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A metasurface is used to generalize the Rashba effect from circular polarizations to any polarization state for thermal emission.

Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed between the hippocampus and hypothalamus that enables the recall of cold-related memories.

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

A microfabrication methodology that involves thinning and deep etching of gadolinium gallium garnet substrates can be used to create magnetostatic wave resonators that exhibit a coupling of more than 8% in the 6–20 GHz frequency range.

Membranes can be used for energy efficient organic liquid mixture separations. Here the authors use machine learning and transport simulations to predict the separation of complex mixtures such as crude oils by any linear polymer membrane.

Arboviruses transmitted by Aedes mosquitoes have an expanding global distribution and identifying areas at risk is important for public health planning. Here, the authors present global disease maps for dengue, chikungunya, Zika and yellow fever through a multi-disease ecological niche modelling approach.

The properties of materials can be drastically modified under extreme pressure. Here the authors investigate ramp-compressed sodium to 5 million atmospheres with in situ X-ray diffraction and optical reflectivity, revealing a complex temperature-driven polymorphism and suggesting the formation of a previously predicted electride phase.

For fertilization, sperm migrate through the utero-tubal junction (UTJ) and bind to the zona pellucida (ZP). Here the authors identify sperm expressed GALNTL5 as a GalNAc binding factor required for migration though the UTJ and attachment to the ZP.

In this study, the authors show that gut dysbiosis in African children with severe malaria may contribute to the pathogenesis of malaria, including an increased risk of post-discharge mortality.

The authors reveal a mechanism for regulation of behaviour during approach avoidance conflicts that relies on two specialized, parallel circuits that allow bidirectional hippocampal control of the prefrontal cortex.

Deep learning-based generative tools are used to design protein building blocks with well-defined directional bonding interactions, allowing the generation of a variety of scalable protein assemblies from a small set of reusable subunits.

CryoDRGN-AI is a deep learning system for ab initio reconstruction of dynamic biomolecular complexes from cryo-electron microscopy and cryo-electron tomography imaging datasets.

Lin, Geng and colleagues identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy.

Here, the authors use a tapered optical fibre to create a dynamic, reversible strain in a suspended WSe₂ monolayer, and observe that dark excitons are funnelled to high-strain regions and are the principal participants in drift and diffusion at cryogenic temperatures.

Olfactory deficits occur early in Alzheimer’s disease (AD). Here, the authors identify that loss of locus coeruleus axons in the olfactory bulb underlies impaired olfaction in an AD mouse model and provide translational evidence for similar deficits in humans.

Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a mechanism that is independent of genes required for biofilm formation.

Glycans regulate cells via glycosylation, and aberrant glycosylation is linked to disease initiation and progression. Here, the authors present GlycanDIA, a DIA-based workflow enabling sensitive, precise glycan analysis, revealing low-abundant modifications and profiling distinct RNA glycan patterns with biological relevance.

Degradation—the loss of carbon stored in intact woodland—is very difficult to measure over large areas. Here, the authors show that carbon emissions from degradation in African woodlands greatly exceed those from deforestation, but are happening alongside widespread increases in biomass in remote areas.

One of the attractions in studying oxide heterostructures is the unusual physical phenomena that they enable. It is now demonstrated that the enforced cation ordering in thin oxide superlattices leads to significantly enhanced magnetic ordering temperatures.

Hybrid organic-inorganic trihalide perovskites can make remarkable optoelectronic devices but their spin characteristics are less investigated. Here Wang et al. show spin-polarized carriers injection into methylammonium lead bromide films with long lifetime and realize spin LEDs and spin valves.

Despite advances in additive manufacturing of piezoceramics, resultant transducers generally suffer from high porosity, weak piezoelectric responses, and limited geometry. Here, authors report the design and printing of fully packaged freeform ultrasonic transducers capable of traveling inside mm-sized channels and deliver localized high ultrasound energy.

Visium spatial transcriptomics, single-nucleus RNA sequencing and co-detection by indexing are used to identify distinct spatial microregions in tumours and their microenvironment across six diverse solid cancer types.

The pachycephalosaurian Zavacephale rinpoche, from the Early Cretaceous of Mongolia, provides crucial insights into the early evolution of dome-headed dinosaurs, including the development of the frontoparietal dome and decoupling of sociosexual and somatic maturity.

KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealing a co-evolutionary mechanism between retroviruses and host repressors.

The relationship between lipid dyshomeostasis and tau pathology in FTLD and AD remains unclear. Here, the authors demonstrate that GRAMD1B contributes to lipid dyshomeostasis, autophagy impairment, and tau hyperphosphorylation in neurons.

Charge programmed additive manufacturing seamlessly integrates multiple material classes and provides a universal platform for rapid printing of ultralight antennas. It propels discovery of antenna designs with unprecedented structural complexity.

The Southern Ocean is an important sink of carbon via the biological pump. Here authors run high-resolution physical/biogeochemical simulations of an open-Southern Ocean ecosystem forced with a realistic seasonal cycle and confirm that (sub)mesoscale iron transport across the mixing-layer base sustains primary productivity.

Tamm plasmon thermal emitters can provide low-cost, efficient mid to long infrared emission, but have been limited by a challenging design. Here the authors apply an inverse design protocol to demonstrate tailorable multi-band emission on CdO films.

Hepatitis C virus (HCV) uses a hybrid entry mechanism. Upon exposure to low pH, envelope glycoprotein E2 releases an internal loop into the host membrane. Here we show the amino terminal region is a critical determinant for membrane interaction, providing insights into the HCV entry mechanism.

Cooperative paramagnetism refers to a strongly correlated state without long range magnetic order that occurs in frustrated magnetic systems between the Neel temperature and Curie-Weiss temperature. Here, using resonant elastic magnetic and inelastic x-ray scattering, Terilli et al find a spectrally sharp gapped magnetic excitations that persists above the Neel temperature in Y₂Ir₂O₇, implying a cooperative paramagnetic phase.

Detection of radiation is important for environmental health and safety. Here the authors demonstrate a method for radiation detection and mapping in 2D using minimum number of detectors and inter-pixel padding to increase the contrast between pixels.

A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

Low-pressure wind tunnel experiments suggest that large sand ripples on Mars are drag ripples, not impact ripples. Windblown drag ripples constitute an untapped record of atmospheric evolution under tenuous atmospheres across the Solar System.

Integrated single mode lasers capable of extremely narrow linewidths and high output power will enable precision portable quantum, microwave, and sensing applications. Here we demonstrate a simultaneous record low fundamental linewidth and high output power using an integrated Brillouin laser in a meter-scale silicon nitride coil resonator.

Nanocavity optomechanical systems can exhibit strong dynamical back-action between mechanical motion and the cavity light field. Here, optical control of mechanical motion within two different nanocavity structures is demonstrated. A form of optically controlled mechanical transparency is also demonstrated, which is analogous to electromagnetically induced transparency.

Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.

Researchers experimentally demonstrate a fully integrated coherent optical neural network. The system, with six neurons and three layers, operates with a latency of 410 ps.

Meiotic HORMA domain proteins assemble to form chromosome axes that support crossing over and segregation. Here, the authors show that the assembly of these components into axes requires the TRiC chaperonin, revealing a nuclear role for protein folding.

Engineered living materials (ELMs) embed living cells in a biopolymer matrix to create novel materials with tailored functions. In this work, the authors engineered bacteria to grow novel macroscopic materials that can be reshaped, functionalized, and used to filter contaminated water while also showing that the stiffness of these materials can be tuned through genetic changes.

A large language model designed for health monitoring provides personalized sleep and fitness predictions, insights and advice.

Optical frequency combs in the mid-infrared are required for molecular gas detection applications but their realization in compact microresonator-based platforms is challenging. Here, Griffith et al. demonstrate on-chip broadband comb generation on a silicon microresonator spanning from 2.1 to 3.5 μm.

Soft hair arrays anchored to a substrate are useful for bio-inspired engineering applications. Here, the authors demonstrate a rapid 3D printing technique for creating fine, continuous, biomimetic hair arrays using solvent exchange. Fibers as small as 1.5 µm are printed at high speeds, offering scalability for biomimetic and structural applications.