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Phellodendron amurense is a Tertiary relict species with significant ecological and medicinal value. Here, the authors report its genome assembly and reveal the involvement of CNMT gene family is berberine biosynthesis.

Native mass spectrometry can be combined with lipidomic experiments to determine the structural and functional lipids of receptor and transporter assemblies. This protocol describes how to use initial native mass spectrometry results to guide experimental design.

Spatially resolving cationic (edge) and anionic (center) vacancies in Bi₂WO₆ nanosheets generates a defect dipole. This architecture optimizes the internal electric field and surface kinetics, leading to superior photocatalytic activity.

Interferons are a key part of antiviral immunity. Here, the authors identify prefoldin and UBA3 as previously unrecognized regulators of interferon responses. Rotavirus VP3 effectively subverts this pathway to promote viral replication and represents a target for antiviral development.

Quantum state engineering necessitates transfer between quantum states. Here the authors demonstrate coherent population transfer between un- or weakly-coupled states of solid state systems, superconducting Xmon and phase qutrits, using stimulated Raman adiabatic passage and microwave driving.

Magnetic semiconductors provide control of spin states in addition to charge states realized in conventional semiconductors, yet currently limited to weak magnetism at low temperature. Liuet al. introduce oxygen into a ferromagnetic metallic glass, resulting in a Curie temperature above 600 K.

Starble, Sun, and colleagues identify an epigenetic priming mechanism that promotes oncogene amplification in acquired resistance to tyrosine kinase inhibitors and establishes a role of METTL7A in this process.

In this work, authors present a supramolecular fluorescent sensor array that enables the accurate discrimination of intracellular bacteria, also demonstrating that this can be modified as a host-guest drug delivery system to combat these bacteria.

This study uses deep learning and gaze-tracking to track pathologists' work and learn how they review tissue images. This “learned expertise” was applied to guide artificial intelligence models, such as weakly supervised learning and reinforcement learning, to achieve accurate diagnosis of Whole Slide Images.

The amino acid transporter complex LAT1-4F2hc is considered a major drug target for many cancers. Here, the authors apply native mass spectrometry-based approaches to decode a complete LAT1-4F2hc assembly. To do this, they connect post-translational modification and endogenous phospholipid binding to super-dimerization, function and localisation of LAT1-4F2hc.

Removal of damaged mitochondria maintains cellular homeostasis and regulates inflammation. Qian and colleagues describe a mechanism by which intracellular bacteria such as Listeria can elicit mitophagy to enable their survival.

The molecular classification and tumour microenvironment in intrahepatic cholangiocarcinoma (iCCA) need further characterisation. Here, the authors perform single cell RNA-sequencing from 14 pairs of iCCA tumours and non-tumour liver tissues and propose S100P and SPP1 as markers for patient classification.

The authors showcase a photonic tensor core in TFLN platform that achieves a computational speed of 120 GOPS for neural networks, with capabilities of in-situ training that support exciting prospects of negative number multiplication. The tensor core can efficiently process 112  × 112-pixel images, potentially scaling up AI tasks and offering nanosecond latency without needing a digital processor.

The de novo synthesis of enzyme-like active sites remains a challenge, due to the difficulties in imitating the spatial arrangement of the functional groups. Here, the authors report the construction of a supramolecular mimetic enzyme possessing catechol oxidase-like copper-cluster active sites.

Generic synthesis of metal-N4 moieties is interesting but challenging. Here the authors report an interfacial-fixing strategy to prepare neighboring metal-N4 sites, such as Fe2-N6, for oxygen reduction reaction.

Jiang et al. document an abundance of neutrophil-derived migrasomes in the blood of mice and humans and show that migrasomes are enriched in coagulation factors, accumulate at sites of injury and trigger platelet activation and clot formation.

We achieve the first deterministic coupling of a topological corner state with a single quantum dot, observing Purcell enhancement and polarized single-photon emission. This extends the effect of higher-order topological phase into the quantum realm.

Wide-spread outbreaks of pathogens require high intensity testing to manage. Here, the authors present C19-SPAR-Seq, a scalable and automated platform to analyse tens of thousands of SARS-CoV-2 patient samples in a single run.

Siyuan Zheng, Roel Verhaak and colleagues report an analysis of telomere lengths and somatic alterations in telomere-related pathways across 31 cancer types. Their study provides an overview of the molecular mechanisms driving TERT expression and activation of the ALT pathway, and identifies a subset of tumors with neither detectable TERT expression nor somatic alterations in ATRX or DAXX.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Combined analysis of Chang’e-3 in situ measurements and Chang’e-5 laboratory samples, with an updated chronology from Chang’e-5 data, reconstructed the relation between age and composition of young lunar mare basalts. Results indicate persistent volcanism 2 Gyr ago, indicative of the presence of a heat source at the time.

The slow research cycle of material design, characterization and testing has hampered the development of new cathode materials for solid oxide fuel cells. Here the authors develop a machine-learning approach, which makes use of ionic Lewis acid strength as a descriptor, for discovery of improved perovskite oxide cathodes.

Tumour cells can communicate with cells from distant organs through extracellular vesicles. Here the authors show that breast cancer cells derived exosomal miR-204-5p induce leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia.

Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to promote anti-tumour immunity and allo-responses.

In this Resource article, the authors integrate genomic, bioinformatic and flow cytometric data from human bone marrow to provide an atlas of hematopoietic progenitor cell states in health and disease.

Critical energy minerals face persistent shortages. Deep-sea mining offers a potential supplement but raises environmental, technical, and governance concerns. Drawing on interdisciplinary literature and policy review, this comment analyzes the resource potential and commercialization challenges of deep-sea mining. We propose five priorities: building sustainable consensus, advancing green technologies, establishing commercialization safeguards, strengthening global monitoring, and enhancing the International Seabed Authority’s capacity to foster cooperative global governance.

The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional target of YAP/TAZ, thus providing a feed forward loop to promote tumorigenesis.

Through integration of lipidomic and proteomic analyses of exosomes from patients with COVID-19, Lam et al. find that exosomes from different stages of infection have distinct compositions and can evoke distinct responses in recipient cells.

The Microbiome Quality Control project consortium reports outcomes of a baseline study (MBQC) that will guide future improvements in reproducibility of microbiome analyses.

Isotopic enrichment in hexagonal boron nitride is shown to enhance the propagation properties of phonon polaritons, achieving a threefold enhancement in their lifetime.