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Showing 1–50 of 54 results

Advanced filters: Author: Sachiko Watanabe Clear advanced filters

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

Masashi Adachi
Sachiko Suematsu
Shigekazu Nagata
Research01 Nov 1995
Nature Genetics

Volume: 11, P: 294-300
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Search for the origin of exotic helium in deep-sea sediments

Sachiko Amari
Minoru Ozima
Research01 Oct 1985
Nature

Volume: 317, P: 520-522
A New Type of Defect in the Gene for Bilirubin Uridine 5 '-Diphosphate-Glucuronosyltransferase in a Patient with Crigler-Najjar Syndrome Type I

Sachiko Aono
Yasukazu Yamada
Hiroshi Sato
Research01 Jun 1994
Pediatric Research

Volume: 35, P: 629-632
Microbiota-driven antitumour immunity mediated by dendritic cell migration

A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the activation of tumour-specific CD8⁺ T cells.

Nina Yi-Tzu Lin
Shota Fukuoka
Hiroyoshi Nishikawa
ResearchOpen Access14 Jul 2025
Nature

Volume: 644, P: 1058-1068
Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy

Takuya Iino
Manabu Nagao
Ryuji Toh
ResearchOpen Access03 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

Aquaporin-3 (AQP3) mediates cellular uptake of water and hydrogen peroxide (H₂O₂). Here, the authors show that TNF-induced H₂O₂enters keratinocytes via AQP3, eliciting NF-κB activation and the development of psoriasis, and identify AQP3 as a potential therapeutic target for this inflammatory immune-mediated disease.

Mariko Hara-Chikuma
Hiroki Satooka
A. S. Verkman
Research23 Jun 2015
Nature Communications

Volume: 6, P: 1-14
Carbonate record of temporal change in oxygen fugacity and gaseous species in asteroid Ryugu

The asteroid Ryugu experienced aqueous alteration under changing temperature and redox conditions, according to an isotopic analysis of secondary calcite and dolomite grains in samples from Ryugu obtained by the Hayabusa2 spacecraft.

Wataru Fujiya
Noriyuki Kawasaki
Hisayoshi Yurimoto
Research10 Jul 2023
Nature Geoscience

Volume: 16, P: 675-682
Generation of a synthetic lymphoid tissue–like organoid in mice

Sachiko Suematsu
Takeshi Watanabe
Research28 Nov 2004
Nature Biotechnology

Volume: 22, P: 1539-1545
Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation

Sachiko Seo
Yoshiaki Usui
Fumiya Wada
Research14 May 2021
Bone Marrow Transplantation

Volume: 56, P: 2410-2422
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

The production of chemoattractants in the pre-metastatic lung can be induced by distant primary tumours. The chemoattractants S100A8 and S100A9 induce serum amyloid A3 and TLR4 activation and cause an inflammation-like state that facilitates metastasis.

Sachie Hiratsuka
Akira Watanabe
Yoshiro Maru
Research28 Sept 2008
Nature Cell Biology

Volume: 10, P: 1349-1355
Enhanced lymphocyte infiltration in the liver of LDL receptor and Myeloid Differentiation 1 double knockout mice on high fat diet

Mrityunjoy Biswas
Susumu Tomono
Sachiko Akashi-Takamura
ResearchOpen Access23 Oct 2025
Scientific Reports

Volume: 15, P: 1-18
Association of CD4-positive cell infiltration with response to vedolizumab in patients with ulcerative colitis

Haruka Miyazaki
Namiko Hoshi
Yuzo Kodama
ResearchOpen Access20 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

A comparison of copper and zinc isotopic measurements between the Ryugu samples and various carbonaceous chondrites excludes any genetic link between the two except for the CI (Ivuna-type) chondrites. Ryugu-like material might have accounted for ~5% of Earth’s mass.

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Research12 Dec 2022
Nature Astronomy

Volume: 7, P: 182-189
Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

Miyuki Kubota
Motoko Kawashima
Kazuo Tsubota
ResearchOpen Access19 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci

Tumours are thought to pave the way for metastases to distant organs by secreting factors create regions of increased vascular permeability. Hiratsuka et al.identify innate immune pathways that underlie this process in the pre-metastatic lungs of tumour-bearing mice and patients.

Sachie Hiratsuka
Sachie Ishibashi
Yoshiro Maru
ResearchOpen Access14 May 2013
Nature Communications

Volume: 4, P: 1-10
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D

Motomichi Matsuzaki
Osami Misumi
Tsuneyoshi Kuroiwa
ResearchOpen Access08 Apr 2004
Nature

Volume: 428, P: 653-657
Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Amendments and Corrections14 Mar 2023
Nature Astronomy

Volume: 7, P: 633
Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay

Kohei Hamanaka
Atsushi Fujita
Naomichi Matsumoto
ResearchOpen Access26 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-12
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Clinical and genetic spectrum of patients with IRF2BPL syndrome

Kazuhiro Iwama
Mitsuhiro Kato
Naomichi Matsumoto
Research22 Jan 2025
Journal of Human Genetics

Volume: 70, P: 181-188
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Genome-specific association study (GSAS) for exploration of variability in hemp (Cannabis sativa)

Nina Trubanová
Sachiko Isobe
Susanne Schilling
ResearchOpen Access11 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Impacts of dental checkups on oral function among Japanese older adults

Tin Zar Tun
Kaung Myat Thwin
Hiroshi Ogawa
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-10
Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden

Xuefeng Wu
Tetsuhiro Yoshino
Masaru Mimura
ResearchOpen Access22 Jan 2024
Scientific Reports

Volume: 14, P: 1-10
Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies

Nobuhiko Imahashi
Seitaro Terakura
Takaya Mitsuyoshi
Research21 May 2020
Bone Marrow Transplantation

Volume: 55, P: 2098-2108
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Triple mosaic variants of PURA in a patient with multiple congenital anomalies

Atsushi Fujita
Yuta Suenaga
Naomichi Matsumoto
Research14 Jan 2025
Journal of Human Genetics

Volume: 70, P: 227-230
Identifying pathogenic variants in rare pediatric neurological diseases using exome sequencing

Kazuyuki Komatsu
Mitsuhiro Kato
Hirotomo Saitsu
ResearchOpen Access21 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31

Katsunari Namba
Mayumi Abe
Yasufumi Sato
Research20 Jan 2000
Oncogene

Volume: 19, P: 106-114
TIA-1 expression in hairy cell leukemia

Naoyoshi Mori
Yoshiko Idate Murakami
Toshiro Nagasawa
Research09 Apr 2004
Modern Pathology

Volume: 17, P: 840-846
Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia

Ryo Yanagiya
Yuji Miyatake
Ai Kotani
ResearchOpen Access24 Jun 2024
Leukemia

Volume: 38, P: 1731-1741
Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

Honami Echizen
Kenjiro Hanaoka
Yasuteru Urano
ResearchOpen Access30 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
RNA sequencing and target long-read sequencing reveal an intronic transposon insertion causing aberrant splicing

Ryota Kawakami
Takuya Hiraide
Hirotomo Saitsu
Research15 Dec 2023
Journal of Human Genetics

Volume: 69, P: 91-99
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Rita Alaggio
Catalina Amador
Wei-Li Zhao
Amendments and CorrectionsOpen Access19 Jul 2023
Leukemia

Volume: 37, P: 1944-1951
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis

Naohiro Yanagimura
Shinji Takeuchi
Seiji Yano
ResearchOpen Access28 Feb 2022
npj Precision Oncology

Volume: 6, P: 1-12
Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis

Erika Hishida
Homare Ito
Masafumi Takahashi
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-13
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

Naoya Yamada
Tadayoshi Karasawa
Masafumi Takahashi
ResearchOpen Access24 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-16
Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease

Jun Nakamura
Sachiko Watanabe
Masafumi Takahashi
ResearchOpen Access15 May 2018
Scientific Reports

Volume: 8, P: 1-13
Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells

Tadashi Yokoi
Taku Tanaka
Noriyuki Azuma
ResearchOpen Access01 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

Taku Tanaka
Tadashi Yokoi
Noriyuki Azuma
ResearchOpen Access10 Feb 2015
Scientific Reports

Volume: 5, P: 1-11
Discovery and Mechanistic Characterization of Selective Inhibitors of H₂S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

Kenjiro Hanaoka
Kiyoshi Sasakura
Tetsuo Nagano
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity

Catharina Sagita Moniaga
Sachiko Watanabe
Mariko Hara-Chikuma
ResearchOpen Access22 Oct 2015
Scientific Reports

Volume: 5, P: 1-13
Long-read sequencing revealing intragenic deletions in exome-negative spastic paraplegias

Hiromi Fukuda
Takeshi Mizuguchi
Naomichi Matsumoto
Research12 Jun 2023
Journal of Human Genetics

Volume: 68, P: 689-697
Draft genome sequence of subterranean clover, a reference for genus Trifolium

Hideki Hirakawa
Parwinder Kaur
Sachiko N. Isobe
ResearchOpen Access22 Aug 2016
Scientific Reports

Volume: 6, P: 1-9

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