymmetric hetero-oligomers from input symmetrical proteins.

    • Ryan D. Kibler
    • Sangmin Lee
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • This study reports the successful de novo design of a trefoil knotted protein fold for which the crystal structure agrees closely with the intended trefoil knot topology.

    • Lindsey A. Doyle
    • Brittany Takushi
    • Philip Bradley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Molecular systems with coincident cyclic and superhelical symmetry axes have considerable advantages for materials design as they can be lengthened or shortened by changing the length of the monomers. Now a systematic approach to generate modular repeat protein oligomers with combined symmetry that can be extended by repeat propagation has been developed.

    • Neville P. Bethel
    • Andrew J. Borst
    • David Baker
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1664-1671