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Showing 1–50 of 69 results

Advanced filters: Author: Satoko Chiba Clear advanced filters

Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial

A first-in-human clinical trial of iPS cell-derived invariant natural killer T cells in patients with recurrent head and neck cancer demonstrated safety and early signs of efficacy, showing tumor growth suppression and activation of immune pathways.

Tomohisa Iinuma
Tomoya Kurokawa
Shinichiro Motohashi
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2

Jianzhi Pan
Koji Nakade
Kazunari Yokoyama
ResearchOpen Access08 Oct 2009
Nature Precedings

P: 1
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention

This study identifies MAP3K8-driven MEK-ERK signaling as a key pathway in HTLV-1-associated myelopathy (HAM) and reveals virus-induced chromatin remodeling as its molecular basis, highlighting MAP3K8 as a promising therapeutic target.

Makoto Nakashima
Kaho Nagai
Yoshihisa Yamano
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-17
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Drawing boundaries between feasible and unfeasible zeolite intergrowths using high-throughput computational screening with synthesis validation

Determining the feasibility of intergrowths between zeolites is investigated using high-throughput atomistic simulations and experimental verification. Interfacial energy is an effective descriptor for identifying the feasibility of zeolite intergrowths and a zincosilicate zeolite intergrowth with three and nine rings is realized by hydrothermal syntheses.

Kota Oishi
Koki Muraoka
Akira Nakayama
Research20 Oct 2025
Nature Materials

Volume: 24, P: 1978-1984
Pan-cancer analysis of RNA expression signatures associated with cancer tissue architecture

Megumi Mogi
Katsushige Kawase
Masahito Kawazu
Research17 Oct 2025
British Journal of Cancer

Volume: 134, P: 141-154
Elevated uric acid levels as a risk factor for new-onset hypertension in newly enrolled Japanese university students (JSH46-0100)

Hiroyuki Terawaki
Ryuichi Yoshimura
Mayumi Yamamoto
Research12 Oct 2024
Hypertension Research

Volume: 48, P: 780-785
“Morning BP Action in Winter” initiative: confronting cardiovascular “heat shock”

Kazuomi Kario
Akira Nishiyama
Naoko Tomitani
Editorial14 Jan 2026
Hypertension Research

P: 1-6
EYA1 nonsense mutation in a Japanese branchio-oto-renal syndrome family

S. Usami
Satoko Abe
William J. Kimberling
Research01 Jul 1999
Journal of Human Genetics

Volume: 44, P: 261-265
Impact of myelodysplasia-related gene mutations and residual mutations at remission in venetoclax/azacitidine for AML

Yoshikazu Ikoma
Nobuhiko Nakamura
Yasuhito Nannya
ResearchOpen Access21 Apr 2025
Leukemia

Volume: 39, P: 1362-1367
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3

The UFM1 system, a ubiquitin-like conjugation system is crucial for endoplasmic reticulum (ER) homeostasis. Here, authors found that CYB5R3 is covalently conjugated with UFM1, which becomes a signal for ER-phagy, a selective autophagy of ER.

Ryosuke Ishimura
Afnan H. El-Gowily
Masaaki Komatsu
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-16
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis

Yasutaka Yamada
Rika Nishikawa
Naohiko Seki
Research01 Dec 2017
Journal of Human Genetics

Volume: 63, P: 195-205
A capsidless ssRNA virus hosted by an unrelated dsRNA virus

Most viral genomes and replicases are encased in a proteinaceous coat known as a capsid. Here, the authors identify a curious case of an obligate association between two RNA viruses in which one of the viruses misappropriates the capsid coat from the other, a process known as trans-encapsidation.

Rui Zhang
Sakae Hisano
Nobuhiro Suzuki
Research11 Jan 2016
Nature Microbiology

Volume: 1, P: 1-6
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H⁺-ATPases is essential for brain development in humans and mice

A member of the vacuolar H⁺-ATPase family, ATP6V0A1 is involved in lysosomal activity. Here, the authors report that ATP6V0A1 variants identified in individuals with developmental and epileptic encephalopathy are associated with impairment of lysosomal acidification, autophagy and mTORC1 signaling, suggesting an essential role of ATP6V0A1 in brain development.

Kazushi Aoto
Mitsuhiro Kato
Hirotomo Saitsu
ResearchOpen Access08 Apr 2021
Nature Communications

Volume: 12, P: 1-17
Importance of EQA/PT for the detection of genetic variants in comprehensive cancer genome testing

Kazuyuki Matsushita
Takayuki Ishige
Hirotaka Matsui
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

The accessory lentiviral protein X (Vpx) of the SIV_smm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.

Kei Miyakawa
Satoko Matsunaga
Akihide Ryo
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Yasuyuki Takamatsu
Satoko Koganemaru
Tatsuya Mima
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Identification of Antibiotic Clarithromycin Binding Peptide Displayed by T7 Phage Particles

Tetsuro Morimura
Naoko Noda
Fumio Sugawara
Research01 Oct 2006
The Journal of Antibiotics

Volume: 59, P: 625-632
Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay

Kohei Hamanaka
Atsushi Fujita
Naomichi Matsumoto
ResearchOpen Access26 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-12
Late-onset spastic ataxia phenotype in a patient with a homozygous DDHD2 mutation

Hiroshi Doi
Masao Ushiyama
Kunihiro Yoshida
ResearchOpen Access24 Nov 2014
Scientific Reports

Volume: 4, P: 1-7
Involvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice

Kazutoshi Murotomi
Shigeyuki Arai
Yoshihiro Nakajima
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation

Yoshitaka Gunji
Takayoshi Matsumura
Masafumi Takahashi
ResearchOpen Access27 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-13
Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy

Qingci Zhao
Ryoka Haga
Noritaka Nishida
ResearchOpen Access07 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

In human cells, invading pathogens trigger an innate immune response that helps prevent viral replication and spread. Here, the authors reveal a mechanism of innate immunity that selectively leads to the autophagic degradation of hepatitis B virus core protein.

Kei Miyakawa
Mayuko Nishi
Akihide Ryo
ResearchOpen Access27 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Integrated extracellular microRNA profiling for ovarian cancer screening

Screening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.

Akira Yokoi
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access17 Oct 2018
Nature Communications

Volume: 9, P: 1-10
Structural basis for two-way communication between dynein and microtubules

The movement of cytoplasmic dynein on microtubule tracks is coordinated by the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk. Here authors use NMR and cryo-EM and suggest that the communication between the ATPase-domain and MTBD is achieved by sliding of the stalk α-helix by a half-turn or one-turn.

Noritaka Nishida
Yuta Komori
Masahide Kikkawa
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Evolutionary histories of breast cancer and related clones

By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver alteration are shown, providing new insight into how breast cancer evolves.

Tomomi Nishimura
Nobuyuki Kakiuchi
Seishi Ogawa
ResearchOpen Access26 Jul 2023
Nature

Volume: 620, P: 607-614
Derivation of resident macrophages and construction of tumor microenvironment in Flk-1-knockout chimeric mice produced via blastocyst complementation

Satoko Ishii
Kazuto Yamazaki
Hiromitsu Nakauchi
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

Sarcomas are rare malignant tumours of bone and soft tissue whose diagnosis remain difficult. Here, the authors analyse serum samples from over 1000 patients and using separate discovery, training and validation cohorts, identify and validate a 7-microRNA index that distinguishes malignant sarcomas from benign disease.

Naofumi Asano
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-10
Death receptor 6 contributes to autoimmunity in lupus-prone mice

Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.

Daisuke Fujikura
Masahiro Ikesue
Toshimitsu Uede
ResearchOpen Access03 Jan 2017
Nature Communications

Volume: 8, P: 1-11
A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance

Glutamate transporters mediate neurotransmitter reuptake at glutamatergic synapses. Here the authors show that CDC42 effector protein CDC42EP4 supports efficient glutamate clearance by promoting the tethering of a glutamate transporter GLAST to perisynaptic clusters of septins in Bergmann glia.

Natsumi Ageta-Ishihara
Maya Yamazaki
Makoto Kinoshita
ResearchOpen Access10 Dec 2015
Nature Communications

Volume: 6, P: 1-16
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker

Yusuke Goto
Satoko Kojima
Naohiko Seki
ResearchOpen Access01 Sept 2015
British Journal of Cancer

Volume: 113, P: 1055-1065
Publisher Correction: Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Yusuke Okuno
Takayuki Murata
Hiroshi Kimura
Amendments and Corrections30 Jan 2019
Nature Microbiology

Volume: 4, P: 544
PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression

Histone citrullination by peptidylarginine deiminase 4 (PAD4) regulates transcription but its physiological role is unclear. Here Nakashima et al. show that PAD4 controls proliferation of multipotent haematopoietic cells by modulating c-myc expression.

Katsuhiko Nakashima
Satoko Arai
Toru Miyazaki
ResearchOpen Access14 May 2013
Nature Communications

Volume: 4, P: 1-8
A plant receptor-like kinase required for both bacterial and fungal symbiosis

Silke Stracke
Catherine Kistner
Martin Parniske
Research27 Jun 2002
Nature

Volume: 417, P: 959-962
Deregulation of a Ca²⁺/calmodulin-dependent kinase leads to spontaneous nodule development

Leïla Tirichine
Haruko Imaizumi-Anraku
Jens Stougaard
Research29 Jun 2006
Nature

Volume: 441, P: 1153-1156
Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: a retrospective cohort study

Makiko Fuyuki
Noriaki Usui
Sasagu Kimura
Research11 Nov 2020
Journal of Perinatology

Volume: 41, P: 814-823
Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer

Yusuke Goto
Akira Kurozumi
Naohiko Seki
ResearchOpen Access22 Jun 2017
British Journal of Cancer

Volume: 117, P: 409-420
Association between coffee and green tea intake and pneumonia among the Japanese elderly: a case-control study

Kyoko Kondo
Kanzo Suzuki
Chizuko Sumida
ResearchOpen Access10 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer

Satoko Kojima
Hideki Enokida
Naohiko Seki
Research28 Nov 2013
Journal of Human Genetics

Volume: 59, P: 78-87
Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer

Miki Fuse
Satoko Kojima
Naohiko Seki
Research02 Aug 2012
Journal of Human Genetics

Volume: 57, P: 691-699
An inhibitory role of Arg-84 in anion channelrhodopsin-2 expressed in Escherichia coli

Satoko Doi
Takashi Tsukamoto
Yuki Sudo
ResearchOpen Access02 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer

Yusuke Goto
Satoko Kojima
Naohiko Seki
ResearchOpen Access12 Apr 2016
British Journal of Cancer

Volume: 114, P: 1135-1144
An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

Shiho Chiba
Maki Kiso
Yoshihiro Kawaoka
ResearchOpen Access14 Oct 2024
npj Vaccines

Volume: 9, P: 1-5

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