Sepsis-associated encephalopathy (SAE) is a severe and often fatal consequence of sepsis. Here authors show in a mouse model of sepsis that γδ T17 cells, migrating from the small intestine to the meninges, play a pathological role via activation of STING in microglia, leading to an increase in C1q-tagged synapses, which are subsequently pruned.
- Yuming Wu
- Yujing Zhang
- Jiancheng Zhang
