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An eNOS-like nanomaterial for specific reversal of cerebral ischemia-reperfusion injury

Nitric oxide in known to have a protective effect in cerebrovascular disease. Here, the authors report on MoS₂ an eNOS mimetic which releases NO while avoiding toxic ONOO^- production, demonstrating therapeutic effects in inhibiting several damage pathways in cerebral ischemia-reperfusion injury.

Shuya Wang
Yuting Xiang
Kelong Ai
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-20
Snapshots of tRNA sulphuration via an adenylated intermediate

Molecular 'snapshots' of the MnmA thiouridylase–tRNA complex reveal that during RNA sulphuration, a key α-helix forms around the active site, burying U34 into the catalytic pocket. This 'closed' conformation of the active site ensures that sulphur is incorporated into uridine at the correct place.

Tomoyuki Numata
Yoshiho Ikeuchi
Osamu Nureki
Research27 Jul 2006
Nature

Volume: 442, P: 419-424
Complete crystallographic analysis of the dynamics of CCA sequence addition

A series of crystallographic 'snapshots' of tRNA maturase reveals the molecular changes in the enzyme that holds it in place on the tRNA, accommodating incoming CTP and ATP nucleotides, and allowing repositioning of the active site after each of the first two CMP residues are added.

Kozo Tomita
Ryuichiro Ishitani
Osamu Nureki
Research15 Oct 2006
Nature

Volume: 443, P: 956-960
Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice

Myocardial infarction (MI) is the most common emergent manifestation of cardiovascular diseases. Here, the authors designed a nanomedicine that can reprogram MI microenvironment by converting the detrimental substances (H+, ROS and hypoxia) into beneficial elements (O2 and H2O), as such demonstrates promising potential for the clinical application.

Yamei Liu
Shuya Wang
Yongping Bai
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Dual-scale chemical ordering for cryogenic properties in CoNiV-based alloys

Dual-scale chemical ordering in CoNiV-based alloys improves the synergy of strength and ductility at cryogenic temperatures, providing an approach for obtaining high-performance metallic materials for cryogenic applications.

Tiwen Lu
Binhan Sun
Shan-Tung Tu
ResearchOpen Access27 Aug 2025
Nature

Volume: 645, P: 385-391
ViT-HVE: a vision transformer-based framework for recognition and weighted evaluation of cultural heritage values

Wenlun Xu
Bo Huang
Pengyue Yan
ResearchOpen Access12 Nov 2025
npj Heritage Science

Volume: 13, P: 1-18
Characterization and identification of Chinese historical rubbings preserved in Wuyuan Museum by Pyrolysis–Gas Chromatography/Mass Spectrometry

Na Yao
Xiangsheng Zhan
Shuya Wei
ResearchOpen Access24 Sept 2021
Heritage Science

Volume: 9, P: 1-9
Salivary apoptotic microvesicles as biomarkers for prognostic non-healing oral ulcers and oral cancer: a cross-sectional study

Jian Zhao
Yu Dong
Luanjun Tan
ResearchOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Structural basis for template-independent RNA polymerization

Kozo Tomita
Shuya Fukai
Osamu Nureki
Research05 Aug 2004
Nature

Volume: 430, P: 700-704
Structural basis for anticodon recognition by methionyl-tRNA synthetase

Kotaro Nakanishi
Yuri Ogiso
Osamu Nureki
Research11 Sept 2005
Nature Structural & Molecular Biology

Volume: 12, P: 931-932
Crystal structure of the MgtE Mg²⁺ transporter

The crystal structure of a member of the MgtE family of Mg²⁺ transporters at 3.5Å resolution, and the structure of just the cytoplasmic domain in the presence and absence of Mg²⁺ is described. An elegant gating mechanism involving negative feedback by Mg²⁺ is also proposed.

Motoyuki Hattori
Yoshiki Tanaka
Osamu Nureki
Research15 Aug 2007
Nature

Volume: 448, P: 1072-1075
Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter

Iron is an essential mineral in plant physiology. YS1 transporter imports iron–phytosiderophore complex (Fe(III)–DMA) from the soil. Here, the authors describe the cryo-EM structures of barley YS1 in complex with substrate, and a synthetic substrate analog.

Atsushi Yamagata
Yoshiko Murata
Mikako Shirouzu
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-12
Structure and function of a membrane component SecDF that enhances protein export

Tomoya Tsukazaki
Hiroyuki Mori
Osamu Nureki
Research11 May 2011
Nature

Volume: 474, P: 235-238
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase

Yoshiaki Kise
Sang Won Lee
Osamu Nureki
Research11 Jan 2004
Nature Structural & Molecular Biology

Volume: 11, P: 149-156
Conformational transition of Sec machinery inferred from bacterial SecYE structures

A crystal structure of SecY bound to an anti SecY Fab fragment revealing a pre-open state of the channel is presented.

Tomoya Tsukazaki
Hiroyuki Mori
Osamu Nureki
Research16 Oct 2008
Nature

Volume: 455, P: 988-991
BCAP31, a cancer/testis antigen-like protein, can act as a probe for non-small-cell lung cancer metastasis

Jing Wang
Dongbo Jiang
Kun Yang
ResearchOpen Access04 Mar 2020
Scientific Reports

Volume: 10, P: 1-14
Activation of Ca²⁺-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells

Jie Gu
Shuya Dai
Haifeng Shi
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Biodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging

Qiang Liu
Shuya Zhou
Youchun Wang
ResearchOpen Access15 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
A soft magnetoelectric finger for robots’ multidirectional tactile perception in non-visual recognition environments

Yizhuo Xu
Shanfei Zhang
Bin Su
ResearchOpen Access04 Jan 2024
npj Flexible Electronics

Volume: 8, P: 1-11
Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection

Akihisa Shimizu
Ai Kawana-Tachikawa
Aikichi Iwamoto
ResearchOpen Access06 Nov 2013
Scientific Reports

Volume: 3, P: 1-9
A general quantum algorithm for numerical integration

Guoqiang Shu
Zheng Shan
Shuya Wang
ResearchOpen Access07 May 2024
Scientific Reports

Volume: 14, P: 1-9
Unveiling the piezoelectric nature of polar α-phase P(VDF-TrFE) at quasi-two-dimensional limit

Jun Qian
Sai Jiang
Yun Li
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-9

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