Nature Search

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics such as charge and hydrophobicity.

Iris Langstein-Skora
Andrea Schmid
Alex S. Holehouse
ResearchOpen Access12 Feb 2026
Nature Cell Biology

Volume: 28, P: 323-337
Cardiovascular stent technologies for coronary and valvular heart disease: the potential of 3D printing for stent fabrication

In this Review, Emmert and colleagues provide an overview of the clinically available metallic and polymeric stents used to treat coronary artery disease and valvular heart disease, and discuss the manufacturing techniques used to fabricate these stents, with a focus on the emerging role of 3D-printing technologies.

Arian Ehterami
Sarah E. Motta
Maximilian Y. Emmert
Reviews27 Mar 2026
Nature Reviews Cardiology

P: 1-25
Emergence of lignin-carbohydrate interactions during plant stem maturation visualized by solid-state NMR

Solid-state NMR reveals that lignin-carbohydrate contact patterns, rather than lignin amount, shape the structure and property of plant cell walls, highlighting distinct roles of lignin and carbohydrate units during wall formation.

Peng Xiao
Sarah A. Pfaff
Tuo Wang
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Repeated behavioural evolution is associated with convergence of gene expression in cavity-nesting songbirds

The authors performed phylogenetically controlled behavioural assays and analysed brain transcriptomes across five avian families, identifying convergent patterns of gene expression associated with aggression and nesting behaviour in obligate cavity-nesting birds.

Sara E. Lipshutz
Mark S. Hibbins
Kimberly A. Rosvall
Research28 Apr 2025
Nature Ecology & Evolution

Volume: 9, P: 845-856
Independent infections of porcine deltacoronavirus among Haitian children

The presence of porcine deltacoronavirus has been detected in three children from Haiti that could have originated from zoonotic spillover.

John A. Lednicky
Massimiliano S. Tagliamonte
J. Glenn Morris Jr
ResearchOpen Access17 Nov 2021
Nature

Volume: 600, P: 133-137
Multispecies migratory connectivity indicates hemispheric-scale risk to bird populations from global change

On the basis of data from >329,000 migratory birds, this study presents multispecies migratory connectivity as a parameter representing exposure to global change and shows that connections between breeding regions in Canada and non-breeding regions in South America are at greatest risk from global change.

Sarah P. Saunders
William V. DeLuca
Chad B. Wilsey
Research17 Feb 2025
Nature Ecology & Evolution

Volume: 9, P: 491-504
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Adaptive responses of animals to climate change are most likely insufficient

It is unclear whether species’ responses to climate change tend to be adaptive or sufficient to keep up with climate change. Here, Radchuk et al. perform a meta-analysis showing that in birds phenology has advanced adaptively in some species, though not all the way to the new optima.

Viktoriia Radchuk
Thomas Reed
Stephanie Kramer-Schadt
ResearchOpen Access23 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Global gridded dataset of heating and cooling degree days under climate change scenarios

Accurate projections of heating and cooling needs are vital for planning energy use and achieving the sustainable development goals. A global dataset now maps global heating and cooling degree days, finding future hotspots, rising cooling demand and early shifts in energy needs with major global impacts.

Jesus Lizana
Nicole D. Miranda
Malcolm McCulloch
Research26 Jan 2026
Nature Sustainability

Volume: 9, P: 470-480
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Transgenes are inserted into human cells by 2-RNA delivery of a retroelement protein and template.

Xiaozhu Zhang
Briana Van Treeck
Kathleen Collins
ResearchOpen Access20 Feb 2024
Nature Biotechnology

Volume: 43, P: 42-51
A randomised controlled trial of the effect of automated interactive calling combined with a health risk forecast on frequency and severity of exacerbations of COPD assessed clinically and using EXACT PRO

David MG Halpin
Tish Laing-Morton
Penny Marno
Research17 Jun 2011
Primary Care Respiratory Journal

Volume: 20, P: 324-331
Change in cooling degree days with global mean temperature rise increasing from 1.5 °C to 2.0 °C

Failing to keep the increase of global mean temperature below 1.5 °C will have multiple negative implications. A study maps the annual changes in cooling demand, showing the most affected countries by warming, if the global mean temperature rises from 1.5 °C to 2.0 °C

Nicole D. Miranda
Jesus Lizana
Malcolm McCulloch
ResearchOpen Access13 Jul 2023
Nature Sustainability

Volume: 6, P: 1326-1330
Maternal iron deficiency perturbs embryonic cardiovascular development in mice

From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.

Jacinta I. Kalisch-Smith
Nikita Ved
Duncan B. Sparrow
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Author Correction: Change in cooling degree days with global mean temperature rise increasing from 1.5 °C to 2.0 °C

Nicole D. Miranda
Jesus Lizana
Malcolm McCulloch
Amendments and CorrectionsOpen Access25 Jul 2023
Nature Sustainability

Volume: 6, P: 1716
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

A genome-wide association study in more than 400,000 individuals identifies 139 new signals for lung function. These variants can predict chronic obstructive pulmonary disease in independent, transancestral cohorts.

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 481-493
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new. Integration of gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.

Phuwanat Sakornsakolpat
Dmitry Prokopenko
Loems Zeigler-Heitbrock
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 494-505
Datopotamab–deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial

In the I-SPY2.2 trial, patients with high-risk stage 2/3 breast cancer received neoadjuvant datopotamab–deruxtecan plus durvalumab, followed by sequential chemotherapy with or without targeted therapy, with the option of early surgical resection after each block of therapy, showing that de-escalation of therapy is possible for several patient subgroups without compromising outcome and avoiding toxicity of standard chemotherapy.

Rebecca A. Shatsky
Meghna S. Trivedi
Laura J. Esserman
Research14 Sept 2024
Nature Medicine

Volume: 30, P: 3737-3747
Human influence on climate in the 2014 southern England winter floods and their impacts

An ensemble of climate model simulations, as well as hydrological modelling and flood risk mapping, are used to show the role of anthropogenic warming on the extreme rainfall that caused the 2013/14 floods in southern England.

Nathalie Schaller
Alison L. Kay
Myles R. Allen
Research01 Feb 2016
Nature Climate Change

Volume: 6, P: 627-634
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.

Louise V Wain
Nick Shrine
Martin D Tobin
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 416-425
Trends in Europe storm surge extremes match the rate of sea-level rise

Analysis of tide gauge observations shows that, in contrast to the current assumption of stationary storm surge extremes in Europe, the surge contribution to changes in extreme sea levels since 1960 is similar to that of sea-level rise, influencing future coastal planning.

Francisco M. Calafat
Thomas Wahl
Sarah N. Sparrow
Research30 Mar 2022
Nature

Volume: 603, P: 841-845
Baroclinic Wave Simulation Ensemble: a Machine Learning ready dataset

Clément Bouvier
Joona Cornér
Victoria Anne Sinclair
ResearchOpen Access18 Nov 2025
Scientific Data

Volume: 12, P: 1-10
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Amendments and Corrections19 Apr 2024
Nature Genetics

Volume: 56, P: 1032-1033
Repeatability and degree of territorial aggression differs among urban and rural great tits (Parus major)

Samuel I. Hardman
Sarah Dalesman
ResearchOpen Access22 Mar 2018
Scientific Reports

Volume: 8, P: 1-12
Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh
Claire M Wade
Eric S. Lander
Research08 Dec 2005
Nature

Volume: 438, P: 803-819
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine
Anna L. Guyatt
Louise V. Wain
Amendments and Corrections20 May 2019
Nature Genetics

Volume: 51, P: 1067
Evolution of genes and genomes on the Drosophila phylogeny

An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

Andrew G. Clark
Michael B. Eisen
Iain MacCallum
Research08 Nov 2007
Nature

Volume: 450, P: 203-218
The effect of pupil dilation with tropicamide on vision and driving simulator performance

Theo Potamitis
Sarah V Slade
Philip I Murray
Research01 May 2000
Eye

Volume: 14, P: 302-306
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations.

Pascal Gellert
Corrinne V. Segal
Peter Donnelly
ResearchOpen Access09 Nov 2016
Nature Communications

Volume: 7, P: 1-11
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle

Luise A. Seeker
Sarah L. Underwood
Daniel H. Nussey
ResearchOpen Access10 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Vector coding reveals the underlying balance control strategies used by humans during translational perturbation

Naser Taleshi
James M. W. Brownjohn
Genevieve K. R. Williams
ResearchOpen Access05 Dec 2022
Scientific Reports

Volume: 12, P: 1-17
Higher CO₂ concentrations increase extreme event risk in a 1.5 °C world

A 1.5 °C temperature target can have varying atmospheric CO₂ concentrations associated with it. GCM simulations reveal CO₂ increases have a direct impact on climate extremes, highlighting the need for climate policy to complement temperature goals with CO₂ targets.

Hugh S. Baker
Richard J. Millar
Myles R. Allen
Research11 Jun 2018
Nature Climate Change

Volume: 8, P: 604-608
Ensemble of global climate simulations for temperature in historical, 1.5 °C and 2.0 °C scenarios from HadAM4

Jesús Lizana
Nicole D. Miranda
Malcolm D. McCulloch
ResearchOpen Access04 Jun 2024
Scientific Data

Volume: 11, P: 1-6
Response of winter climate and extreme weather to projected Arctic sea-ice loss in very large-ensemble climate model simulations

Kunhui Ye
Tim Woollings
James A. Screen
ResearchOpen Access17 Jan 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1-16
Ensemble of European regional climate simulations for the winter of 2013 and 2014 from HadAM3P-RM3P

Nathalie Schaller
Sarah N. Sparrow
Friederike E.L. Otto
ResearchOpen Access10 Apr 2018
Scientific Data

Volume: 5, P: 1-9
Author Correction: Response of winter climate and extreme weather to projected Arctic sea-ice loss in very large-ensemble climate model simulations

Kunhui Ye
Tim Woollings
James A. Screen
Amendments and CorrectionsOpen Access29 Jan 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1
Association between preterm brain injury and exposure to chorioamnionitis during fetal life

Devasuda Anblagan
Rozalia Pataky
James P. Boardman
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth

Saira Farooq
Shannon Leussink
Campbell Rolian
ResearchOpen Access05 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Accurate Learning with Few Atlases (ALFA): an algorithm for MRI neonatal brain extraction and comparison with 11 publicly available methods

Ahmed Serag
Manuel Blesa
James P. Boardman
ResearchOpen Access24 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring

To guide the safe implementation of the next generation of surgical robots, the IDEAL Robotics Colloquium provides recommendations for their evaluation throughout the product life cycle—considering multiple perspectives within and beyond the surgical team.

Hani J. Marcus
Pedro T. Ramirez
Arsenio Paez
Reviews19 Jan 2024
Nature Medicine

Volume: 30, P: 61-75
Neurocognitive function of 10-year-old multiples born less than 28 weeks of gestational age

J. Wells Logan
Elizabeth N. Allred
Kelly Vogt
Research21 Nov 2018
Journal of Perinatology

Volume: 39, P: 237-247
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472

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