Nature Search

Retraction Note: RNA m⁶A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

Xinyao Lin
Guoshi Chai
Hongsheng Wang
Amendments and CorrectionsOpen Access16 Nov 2023
Nature Communications

Volume: 14, P: 1
Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma

Demeng Chen
Zhiqiang Zhao
Yi-Zhou Jiang
ResearchOpen Access04 Apr 2018
Bone Research

Volume: 6, P: 1-7
N⁶-methyladenosine (m⁶A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation

RNA modifications have emerged as important regulators of RNA function. In this study, Peng, Chen, Wei and Guo et al. show that the 18S rRNA N⁶-methyladenosine methyltransferase complex METTL5–TRMT112 regulates hepatic lipid metabolism and contributes to hepatocellular carcinoma.

Hao Peng
Binbin Chen
Shuibin Lin
Research23 Aug 2022
Nature Metabolism

Volume: 4, P: 1041-1054
N⁶-methyladenosine regulates glycolysis of cancer cells through PDK4

Dysregulation of N6-Methyladenosine (m⁶A) is associated with cancer progression. Here, authors show that m⁶A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells

Zihan Li
Yanxi Peng
Hongsheng Wang
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-16
Aberrant METTL1-mediated tRNA m⁷G modification alters B-cell responses in systemic autoimmunity in humans and mice

An effective B cell response requires a rapid increase in protein synthesis. Using multi-omics approaches, here the authors show that the methyltransferase METTL1 drives B cell activation via the tRNA m⁷G modification-dependent translation of BCR signaling and that aberrant METTL1 causes B cell autoreactivity in humans and mice, thus serving as a therapeutic target in systemic autoimmunity.

Shuyi Wang
Hui Han
Hui Zhang
ResearchOpen Access05 Dec 2024
Nature Communications

Volume: 15, P: 1-25
RETRACTED ARTICLE: RNA m⁶A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

RNA m6A methylation is known to be dysregulated in many cancers. Here, the authors show that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition.

Xinyao Lin
Guoshi Chai
Hongsheng Wang
ResearchOpen Access06 May 2019
Nature Communications

Volume: 10, P: 1-13
The tRNA methyltransferase Mettl1 governs ketogenesis through translational regulation and drives metabolic reprogramming in cardiomyocyte maturation

Du et al. elucidate the mechanism by which Mettl1, a tRNA m⁷G methyltransferase, regulates cardiomyocyte maturation by influencing the translation of the rate-limiting ketogenesis enzyme Hmgcs2, thereby impacting cardiomyocyte fuel utilization.

Tailai Du
Yanchuang Han
Zhan-Peng Huang
Research25 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1438-1453
Methyltransferases modulate RNA stability in embryonic stem cells

Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N⁶-methyladenosine (m⁶A) RNA modification in embryonic stem cells (ESCs). This m⁶A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.

Shuibin Lin
Richard I. Gregory
News & Views31 Jan 2014
Nature Cell Biology

Volume: 16, P: 129-131
N⁷-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Deregulation of METTL1-mediated N7- methylguanosine tRNA modification can promote oncogenesis. Here, the authors report that this modification regulates the translation of proteins in both the mTOR and negative regulators of autophagy pathways, resulting in the progression of esophageal squamous cell carcinoma.

Hui Han
Chunlong Yang
Shuibin Lin
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-15
mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

METTL3, the enzyme responsible for m⁶A modification, influences translation by interacting with eIF3h to mediate looping between the regions near the stop codon and 5′ cap of mRNA.

Junho Choe
Shuibin Lin
Richard I. Gregory
Research19 Sept 2018
Nature

Volume: 561, P: 556-560
CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer

Tumor associated macrophages (TAM) are playing an active role in tumor immune evasion in multiple cancer type. Here authors show that CD276 expression by TAMs may underpin this immune-suppressive role via promoting efferocytosis and suppressing MHC class II expression, which result in decreased CD4+ and CD8 + T cell infiltration.

Maosheng Cheng
Shuang Chen
Liang Peng
ResearchOpen Access01 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Reaction-passivation mechanism driven materials separation for recycling of spent lithium-ion batteries

Separating active cathode materials from current collectors poses a critical challenge in battery recycling. Here, the authors develop a facile strategy that relies on a reaction-passivation mechanism to effectively separate the aluminum foil and cathode active material in spent lithium-ion batteries.

Zihe Chen
Ruikang Feng
Yongming Sun
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-9
Mettl3-mediated m⁶A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m⁶A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.

Yunshu Wu
Liang Xie
Quan Yuan
ResearchOpen Access14 Nov 2018
Nature Communications

Volume: 9, P: 1-12
MicroRNA biogenesis pathways in cancer

The microRNA (miRNA) biogenesis pathway is frequently altered in cancer, leading to global downregulation of miRNA levels in some cancer types. This Review discusses the alterations that affect miRNA biogenesis in cancer.

Shuibin Lin
Richard I. Gregory
Reviews22 May 2015
Nature Reviews Cancer

Volume: 15, P: 321-333
RNA modification-mediated mRNA translation regulation in liver cancer: mechanisms and clinical perspectives

RNA modifications are crucial in regulating mRNA translation. This Review provides a comprehensive overview of the molecular mechanisms underlying RNA modifications in mRNA translation regulation, and discusses the diagnostic and therapeutic potentials of targeting RNA modifications for liver cancer management.

Shuibin Lin
Ming Kuang
Reviews19 Jan 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 267-281
PABPN1-C5 axis promotes hepatocellular carcinoma progression via NF-κB activation

Siyao Guo
Qiang Zhang
Canfeng Zhang
Research28 Jul 2025
Oncogene

Volume: 44, P: 3512-3524
Nucleotide resolution profiling of m⁷G tRNA modification by TRAC-Seq

tRNA modifications are important for normal and disease states, but methods to study them are lacking. This protocol relies on chemical cleavage at 7-methylguanosine (m⁷G) sites, followed by sequencing, to precisely map these modifications genome-wide.

Shuibin Lin
Qi Liu
Richard I. Gregory
Protocols16 Oct 2019
Nature Protocols

Volume: 14, P: 3220-3242
METTL1/WDR4-mediated tRNA m⁷G modification and mRNA translation control promote oncogenesis and doxorubicin resistance

Zhaoyu Wang
Peng Yu
Shuibin Lin
Research25 Apr 2023
Oncogene

Volume: 42, P: 1900-1912
Dynamic m⁶A mRNA methylation reveals the role of METTL3-m⁶A-CDCP1 signaling axis in chemical carcinogenesis

Fan Yang
Huan Jin
Weidong Ji
ResearchOpen Access22 Feb 2019
Oncogene

Volume: 38, P: 4755-4772
Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells

Mingqing Wu
Lu Sheng
Yang Li
Research27 Mar 2019
Oncogene

Volume: 38, P: 5425-5439
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells

Zirong Chen
Shuibin Lin
Lizi Wu
Research22 Jan 2018
Oncogene

Volume: 37, P: 1885-1895

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