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Layered double hydroxides are promising candidates for electrocatalytic oxygen evolution reaction yet their catalytic stability needs to be further improved. Here, the authors use trimesic acid anchoring to stabilize nickel-iron layered hydroxides for water oxidation with enhanced stability.

Fluorinated elastomers as photoresists in the fabrication of soft neural probes are used to enhance the spatiotemporal recording capability at single-neuron resolution within the central nervous system of rodents.

Phellodendron amurense is a Tertiary relict species with significant ecological and medicinal value. Here, the authors report its genome assembly and reveal the involvement of CNMT gene family is berberine biosynthesis.

The authors developed flexible, unfolded mesh electronics for implantation in multiple brain regions of mice. The probes show minimal immune response and electrode drift, enabling stable recording of single-unit action potentials from the same neurons during the adult life of animals.

Single-photon sources with a single-photon efficiency of 0.60, a single-photon purity of 0.975 and an indistinguishability of 0.975 are demonstrated. This is achieved by fabricating elliptical resonators around site-registered quantum dots.

Quantum state engineering necessitates transfer between quantum states. Here the authors demonstrate coherent population transfer between un- or weakly-coupled states of solid state systems, superconducting Xmon and phase qutrits, using stimulated Raman adiabatic passage and microwave driving.

Introducing spin–orbit coupling by substrate proximity effect leads to an enhancement of superconducting phases in rhombohedral trilayer graphene.

Light-driven micromotors can convert energy to motion in sub-millimeter dimensions. Here, the authors extend this concept and introduce reconfigurable micromachines with multiple components, driven by optoelectronic tweezers, and demonstrate new functionalities.

Ying, Paulson and collagues have developed an open-source framework, Biolearn, to harmonize and systematically evaluate 39 aging biomarkers across diverse populations, enabling standardized validation and facilitating development of robust aging biomarkers.

The electrical response of the eye to optical stimulus is important in disease diagnosis but current electrodes used have limitations. Here, the authors report on the development of soft transparent graphene-based contact lens electrodes for electroretinogram recording and test the device in vivo.

Cost-efficient electrolytes are important for the development of multivalent metal batteries, but expensive precursors and complex synthesis hinder progress. The authors present a cation replacement method for low-cost, high-reversibility magnesium and calcium electrolytes, advancing high-energy-density multivalent metal batteries.

A combination of exciton sensing and optical pump–probe spectroscopy is used to investigate the dynamics of isospin orders in MATBG with WSe₂ substrate across the entire flat band, achieving sub-picosecond resolution.

This study comprehensively benchmarks 18 state-of-the-art methods for cellular deconvolution of spatial transcriptomics and provide decision-tree-style guidelines and recommendations for method selection.

A study reports a dual quantum spin Hall insulator in monolayer TaIrTe₄, arising from the interplay of its single-particle topology and density-tuned electron correlations.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

A screen of nutrient-derived compounds identified trans-vaccenic acid as a promoter of effector T cell function, and functional assays demonstrate that this occurs via inactivation of GPR43 on T cells.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

Interaction between SETD2 and hnRNP L has previously been shown to be implicated in coupling gene transcription and mRNA processing. Here the authors elucidate the molecular basis of this functional interaction, showing that the RRM domain of hnRNP L possesses non-overlapping binding interfaces for engaging RNA and SETD2.

Spatial transcriptomics (ST) technologies detect transcript distribution in space. Here, authors present a deep learning based method SPACEL for cell type deconvolution, spatial domain identification and 3D alignment, showcasing it as a valuable toolkit for ST data analysis

De Ravin et al. report an unplanned interim analysis of a secondary safety outcome for an ongoing clinical trial on lentiviral gene therapy for the treatment of X-linked Severe Combined Immunodeficiency (NCT01306019). Vector induced alternative splicing events are identified that cause aberrant fusion transcripts, leading to clonal dominance in a single patient and clonal expansion in others. This can be mitigated by the removal of the lentivector cryptic splice acceptor.

The fate of proteins in cells is determined by not only synthesis but also degradation. Here Chen et al. show that degradation of the plant blue light receptor CRY2 is determined by two distinct E3 ubiquitin ligases, Cul4^COP1/SPAs and Cul3^LRBs, regulating the function of CRY2 under different light conditions.

Deterministic single-photon sources are a key building block for photonic quantum technologies. Stimulated emission now helps tailoring spontaneous emission from a ladder-type three-level system in a single epitaxial quantum dot for bright polarized sources with a high photon purity and indistinguishability.

Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic activity in clear cell renal carcinomas.

Dai and colleagues reveal that proteotoxic stress causes JNK-mediated disintegration of the mTORC1 complexes, whereas heat shock factor 1 (HSF1) counteracts this response to promote stress resistance and growth.

Cis-trans lactam amide rotation is a fundamental process and its understanding might aid molecular design. Here, the authors report the synthesis and study of bicyclic lactams which undergo spin through 360 degrees as in open-chain amides, due to the occurrence of nitrogen pyramidalization.

We demonstrate a high-performance single-photon source based on a monolithic FP microcavity, and the thin-film microcavity structure facilitates effective strain transduction.

This Perspective explores the use of flexible electronics in the development of brain–computer interfaces, considering their potential impact on neuroscience, neuroprosthetic control, bioelectronic medicine, and brain and machine intelligence integration.

Using super-resolution imaging to directly observe the three-dimensional organization of Drosophila chromatin at a scale spanning sizes from individual genes to entire gene regulatory domains, the authors find that transcriptionally active, inactive and Polycomb-repressed chromatin states each have a distinct spatial organisation.

Chromatin interaction profiling reveals how enhancer-promoter interactions regulate Ucp1 in brown adipose tissue, highlighting key enhancers and transcriptional mechanisms driving thermogenesis and mitochondrial function under cold conditions.

Data harmonization of MRI scans can improve consistency when analysing MRI data from different instruments in different locations. Liu and Yap report an efficient deep neural network method to disentangle site-specific information from site-invariant anatomical information in MRI images. The approach allows data in a wide range of existing studies, conducted via different imaging protocols, to be harmonized.

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.