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The authors report on imaging developments of solid-density plasmas and the current filamentation instability by means of the LCLS-XFEL at SLAC. This offers insights on the instability in the solid density region, stimulating new modelling of laser-solid interactions.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Superradiance is usually driven by light-mediated couplings, leaving the role of direct emitter interactions unclear. Now, it is shown that dipole–dipole interactions in diamond spins drive self-induced pulsed and continuous superradiant masing.

This work introduces the kinetic selectivity achievable in nanoporous crystals into the field of chemical sensors, opening the door for selective VOC detection in health, safety, and environmental monitoring

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Phonon polaritons are promising for mid-infrared photonics but only longitudinal optical phonons are directly accessed by electrical currents. Here, the authors predict and experimentally confirm hybrid longitudinal-transverse excitations. This could lead to phonon polariton-based electrically pumped mid-infrared emitters.

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

Conductive domain walls of ferroelectric materials are considered for device applications demanding a fundamental understanding of their dynamics. Here, frequency-dependent decoupling of strains upon electric field cycling in BiFeO₃ is demonstrated to arise from conductive domain walls.

This work experimentally demonstrates that light-field spatial modulation can be harnessed to substantially increase the forces used to optically levitate nanoparticles in vacuum.

The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

Medulloblastomas (MBs) are highly heterogeneous paediatric brain tumours that remain challenging to treat. Here, the authors integrate proteomics, epigenomics, transcriptomics and post-translational modification analyses to find molecular subgroups and potential therapeutic targets in MB tumours.

Bruton tyrosine kinase (BTK) inhibitors can interrupt the crosstalk between follicular lymphoma FL cells and macrophages thereby inducing downregulation of pro-survival pathways in FL cells. Here this group reports a phase 2 single-arm trial evaluating the regimen of acalabrutinib with lenalidomide plus rituximab on twenty four patients with previously untreated FL.

Burned structures in wildfires release air pollutants not included in emissions inventories. Structure burning in wildland-urban interface fires emit hazardous compounds at levels exceeding anthropogenic sources in some US states.

Analyses of primary and relapse samples of embryonal tumours with multilayered rosettes provide insights into the molecular mechanisms that underlie the development and opportunities for the treatment of this deadly disease.

Designing effective dielectrics in a broad range of the spectrum is of huge interest. Here, the authors demonstrate how transparent effective dielectrics can be constructed from dense arrays of metallic nanoparticles and can result in being more transparent than real dielectrics renowned for their transparency.

Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.

In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of care in patients with phospho-mTOR activation.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This study characterizes the interaction between the clinical candidate anle138b and Aβ₄₀ fibrils in a lipid environment. The compound reduced fibril formation by approximately 75%, providing insights relevant to Alzheimer’s drug development.

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

Ependymoma is a tumor of the brain or spinal cord with the two most common and aggressive types mainly occurring in children. Here the authors employ 3D genomics and epigenomics to reveal targets for aggressive ependymoma tumors in children.

Voltage-modulated scanning probe microscopy may elucidate important processes at solid–liquid interfaces, but it is complicated by the presence of mobile ions. By incorporating force sensitivity into a multidimensional measurement approach, Collins et al.present a technique that overcomes these limitations.

Magneto-optical effects in magnets are commonly attributed to the interplay between exchange splitting and spin-orbit coupling. Here, Feng et al. report a topological magneto-optical effect in non-coplanar antiferromagnets due to finite scalar spin chirality, without any reference to exchange splitting or spin-orbit coupling.

Comparing the ground-state hyperfine structure of antihydrogen to that of hydrogen will provide insights into CPT symmetry in nature. Here the authors report the most precise in-beam measurement of this quantity for hydrogen to demonstrate the viability of ASACUSA’s setup to measure it in antihydrogen.

Warm dense copper, created by an X-ray free-electron laser, features a transition from reverse saturable absorption to saturable absorption. The results can be used to benchmark non-equilibrium models of electronic structure in warm dense matter.

Arrays of quantum dots can exhibit a variety of quantum properties, being sensitive to their spacing. Here, the authors fine tune interdot coupling using hexagonal molecular networks in which the dots are separated by single or double haloaromatic compounds, structurally identical but for a single atom.

Equivariant neural networks are state-of-the-art for machine learning-driven molecular dynamics (MD) simulations but have high computational cost. Here, the authors develop a Euclidean transformer that balances accuracy, stability, and speed, enabling stable long-timescale simulations of complex molecules

Dietary inulin fibre alters the composition and metabolism of gut microbiota, resulting in elevated levels of bile acids that subsequently trigger mucosal type 2 inflammation characterized by eosinophilia, with clinical implications for allergy and anti-helminth defence.

Combining advanced photonics with reconfigurable liquid crystalline self-assembled structures allows control of a liquid crystal’s microlaser emission by nanosecond optical pulses and the ability to switch off the laser emission from the liquid crystal using the resonant stimulated-emission depletion process, providing a design for a new class of photonic integrated devices.

Authors showcase 3D direct laser writing to fabricate optically interfaced mechanical resonators. The membrane-type structures are placed inside fiber Fabry-Perot cavities to realize a miniaturized optical cavity. Further, the optomechanical properties reveal the coupling mechanism and a significant tuning of the mechanical resonator frequency.

The iron–nickel alloy Invar has an extremely small coefficient of thermal expansion that has been difficult to explain theoretically. A study of Invar under pressure now suggests that there is a cancellation of phonon and spin contributions to expansion.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

An integrated structural biology approach uncovers the structural complexity of the intrinsically disordered region (IDR) within the TRPV4 ion channel. Multiple stimulatory and inhibitory elements were identified within the IDR that modulate channel activity in a lipid-dependent manner.

A new scheme for multicolour X-ray free-electron lasers at soft X-ray wavelengths is proposed. The scheme significantly improves two-colour pulse generation and makes possible the first demonstration of three-colour pulse generation.

Tunable polarization control and a two-colour X-ray pump–X-ray probe operating mode are demonstrated at the Linac Coherent Light Source (LCLS).

Researchers demonstrate systems in which optical solitons coexist and interact with topological solitonic structures localized in the molecular alignment field of a soft birefringent medium. The findings could lead to solitonic tractor beams and new light–matter self-patterning phenomena.

Characterizing surfaces by Raman spectroscopy is limited by the competition of surface and bulk Raman responses. Here the authors use nanoporous plasmonic membranes to enhance surface Raman signals while suppressing bulk contributions.

SARS-CoV-2 mutations associated with the escape from antibody-mediated neutralization have been widely reported. Here, in a patient with defective antibody responses, the authors find a potential association between SARS-CoV-2 mutations and CD8 T alterations to implicate possible contributions of CD8 T cells in evasion of SARS-CoV-2 from host immunity.

Phonon polariton quasi-bound states in the continuum realized in a dielectric metasurface patterned with a subwavelength lattice of elliptical holes in a commercially available free-standing, large-area 100-nm-thick silicon carbide membrane is demonstrated, attractive for applications in mid-infrared optics, such as molecular sensing and thermal radiation engineering.

Radke et al. found an interferon response in the brainstem nuclei of acute COVID-19 that, in addition to the inflammatory reaction, spreads throughout the vascular unit altering glial cells and resolves in late disease states in the absence of brain infection.

Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arterial hypertension identifies 3 subgroups (endophenotypes) that improve risk stratification and provide new molecular insights.

Genomic surveillance of SARS-CoV-2 can inform regional transmission dynamics and inform public health interventions. Here, the authors sequence ~200 samples from Rwanda, identify shifts in predominating strains from May 2020 to February 2021, and infer geographic origins.

Sanfeliu-Cerdán et al. show that an SH3-domain-induced rigidity transition of MEC-2/stomatin condensates enables mechanotranduction of external forces in C. elegans touch receptor neurons.

Knowledge of the electron-gas dynamics in nanometric hot spots is of importance for hot-carrier technologies. Here Lozan et al. present a theoretical and experimental analysis of the spatio-temporal dynamics of hot electrons in a nano-focusing surface-plasmon polariton taper.

Whispering-gallery-mode resonators made of nematic liquid-crystal droplets offer a wavelength tunability approximately two orders of magnitude larger than that of conventional solid-state microresonators.

Advances in electron microscopy are enabling ever smaller features to be probed, with the measurement of atomic electric fields standing as a major challenge. Towards that aim, Müller et al.present a simplified theoretical approach for enhancing the resolution in differential phase contrast microscopy.

Here the authors perform the reconstruction and analysis of pathological ALys amyloid fibrils extracted from fat tissue from a patient carrying the D87G variant. They reveal an intact amyloid fibril with no evidence of proteolysis and four intact disulphide bonds.

Atypical teratoid/rhabdoid brain tumours are characterized by loss of chromatin remodelling complex member SMARCB1. Here, using a genetic screen in Drosophila, the authors identify a number of genes involved in the detrimental effects of SMARCB1 deficiency.