Nature Search

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

Hanshen Yang
Xiaozhen Zhang
Xueli Bai
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-19
An end-to-end fault interpretation method driven by visual foundation model with domain adaptation fine-tuning

Yun Liu
Fengyuan Zhang
Jizhou Tang
ResearchOpen Access24 Nov 2025
Scientific Reports

Volume: 15, P: 1-16
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis

Analysis of exome sequencing data identifies a burden of rare coding variants in 19 genes associated with bone mineral density. Integrated analyses show convergence of common- and rare-variant signals and highlight likely effector genes influencing osteoporosis risk.

Sirui Zhou
Olukayode A. Sosina
Luca A. Lotta
Research09 Aug 2023
Nature Genetics

Volume: 55, P: 1277-1287
Men resist men: streamer-consumer gender match for advertising the functional benefits of heterogeneously priced utilitarian products

Sirui Li
Ying Liu
Hui Fu
ResearchOpen Access01 May 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration

Activation of the stimulator of interferon genes (STING) can induce immunity in various cancer therapies, but delivery of STING agonists to tumours is challenging. Now a metal-based polymeric nanoparticle delivers STING agonists to tumours upon disruption of endothelial cells in tumour vasculature and targets tumour-associated macrophages, eliciting anti-tumour immune response in hard-to-treat cancer models.

Kaiting Yang
Wenbo Han
Ralph R. Weichselbaum
Research27 Oct 2022
Nature Nanotechnology

Volume: 17, P: 1322-1331
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

ALS-associated mutations in TDP-43 enhance its localization to mitochondria, and the inhibition of mitochondrial targeting reduces neuronal toxicity and alleviates motor phenotypes induced by TDP-43 expression in mice in vivo.

Wenzhang Wang
Luwen Wang
Xinglong Wang
Research27 Jun 2016
Nature Medicine

Volume: 22, P: 869-878
Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective

Jianjun Wang
Pei Yang
Decai Wang
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Contributions of distinct gold species to catalytic reactivity for carbon monoxide oxidation

Nanoscale supported gold clusters are common redox catalysts but in many cases the nature of the active sites remains unclear. Here, the authors use X-ray absorption to determine the contribution of single gold atoms, clusters and particles on the reactivity of room-temperature carbon monoxide oxidation.

Li-Wen Guo
Pei-Pei Du
Chun-Hua Yan
ResearchOpen Access16 Nov 2016
Nature Communications

Volume: 7, P: 1-8
Reversible formation of coordination bonds in Sn-based metal-organic frameworks for high-performance lithium storage

Tin-based alloying materials have been widely developed for lithium storage, but are limited by large volume variation. Herein, the authors created a new strategy of applying coordination chemistry to construct tin-based metal-organic frameworks which exhibited high-performance lithium storage property.

Jingwei Liu
Daixi Xie
Peng Cheng
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-10
Unique structure of active platinum-bismuth site for oxidation of carbon monoxide

The technological development requires the future advanced combustion engines be designed to operate at low temperature. Here, the authors show that partially oxide Pt-[O]_x-Bi interface catalyzes CO oxidation at ~ 50 °C via providing moderate CO adsorption and activating CO molecules with electron transformation.

Bing Nan
Qiang Fu
Rui Si
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-11
Association between sleep and ALS-FTSD: A Prospective Cohort Study based on 396,918 UK biobank participants

Tianmi Yang
Dejiang Pang
Huifang Shang
ResearchOpen Access04 Apr 2025
Translational Psychiatry

Volume: 15, P: 1-9
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease

Chunyu Wang
Fan Zhang
Xiongwei Zhu
ResearchOpen Access03 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Clinical characteristics and outcomes of COVID-19 in pediatric patients with rheumatic diseases

Yating Wang
Shu Su
Xuemei Tang
ResearchOpen Access07 Oct 2024
Pediatric Research

Volume: 97, P: 2045-2055

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