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Showing 1–50 of 51 results

Advanced filters: Author: Sreenivas V Clear advanced filters

Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiae

Mammalian recombination activating genes RAG1 and RAG2 are essential for the production and diversification of antibodies and T-cell receptors via V(D)J recombination in lymphocytes but are absent in simpler eukaryotes such as the yeast Saccharomyces cerevisiae. Here the authors integrate mouse RAG1/2 in S. cerevisiae and demonstrate the ability to create combinatorial diversity starting from a single genetic locus in vivo.

Andrew P. Cazier
Jaewoo Son
John Blazeck
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field

As leishmaniasis control programs and new vaccines are advancing, it is necessary to re-introduce the leishmanin skin test to monitor transmission and immunity. This study describes the generation and validation of a new leishmanin skin test antigen for future re-introduction into endemic countries.

Ranadhir Dey
Jalal Alshaweesh
Greg Matlashewski
ResearchOpen Access02 Nov 2023
Nature Communications

Volume: 14, P: 1-11
Sustainable synthesis and characterization of Zn–Al doped nanocomposites for removal of brilliant blue dye: optimization using a response surface methodology

Sreenivas Matla
Gnanakumari Talathoti
Meena Vangalapati
ResearchOpen Access21 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
An L-shaped flexible neural implant for chronic ECoG signal acquisition in M2 region of control and Parkinsonian rat models

Sreenivas Bhaskara
K. V. Shabari Girishan
Hardik Jeetendra Pandya
ResearchOpen Access11 Nov 2025
Scientific Reports

Volume: 15, P: 1-14
A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

Here, the authors engineer an attenuated knock-out Leishmania (LmCen^−/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen^−/− is antibiotic resistant marker free, it is a candidate for clinical development.

Wen-Wei Zhang
Subir Karmakar
Hira L. Nakhasi
ResearchOpen Access10 Jul 2020
Nature Communications

Volume: 11, P: 1-14
The effect of intrinsic crumpling on the mechanics of free-standing graphene

Free-standing graphene is inherently crumpled in the out-of-plane direction due to dynamic flexural phonons and static wrinkling. Here, the authors use optical interferometry as a delicate probe to investigate the consequences of this crumpling on the effective mechanical constants of graphene.

Ryan J.T. Nicholl
Hiram J. Conley
Kirill I. Bolotin
ResearchOpen Access06 Nov 2015
Nature Communications

Volume: 6, P: 1-7
MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57^Kip2 targeting

SKP2 is an oncogenic E3-ubiquitin ligase. Here the authors show that SKP2 is epigenetically regulated by the muscle lineage transcription factor MYOD, supports tumorigenesis in the Fusion Negative (FN) subtype of rhabdomyosarcoma (RMS) and impairs differentiation promoting degradation of p57^Kip2.

Silvia Pomella
Matteo Cassandri
Rossella Rota
ResearchOpen Access15 Dec 2023
Nature Communications

Volume: 14, P: 1-23
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super enhancers, binds to MYOD target enhancers, and arrests differentiation.

Silvia Pomella
Prethish Sreenivas
Myron S. Ignatius
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Flipping of alkylated DNA damage bridges base and nucleotide excision repair

A class of enzymes known as alkyltransferase-like proteins (ATLs) can protect against alkylation damage to DNA. To gain insight into how this occurs, the structure of a yeast ATL has been solved in the presence and absence of damaged DNA, revealing that ATL flips the alkylated base out of the DNA helix, leaving the lesion to be acted on by proteins of the nucleotide excision repair pathway.

Julie L. Tubbs
Vitaly Latypov
John A. Tainer
Research11 Jun 2009
Nature

Volume: 459, P: 808-813
A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.

Pavithra L. Chavali
Gayathri Chandrasekaran
Fanni Gergely
ResearchOpen Access18 Mar 2016
Nature Communications

Volume: 7, P: 1-16
Sequence composition of disordered regions fine-tunes protein half-life

The proteasome initiates protein degradation at disordered regions within substrates. The proteasomal sequence preferences for the amino acid composition of these regions identified here affect protein half-life and explain unusual stability trends.

Susan Fishbain
Tomonao Inobe
Andreas Matouschek
Research02 Feb 2015
Nature Structural & Molecular Biology

Volume: 22, P: 214-221
Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins

Computational analyses of the yeast proteome and experimental work show that homorepeats facilitate protein-protein interactions and rapid protein divergence. To balance their propensity to aggregate, homorepeats are preferentially retained in proteins that are stringently regulated.

Sreenivas Chavali
Pavithra L Chavali
M Madan Babu
Research14 Aug 2017
Nature Structural & Molecular Biology

Volume: 24, P: 765-777
Harnessing Ni–V stabilized Ag/AgCl nanofoam for multifaceted reaction

Manash J. Baruah
Rajarshi Bayan
Mukesh Sharma
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Anushikha Thakur
Rekha Nagpal
Ramakrishnan Melarkode Subbaraman
Amendments and CorrectionsOpen Access30 Aug 2021
Scientific Reports

Volume: 11, P: 1
Does ultrasound guidance for peripherally inserted central catheter (PICC) insertion reduce the incidence of tip malposition? – a randomized trial

Tejopratap Oleti
M. Jeeva Sankar
Vinod K. Paul
Research22 Oct 2018
Journal of Perinatology

Volume: 39, P: 95-101
Deletion of MIF gene from live attenuated LdCen^−/− parasites enhances protective CD4⁺ T cell immunity

Jacqueline Araújo Fiuza
Sreenivas Gannavaram
Rodrigo Correa-Oliveira
ResearchOpen Access05 May 2023
Scientific Reports

Volume: 13, P: 1-18
Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study

Donghao Zhou
Bo Xi
Sreenivas P. Veeranki
ResearchOpen Access20 Jun 2018
Scientific Reports

Volume: 8, P: 1-7
Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Anushikha Thakur
Rekha Nagpal
Ramakrishnan Melarkode Subbaraman
ResearchOpen Access24 Jun 2021
Scientific Reports

Volume: 11, P: 1-21
Laccase production by Coriolopsis caperata RCK2011: Optimization under solid state fermentation by Taguchi DOE methodology

Preeti Nandal
Sreenivas Rao Ravella
Ramesh Chander Kuhad
ResearchOpen Access06 Mar 2013
Scientific Reports

Volume: 3, P: 1-7
Downregulation of IRF7-mediated type-I interferon response by LmCen^–/– parasites is necessary for protective immunity

Telly Sepahpour
Jalal Alshaweesh
Sreenivas Gannavaram
ResearchOpen Access19 Dec 2024
npj Vaccines

Volume: 9, P: 1-12
Using a Taguchi DOE to investigate factors and interactions affecting germination in Miscanthus sinensis

Danny Awty-Carroll
Sreenivas Ravella
Paul Robson
ResearchOpen Access31 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
Changes in physical characteristics of extreme rainfall events during the Indian summer monsoon based on downscaled and bias-corrected CMIP6 models

Stella Jes Varghese
Sreenivas Pentakota
Karumuri Ashok
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer

Sreenivas Adurthi
Mahesh M. Kumar
R. S. Jayshree
ResearchOpen Access11 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Spatiotemporal atmospheric in-situ carbon dioxide data over the Indian sites-data perspective

Mahesh Pathakoti
Mahalakshmi D.V.
Vinay Kumar Dadhwal
ResearchOpen Access16 Apr 2024
Scientific Data

Volume: 11, P: 1-9
Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization

Sreenivas Gannavaram
John Torcivia
Hira L. Nakhasi
ResearchOpen Access05 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
LmCen^−/− based vaccine is protective against canine visceral leishmaniasis following three natural exposures in Tunisia

Thouraya Boussoffara
Imen Labidi
Elyes Zhioua
ResearchOpen Access14 Feb 2025
npj Vaccines

Volume: 10, P: 1-11
Impact of simple interventions on neonatal mortality in a low-resource teaching hospital in India

R Agarwal
K Agarwal
S Seetaraman
Research14 Dec 2006
Journal of Perinatology

Volume: 27, P: 44-49
Effect of heterologous intranasal iNCOVACC^® vaccination as a booster to two-dose intramuscular Covid-19 vaccination series: a randomized phase 3 clinical trial

Venkateshwar et al., explored the effect of Heterologous intranasal iNCOVACC® vaccination as a booster to two-dose intramuscular Covid-19 vaccinations (either by Covishield or Covaxin) in a controlled, randomised, open-label phase 3 clinical trial. This study also aimed to compare these results with homologous booster vaccinations by Covishield or Covaxin.

Venkateshwar Rao Akula
Amit Suresh Bhate
Sai. D Prasad
ResearchOpen Access23 Apr 2025
Communications Medicine

Volume: 5, P: 1-12
Manufacturing and preclinical toxicity of GLP grade gene deleted attenuated Leishmania donovani parasite vaccine

Kumar Avishek
Mirza A. Beg
Angamuthu Selvapandiyan
ResearchOpen Access25 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Phase III Pivotal comparative clinical trial of intranasal (iNCOVACC) and intramuscular COVID 19 vaccine (Covaxin^®)

Chandramani Singh
Savita Verma
Krishna Mohan Vadrevu
ResearchOpen Access18 Aug 2023
npj Vaccines

Volume: 8, P: 1-9
Screening COVID-19 by Swaasa AI platform using cough sounds: a cross-sectional study

Padmalatha Pentakota
Gowrisree Rudraraju
Vardhan Avasarala
ResearchOpen Access25 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
Body composition of term healthy Indian newborns

V Jain
A V Kurpad
V K Paul
Research16 Sept 2015
European Journal of Clinical Nutrition

Volume: 70, P: 488-493
Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

Polyphenols are widely studied as potential drugs for Alzheimer’s disease, but their development is limited by poor bioavailability. Here polyphenolic analogues of the Alzheimer's disease drug rivastigmine are shown to inhibit both cholinesterase and amyloid beta fibrillation in vitro and in vivo in a C. elegans model, providing a potentially general route for the development of polyphenol-based drugs.

Satish N. Dighe
Eugenio De la Mora
Benjamin P. Ross
ResearchOpen Access22 Mar 2019
Communications Chemistry

Volume: 2, P: 1-14
PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling

Here, the authors demonstrate that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits the retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. This study shows that PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.

Mamta Verma
Mohd. Imran K. Khan
Arunkumar Dhayalan
ResearchOpen Access25 Jan 2021
Communications Biology

Volume: 4, P: 1-15
Magnetization–structure–composition phase diagram mapping in Co-Fe-Ni alloys using diffusion multiples and scanning Hall probe microscopy

Girfan Shamsutdinov
Peng Zhao
Boris Nadgorny
ResearchOpen Access04 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway

Trayambak Basak
Vinay Singh Tanwar
Shantanu Sengupta
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Association of variants in genes involved in pancreatic β-cell development and function with type 2 diabetes in North Indians

Sreenivas Chavali
Anubha Mahajan
Dwaipayan Bharadwaj
Research04 Aug 2011
Journal of Human Genetics

Volume: 56, P: 695-700
Presence of 25(OH)D deficiency and its effect on vitamin D receptor mRNA expression

R Goswami
A M Mondal
V Sreenivas
Research09 Apr 2008
European Journal of Clinical Nutrition

Volume: 63, P: 446-449
Effect of vitamin D supplementation on cathelicidin, IFN-γ, IL-4 and Th1/Th2 transcription factors in young healthy females

M Das
N Tomar
R Goswami
Research08 Jan 2014
European Journal of Clinical Nutrition

Volume: 68, P: 338-343
Heparin for prolonging peripheral intravenous catheter use in neonates: a randomized controlled trial

A Upadhyay
K K Verma
V Sreenivas
Research04 Dec 2014
Journal of Perinatology

Volume: 35, P: 274-277
Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

Kumar Avishek
Himanshu Kaushal
Poonam Salotra
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Amino acid homorepeats in proteins

Although amino acid repeats have been linked to a diverse range of diseases, they are prevalent in the human proteome. This Review describes their physiological importance, the factors that influence their conformations and therapeutic strategies to treat repeat-related diseases.

Sreenivas Chavali
Anjali K. Singh
M. Madan Babu
Reviews21 Jul 2020
Nature Reviews Chemistry

Volume: 4, P: 420-434
Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

Subir Karmakar
Greta Volpedo
Hira L. Nakhasi
ResearchOpen Access03 Dec 2022
npj Vaccines

Volume: 7, P: 1-9
Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen^−/−) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable protection against lethal VL that is transmitted naturally via bites of L. donovani-infected sand flies.

Subir Karmakar
Nevien Ismail
Hira L. Nakhasi
ResearchOpen Access30 Jul 2021
Communications Biology

Volume: 4, P: 1-14
Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis

Greta Volpedo
Thalia Pacheco-Fernandez
Abhay R. Satoskar
ResearchOpen Access02 Mar 2022
npj Vaccines

Volume: 7, P: 1-14
Goat lung surfactant for treatment of respiratory distress syndrome among preterm neonates: a multi-site randomized non-inferiority trial

Kajal Jain
Sushma Nangia
Ramesh Agarwal
ResearchOpen Access04 Sept 2019
Journal of Perinatology

Volume: 39, P: 3-12
Modelling the impact of effective private provider engagement on tuberculosis control in urban India

Nimalan Arinaminpathy
Sarang Deo
Puneet Dewan
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-9

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