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Showing 1–18 of 18 results

Advanced filters: Author: Silke Beck Clear advanced filters

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Heterozygous mutateons in the caspase-8 cleavage site of RIPK1 cause a range of autoinflammatory symptoms in humans, and caspase-8 cleavage of RIPK1 in a mouse model limits TNF-induced cell death and inflammation.

Najoua Lalaoui
Steven E. Boyden
John Silke
Research11 Dec 2019
Nature

Volume: 577, P: 103-108
Epidemiology and treatment of malignant ovarian germ cell and sex cord stromal tumors in germany: a population-based cancer registry study from 2016 – 2021

Dennis Jung
Sinaida Branscheidt
Annette Hasenburg
ResearchOpen Access18 Dec 2025
Scientific Reports

Volume: 15, P: 1-7
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Here, the authors describe biallelic loss-of-function variants in human SHARPIN in individuals with autoinflammation and immunodeficiency, termed sharpenia. They also successfully treat one of these individuals with TNF inhibitors.

Hirotsugu Oda
Kalpana Manthiram
Daniel L. Kastner
Research12 Apr 2024
Nature Immunology

Volume: 25, P: 764-777
Catastrophic disruption of asteroid 2023 CX1 and implications for planetary defence

2023 CX1 is the only L-chondrite-like asteroid analysed from space to ground. It catastrophically fragmented in the atmosphere, depositing 98% of its energy in one burst—an unusual, high-risk fragmentation mode with implications for planetary defence.

Auriane Egal
Denis Vida
Peter Jenniskens
Research17 Sept 2025
Nature Astronomy

Volume: 9, P: 1624-1637
The moderating role of diet and physical activity in insulin resistance and immunometabolic depression

Judith R. Gruber
Carmen Schiweck
Silke Matura
ResearchOpen Access23 Dec 2025
Scientific Reports

Volume: 15, P: 1-11
The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression

Carmen Schiweck
Mareike Aichholzer
Sharmili Edwin Thanarajah
ResearchOpen Access06 Dec 2025
Translational Psychiatry

Volume: 15, P: 1-14
Regulation of c-myc expression by Ras/Raf signalling

Eugen Kerkhoff
Roland Houben
Ulf R Rapp
Research23 Jan 1998
Oncogene

Volume: 16, P: 211-216
The IPCC and the politics of anticipation

In the emerging post-Paris climate governance regime, the role of scientific expertise is radically changing. The IPCC in particular may find itself in a new role, where projections of future climate function as a kind of regulatory science. This poses great challenges to conventional ideals of scientific neutrality.

Silke Beck
Martin Mahony
Comments & Opinion28 Apr 2017
Nature Climate Change

Volume: 7, P: 311-313
Next-generation sequencing in X-linked intellectual disability

Andreas Tzschach
Ute Grasshoff
Peter Bauer
Research04 Feb 2015
European Journal of Human Genetics

Volume: 23, P: 1513-1518
Renegotiating the global climate stabilization target

Climate policy has gained focus with the adoption of the 2 °C target, but action to avoid dangerous climate change has not occurred as expected. It is time to reconsider the target, and most importantly, the relationship between climate science and policy.

Oliver Geden
Silke Beck
Comments & Opinion27 Aug 2014
Nature Climate Change

Volume: 4, P: 747-748
The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis

Johanna M. Schwarzer
Inga Meyhoefer
Sara Piccin
ResearchOpen Access18 Aug 2022
Neuropsychopharmacology

Volume: 47, P: 2051-2060
Three institutional pathways to envision the future of the IPCC

The IPCC has been successful at building its scientific authority, but it will require institutional reform for staying relevant to new and changing political contexts. Exploring a range of alternative future pathways for the IPCC can help guide crucial decisions about redefining its purpose.

Shinichiro Asayama
Kari De Pryck
Mike Hulme
Comments & Opinion04 Sept 2023
Nature Climate Change

Volume: 13, P: 877-880
A Role for Decorin in the Structural Organization of Periodontal Ligament

Lari Häkkinen
Silke Strassburger
Hannu Larjava
Research01 Dec 2000
Laboratory Investigation

Volume: 80, P: 1869-1880
Empathic responses to unknown others are modulated by shared behavioural traits

Silke Anders
Christian Beck
Martin Lotze
ResearchOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors

Julia C. Kuehn
Patrick Metzger
Florian Scherer
ResearchOpen Access14 Aug 2024
npj Precision Oncology

Volume: 8, P: 1-11
Integrated colloidal quantum dot photodetectors with color-tunable plasmonic nanofocusing lenses

Silke L Diedenhofen
Dominik Kufer
Gerasimos Konstantatos
ResearchOpen Access16 Jan 2015
Light: Science & Applications

Volume: 4, P: e234
Glaucoma related Proteomic Alterations in Human Retina Samples

Sebastian Funke
Natarajan Perumal
Franz H. Grus
ResearchOpen Access18 Jul 2016
Scientific Reports

Volume: 6, P: 1-18
c-Myc and EBV–LMP1: two opposing regulators of the HLA class I antigen presentation machinery in epithelial cells

C S Tudor
C W Dawson
M Buettner
ResearchOpen Access15 May 2012
British Journal of Cancer

Volume: 106, P: 1980-1988