Lymphocyte activation gene-3 (LAG3) is an immune checkpoint protein recently approved as a target for anti-melanoma therapy. Here, the authors solve the structure of mouse LAG3 bound to MHC-II to show that LAG3 blocks MHC-II/CD4 interactions, thereby implicating a potential mechanism of LAG3-mediated immune suppression.
- Qianqian Ming
- Daniel Antfolk
- Vincent C. Luca
