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Showing 1–50 of 55 results

Advanced filters: Author: Siddharth Singh Clear advanced filters

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes

3’ untranslated regions (3’UTRs) play a crucial role in regulating gene expression, but our 3’UTR catalogue is incomplete. Here, the authors develop a machine learning-based framework to predict previously unannotated 3’UTRs in 39 human tissues.

Siddharth Sethi
David Zhang
Juan A. Botia
ResearchOpen Access27 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

In this work, the authors report Cryo-EM imaging revealing diversity in amyloid fibril structures among ATTR patients with the same genetic mutation I84S. Further study is warranted to grasp the implications in ATTR amyloidosis pathology.

Binh An Nguyen
Virender Singh
Lorena Saelices
ResearchOpen Access17 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Author Correction: Mapping genetic diversity with the GenomeIndia project

Chandrika Bhattacharyya
Krithika Subramanian
Bratati Kahali
Amendments and Corrections08 May 2025
Nature Genetics

Volume: 57, P: 1563
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors

The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1 activation ameliorates ventricular enlargement and neuronal deficits.

Tyrone DeSpenza Jr.
Emre Kiziltug
Kristopher T. Kahle
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 536-557
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

NKG7 is a molecule well associated with NK cells but of unknown function. Engwerda and colleagues demonstrate that NKG7 is also associated with T_H1 cells and is essential for type I and cytotoxic responses.

Susanna S. Ng
Fabian De Labastida Rivera
Christian R. Engwerda
Research24 Aug 2020
Nature Immunology

Volume: 21, P: 1205-1218
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Susanna S. Ng
Fabian De Labastida Rivera
Christian R. Engwerda
Amendments and Corrections15 Feb 2024
Nature Immunology

Volume: 25, P: 716
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Evaluating the impact of pre-slaughter transport stress on broiler welfare and meat quality in India

Siddharth Mohan
Monika Madheshwaran
Yazavinder Singh
ResearchOpen Access12 Nov 2025
Scientific Reports

Volume: 15, P: 1-11
Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP

c-di-GMP has emerged as the signal controlling development in antibiotic producing Streptomyces. Here the authors describe another developmental role of c-di-GMP, in energy metabolism, by activating the glycogen-debranchingenzyme, GlgX. Structures revealing the activation mechanism are described.

Maria A. Schumacher
Mirka E. Wörmann
Natalia Tschowri
ResearchOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1-14
Exploring the potential of nano-enhanced lemongrass biodiesel blends with hydrogen premixing for improved CI engine behaviour

Krupakaran Radhakrishnan Lawrence
Praveen Anchupogu
Artūras Kilikevičius
ResearchOpen Access30 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

Polymeric nanoparticles can efficiently deliver siRNAs to endothelial cells in vivo and silence multiple genes for weeks.

James E. Dahlman
Carmen Barnes
Daniel G. Anderson
Research11 May 2014
Nature Nanotechnology

Volume: 9, P: 648-655
Mapping genetic diversity with the GenomeIndia project

The rich ethnolinguistic and sociocultural differences that exist in India offers a unique opportunity to study human diversity. With the whole genomes of 10,000 healthy and unrelated Indians from 83 populations, the GenomeIndia project captures the genetic diversity of one of the highly underrepresented populations in the global genomics landscape.

Chandrika Bhattacharyya
Krithika Subramanian
Bratati Kahali
Comments & Opinion08 Apr 2025
Nature Genetics

Volume: 57, P: 767-773
O-arm navigated excision and vertebroplasty of pediatric aggressive vertebral hemangioma with compressive myelopathy: A case report

Ajay R. Kothari
Nishad V. Situt
Parag K. Sancheti
Research22 Jul 2025
Spinal Cord Series and Cases

Volume: 11, P: 1-5
Binding Pattern Determination Of Class of Antifungal Drugs

Arpit Tandon
A Naqvi
Siddharth Sinha
MultimediaOpen Access29 Mar 2010
Nature Precedings

P: 1
Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer

Amrinder Singh
Neha Deshpande
Hanudatta S. Atreya
ResearchOpen Access16 Feb 2018
Scientific Reports

Volume: 8, P: 1-8
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Chemopreventive strategies in hepatocellular carcinoma

In light of the high mortality rate associated with hepatocellular carcinoma (HCC), chemopreventive strategies to prevent or delay the development of this disease are attractive. This Review outlines advances in the field of HCC chemoprevention, in particular focusing on the potential of antiviral therapy against HBV and HCV, the cancer-modifying effects of statins, antidiabetic medications and aspirin, as well as dietary strategies.

Siddharth Singh
Preet Paul Singh
William Sanchez
Reviews13 Aug 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 45-54
Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

Obesity affects 15–40% of patients with IBD. Here, Singh and colleagues discuss the evidence linking obesity to IBD pathogenesis, the effect of obesity on disease outcomes and treatment response, and obesity-related issues in abdominal imaging and IBD surgery.

Siddharth Singh
Parambir S. Dulai
William J. Sandborn
Reviews30 Nov 2016
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 110-121
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Optimization of regeneration and Agrobacterium-mediated transformation of Stevia (Stevia rebaudiana Bertoni): a commercially important natural sweetener plant

Pooja Taak
Siddharth Tiwari
Bhupendra Koul
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation

Sidhartha Singh
Navneet Singh
Siddharth Sharma
ResearchOpen Access13 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Epidemiology, risk factors and management of cardiovascular diseases in IBD

Patients with IBD might be at increased risk of cardiovascular disease and stroke. This Review discusses the epidemiology, pathophysiology, risk factors (in particular, the role of IBD activity and IBD-related medications) and management of cardiovascular disease in patients with IBD. The potential effects of cardiovascular medications on IBD are also discussed.

Siddharth Singh
Iftikhar J. Kullo
Edward V. Loftus Jr
Reviews02 Dec 2014
Nature Reviews Gastroenterology & Hepatology

Volume: 12, P: 26-35
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Performance behaviour of agro-waste based gypsum hollow blocks for partition walls

Siddharth Singh
Soumitra Maiti
Soraj Kumar Panigrahi
ResearchOpen Access25 Feb 2022
Scientific Reports

Volume: 12, P: 1-16
Positioning therapies for the management of inflammatory bowel disease

A careful integration of the effectiveness and safety of the therapies for inflammatory bowel disease, considering patients’ disease risks, treatment complications and preferences, is warranted to inform the positioning of therapies in clinical practice. Precision medicine might help choose the best option for an individual patient.

Siddharth Singh
Comments & Opinion27 Jan 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 411-412
Effect of heterologous intranasal iNCOVACC^® vaccination as a booster to two-dose intramuscular Covid-19 vaccination series: a randomized phase 3 clinical trial

Venkateshwar et al., explored the effect of Heterologous intranasal iNCOVACC® vaccination as a booster to two-dose intramuscular Covid-19 vaccinations (either by Covishield or Covaxin) in a controlled, randomised, open-label phase 3 clinical trial. This study also aimed to compare these results with homologous booster vaccinations by Covishield or Covaxin.

Venkateshwar Rao Akula
Amit Suresh Bhate
Sai. D Prasad
ResearchOpen Access23 Apr 2025
Communications Medicine

Volume: 5, P: 1-12
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Petal abscission in fragrant roses is associated with large scale differential regulation of the abscission zone transcriptome

Priya Singh
Neeraj Bharti
Aniruddha P. Sane
ResearchOpen Access14 Oct 2020
Scientific Reports

Volume: 10, P: 1-16
Prevalence and architecture of de novo mutations in developmental disorders

Whole-exome analysis of individuals with developmental disorders shows that de novo mutations can equally cause loss or altered protein function, but that most mutations causing altered protein function have not yet been described.

Jeremy F. McRae
Stephen Clayton
Matthew E. Hurles
Research25 Jan 2017
Nature

Volume: 542, P: 433-438
Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin^®)

Chandramani Singh
Savita Verma
Krishna Mohan Vadrevu
ResearchOpen Access18 Aug 2023
npj Vaccines

Volume: 8, P: 1-9
Large CO₂ reduction and enhanced thermal performance of agro-forestry, construction and demolition waste based fly ash bricks for sustainable construction

Siddharth Singh
Soumitra Maiti
Sameer Yadav
ResearchOpen Access10 Apr 2024
Scientific Reports

Volume: 14, P: 1-20
The impact of short-duration precipitation events over the historic Cauvery basin: a study on altered water resource patterns and associated threats

Satyajit Ghosh
Dillip Kumar Barik
Srichander Akunuri
ResearchOpen Access29 Aug 2023
Scientific Reports

Volume: 13, P: 1-16
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Matthew Hurles and colleagues report exome sequencing of 1,891 individuals with syndromic or nonsyndromic congenital heart defects (CHD). They found that nonsyndromic CHD patients were enriched for protein-truncating variants in CHD-associated genes inherited from unaffected parents and identified three new syndromic CHD disorders caused by de novo mutations.

Alejandro Sifrim
Marc-Phillip Hitz
Matthew E Hurles
Research01 Aug 2016
Nature Genetics

Volume: 48, P: 1060-1065
Persistence of immunity and impact of third dose of inactivated COVID-19 vaccine against emerging variants

Krishna Mohan Vadrevu
Brunda Ganneru
Krishna Ella
ResearchOpen Access14 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance

Subhashini Srinivasan
Chaitali Ghosh
Suresh Subramani
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-13
Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation

Atchuta Srinivas Duddu
Elizabeth Andreas
Mohit Kumar Jolly
ResearchOpen Access24 Oct 2024
npj Systems Biology and Applications

Volume: 10, P: 1-12
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

Jashodeep Datta
Anna Bianchi
Nipun B. Merchant
Research14 Jun 2022
Oncogene

Volume: 41, P: 3640-3654
Allogeneic blood or marrow transplantation with haploidentical donor and post-transplantation cyclophosphamide in patients with myelofibrosis: a multicenter study

Siddharth Kunte
Lisa Rybicki
Tania Jain
Research18 Oct 2021
Leukemia

Volume: 36, P: 856-864
Mechanistic insights into the host-microbe interaction and pathogen exclusion mediated by the Mucus-binding protein of Lactobacillus plantarum

Kumar Siddharth Singh
Sudarshan Kumar
Jai Kumar Kaushik
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Flux-flow instability across Berezinskii Kosterlitz Thouless phase transition in KTaO₃ (111) based superconductor

Nature of energy dissipation processes in two dimensional superconductors at high current drives remain largely unexplored. In this study, the authors investigate this for an interfacial superconductor and find distinct behaviours across the Berezinskii Kosterlitz Thouless phase transition.

Shashank Kumar Ojha
Prithwijit Mandal
Srimanta Middey
ResearchOpen Access05 Jun 2023
Communications Physics

Volume: 6, P: 1-9
mtDNA germ line variation mediated ROS generates retrograde signaling and induces pro-cancerous metabolic features

Rajnish Kumar Singh
Archita Srivastava
Rameshwar N. K. Bamezai
ResearchOpen Access10 Oct 2014
Scientific Reports

Volume: 4, P: 1-10
BAC-pool sequencing and analysis confirms growth-associated QTLs in the Asian seabass genome

Xueyan Shen
Si Yan Ngoh
László Orbán
ResearchOpen Access08 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Two-dimensional transition metal dichalcogenides assisted biofunctionalized optical fiber SPR biosensor for efficient and rapid detection of bovine serum albumin

Siddharth Kaushik
Umesh K. Tiwari
Ravindra K. Sinha
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-11
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709

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