This Review considers the endoscopic ablative techniques now available for use in the esophagus—photodynamic therapy, laser therapy, multi-polar electro-coagulation, argon plasma coagulation, endoscopic mucosal resection, radiofrequency ablation and cryotherapy. At present, photodynamic therapy is the only FDA-approved ablative modality for high-grade dysplasia in Barrett's esophagus, but, at this stage, it is not clear which technique will emerge as superior for the treatment of esophageal adencocarcinoma precursors.
