Liang Guang et al revealed that cardiac CDK9 is activated in hypertrophic myocardium and directly binds to NF-κB P65, promoting its phosphorylation to drive inflammation and remodeling. This finding identifies CDK9 as a potential therapeutic target for hypertrophic cardiomyopathy.
- Shiju Ye
- Yanbo Zhao
- Guang Liang