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Bio-based oxalic acid production in Issatchenkia orientalis enables sustainable rare earth recovery

The growing demand for rare earth elements (REEs) underscores the need for sustainable recovery methods and a reliable supply. Here the authors establish a platform using a yeast to produce bio-oxalic acid for REE recovery, achieving 99% REE recovery from low-grade ore.

Jingxia Lu
Wenjun Guo
Huimin Zhao
ResearchOpen Access30 Jan 2026
Nature Communications

P: 1-11
High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis

3-Hydroxypropionic acid (3HP) is a top Department of Energy value-added chemical and precursor to bioplastics, yet cost-effective microbial bioproduction remains elusive. Here the authors establish efficient 3HP production in an acid tolerant yeast and validate its financially viability.

Shih-I Tan
Sarang S. Bhagwat
Huimin Zhao
ResearchOpen Access09 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis

An inadequate supply of cofactors often limits the production of target molecules in metabolic engineering. Here, the authors report cofactor engineering through decompartmentalization of the yeast mitochondrial metabolism to improve succinic acid production in Issatchenkia orientalis.

Vinh G. Tran
Shih-I Tan
Huimin Zhao
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Author Correction: An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

Vinh G. Tran
Somesh Mishra
Huimin Zhao
Amendments and CorrectionsOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1
Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

Mitochondria play a key role in cellular metabolism. Here, authors develop a Variational Autoencoder to design novel mitochondrial targeting sequences, validating them across several eukaryotic organisms and demonstrating their utility in metabolic engineering and protein delivery.

Aashutosh Girish Boob
Shih-I Tan
Huimin Zhao
ResearchOpen Access04 May 2025
Nature Communications

Volume: 16, P: 1-16
An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

Microbial production of succinic acid at an industrially relevant scale has been hindered by high downstream processing costs arising from neutral pH fermentation. Here, the authors report an end-to-end pipeline for succinic acid production at low pH using engineered acid-tolerant Issatchenkia orientalis strain.

Vinh G. Tran
Somesh Mishra
Huimin Zhao
ResearchOpen Access03 Oct 2023
Nature Communications

Volume: 14, P: 1-14

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Bio-based oxalic acid production in Issatchenkia orientalis enables sustainable rare earth recovery

High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis

Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis

Author Correction: An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

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Bio-based oxalic acid production in Issatchenkia orientalis enables sustainable rare earth recovery

High yield production of 3-hydroxypropionic acid using Issatchenkia orientalis

Decompartmentalization of the yeast mitochondrial metabolism to improve chemical production in Issatchenkia orientalis

Author Correction: An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis

Search

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