Nature Search

High-throughput oncogene mutation profiling in human cancer

Roman K Thomas
Alissa C Baker
Levi A Garraway
Research11 Feb 2007
Nature Genetics

Volume: 39, P: 347-351
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

Yingchang Lu
Felix R. Day
Ruth J. F. Loos
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder

Stephan Heinzel
Christian Kaufmann
Norbert Kathmann
ResearchOpen Access20 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-7
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

The role of circular RNAs (circRNAs) in modulating gene expression in cancer remains to be investigated. Here, the authors perform whole transcriptome sequencing in 104 primary neuroblastomas and reveal the involvement of MYCN in regulating circRNAs.

Steffen Fuchs
Clara Danßmann
Johannes H. Schulte
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.

Franziska Rudolph
Claudia Fink
Michael Gotthardt
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-10
Epitaxial growth of silicon nanowires using an aluminium catalyst

Yewu Wang
Volker Schmidt
Ulrich Gösele
Research26 Nov 2006
Nature Nanotechnology

Volume: 1, P: 186-189
Investigations on the morpho-anatomy and histochemistry of the European mistletoe: Viscum album L. subsp. album

Valter Paes de Almeida
Irailson Thierry Monchak
Jane Manfron
ResearchOpen Access21 Mar 2023
Scientific Reports

Volume: 13, P: 1-13
Melanoma genome sequencing reveals frequent PREX2 mutations

Whole-genome sequencing of 25 metastatic melanomas and matched germline DNA in humans reveals that the highest mutation load is associated with chronic sun exposure, and that the PREX2 gene is mutated in approximately 14 per cent of cases

Michael F. Berger
Eran Hodis
Levi A. Garraway
ResearchOpen Access09 May 2012
Nature

Volume: 485, P: 502-506
A candidate NAD⁺ transporter in an intracellular bacterial symbiont related to Chlamydiae

Ilka Haferkamp
Stephan Schmitz-Esser
H. Ekkehard Neuhaus
Research02 Dec 2004
Nature

Volume: 432, P: 622-625
Involvement of chemokine receptors in breast cancer metastasis

Anja Müller
Bernhard Homey
Albert Zlotnik
Research01 Mar 2001
Nature

Volume: 410, P: 50-56
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

S63845 specifically inhibits MCL1 and induces tumour cell death in vitro and in vivo in diverse cancer-derived cell lines with an acceptable safety margin.

András Kotschy
Zoltán Szlavik
Olivier Geneste
Research19 Oct 2016
Nature

Volume: 538, P: 477-482
Arthropod decline in grasslands and forests is associated with landscape-level drivers

Analyses of a dataset of arthropod biomass, abundance and diversity in grassland and forest habitats in Germany for the period 2008–2017 reveal that drivers of arthropod declines act at the landscape level.

Sebastian Seibold
Martin M. Gossner
Wolfgang W. Weisser
Research30 Oct 2019
Nature

Volume: 574, P: 671-674
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway

A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes.

Lorenz H Lehmann
Zegeye H Jebessa
Johannes Backs
Research11 Dec 2017
Nature Medicine

Volume: 24, P: 62-72
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Julien Bryois
Nathan G. Skene
Patrick F. Sullivan
Research27 Apr 2020
Nature Genetics

Volume: 52, P: 482-493
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.

Miles W. Carroll
David A. Matthews
Stephan Günther
ResearchOpen Access17 Jun 2015
Nature

Volume: 524, P: 97-101
P-block single-metal-site tin/nitrogen-doped carbon fuel cell cathode catalyst for oxygen reduction reaction

For oxygen reduction and hydrogen oxidation reactions, proton-exchange membrane fuel cells typically rely on precious-metal-based catalysts. A p-block single-metal-site tin/nitrogen-doped carbon is shown to exhibit promising electrocatalytic and fuel cell performance.

Fang Luo
Aaron Roy
Peter Strasser
Research13 Jul 2020
Nature Materials

Volume: 19, P: 1215-1223
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Levi A. Garraway
Hans R. Widlund
William R. Sellers
Research07 Jul 2005
Nature

Volume: 436, P: 117-122
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Genome-wide analyses identify eight independent loci associated with anorexia nervosa. Genetic correlations implicate both psychiatric and metabolic components in the etiology of this disorder, even after adjusting for the effects of common variants associated with body mass index.

Hunna J. Watson
Zeynep Yilmaz
Cynthia M. Bulik
Research15 Jul 2019
Nature Genetics

Volume: 51, P: 1207-1214
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.

Jesus Cosin-Roger
Simona Simmen
Pedro A. Ruiz
ResearchOpen Access24 Jul 2017
Nature Communications

Volume: 8, P: 1-13
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Tau plasma levels in subjective cognitive decline: Results from the DELCODE study

Stephan Müller
Oliver Preische
Christoph Laske
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

In an unanticipated cross-talk between the steroid and insulin endocrine systems, the neuroactive steroid pregnenolone sulphate is found to activate the TRPM3 channel, leading to enhanced insulin secretion from pancreatic islets.

Thomas F.J. Wagner
Sabine Loch
Johannes Oberwinkler
Research02 Nov 2008
Nature Cell Biology

Volume: 10, P: 1421-1430
Perceptual discrimination of action formidableness and friendliness and the impact of autistic traits

Alessia M. Vlasceanu
Stephan de la Rosa
Nick E. Barraclough
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-14
Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons

The role of actin-based motors and the mode of endoplasmic reticulum (ER) transport into spines had remained unclear. Myosin-Va is now shown to act as a point-to-point ER transporter into dendritic spines.

Wolfgang Wagner
Stephan D. Brenowitz
John A. Hammer III
Research12 Dec 2010
Nature Cell Biology

Volume: 13, P: 40-48
Cancer cachexia: multilevel metabolic dysfunction

In this Review, the authors highlight cancer cachexia as a complex and multifactorial disorder, and discuss the underlying host-driven and tumour-driven metabolic changes, therapeutic opportunities and the pertinent challenges in the treatment of cancer cachexia.

Mauricio Berriel Diaz
Maria Rohm
Stephan Herzig
Reviews22 Nov 2024
Nature Metabolism

Volume: 6, P: 2222-2245
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.

Hyun Ji Noh
Ruqi Tang
Kerstin Lindblad-Toh
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Graphene ribbons with suspended masses as transducers in ultra-small nanoelectromechanical accelerometers

Suspended double-layer graphene ribbons with attached silicon proof masses can be used to create transducers for nanoelectromechanical system accelerometers that occupy at least two orders of magnitude smaller die area than conventional state-of-the-art silicon accelerometers.

Xuge Fan
Fredrik Forsberg
Frank Niklaus
Research02 Sept 2019
Nature Electronics

Volume: 2, P: 394-404
Self-supervised MRI denoising: leveraging Stein’s unbiased risk estimator and spatially resolved noise maps

Laura Pfaff
Julian Hossbach
Andreas Maier
ResearchOpen Access19 Dec 2023
Scientific Reports

Volume: 13, P: 1-13
Conditioned up and down modulations of short latency gamma band oscillations in visual cortex during fear learning in humans

Alejandro Santos-Mayo
Javier de Echegaray
Stephan Moratti
ResearchOpen Access16 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Author Correction: The landscape of genomic alterations across childhood cancers

Susanne N. Gröbner
Barbara C. Worst
Stephanie Sungalee
Amendments and Corrections06 Jun 2018
Nature

Volume: 559, P: E10
Release of volatiles from a possible cryovolcano from near-infrared imaging of Titan

C. Sotin
R. Jaumann
C. K. Scholz
Research09 Jun 2005
Nature

Volume: 435, P: 786-789
Author Correction: A MHz-repetition-rate hard X-ray free-electron laser driven by a superconducting linear accelerator

W. Decking
S. Abeghyan
D. Zybin
Amendments and Corrections27 Jul 2020
Nature Photonics

Volume: 14, P: 650
Intercellular adhesion molecule-1 protects against adipose tissue inflammation and insulin resistance but promotes liver disease activity in western-diet fed mice

Sreepradha Eswaran
Laura Gebert
Angela Schippers
ResearchOpen Access17 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Electric fish measure distance in the dark

Gerhard von der Emde
Stephan Schwarz
Kirsty Grant
Research29 Oct 1998
Nature

Volume: 395, P: 890-894
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Fecher et al. devise an approach to isolate cell-type-specific mitochondria from the mouse CNS. They demonstrate proteomic diversity of cerebellar mitochondria covering bioenergetics, calcium handling and organelle contact sites.

Caroline Fecher
Laura Trovò
Thomas Misgeld
Research09 Sept 2019
Nature Neuroscience

Volume: 22, P: 1731-1742
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer.

Peer Aramillo Irizar
Sascha Schäuble
Christoph Kaleta
ResearchOpen Access30 Jan 2018
Nature Communications

Volume: 9, P: 1-11
Genome-wide, large-scale production of mutant mice by ENU mutagenesis

Martin Hrabé de Angelis
Heinrich Flaswinkel
Rudi Balling
Research01 Aug 2000
Nature Genetics

Volume: 25, P: 444-447
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa

Zheng-An Lu
Alexander Ploner
Sarah E. Bergen
ResearchOpen Access23 Sept 2025
Molecular Psychiatry

P: 1-10
Punctuated equilibrium comes of age

Stephan jay Gould
Niles Eldredge
Reviews18 Nov 1993
Nature

Volume: 366, P: 223-227
Sociodemographic and work-related differences in teachers’ attitude towards and perceived stress from emergency remote teaching during the COVID-19 pandemic

Kristin Kalo
Clemens Koestner
Pavel Dietz
ResearchOpen Access10 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
REMBI: Recommended Metadata for Biological Images—enabling reuse of microscopy data in biology

Bioimaging data have significant potential for reuse, but unlocking this potential requires systematic archiving of data and metadata in public databases. We propose draft metadata guidelines to begin addressing the needs of diverse communities within light and electron microscopy. We hope this publication and the proposed Recommended Metadata for Biological Images (REMBI) will stimulate discussions about their implementation and future extension.

Ugis Sarkans
Wah Chiu
Alvis Brazma
Comments & Opinion21 May 2021
Nature Methods

Volume: 18, P: 1418-1422
Magnetism, symmetry and spin transport in van der Waals layered systems

Spintronic properties of layered materials combining magnetism and strong spin–orbit coupling can be tailored by proper optimization of chemical interactions and structural material symmetries. This Review draws a route to achieving best performing material design for reaching the upper limit of spin–orbit torque efficiency in switching magnetization.

Hidekazu Kurebayashi
Jose H. Garcia
Stephan Roche
Reviews12 Jan 2022
Nature Reviews Physics

Volume: 4, P: 150-166
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Bloemeke et al. develop a method for measuring Aβ oligomers in plasma to diagnose Alzheimer’s Disease. Correlation analysis between cerebral spinal fluid and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on ApoE ε4 status.

Lara Blömeke
Fabian Rehn
Dieter Willbold
ResearchOpen Access10 Dec 2024
Communications Medicine

Volume: 4, P: 1-13
Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

Martin Mollenhauer
Dennis Mehrkens
Volker Rudolph
ResearchOpen Access18 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
Exploratory digital outcome measures of motor sign progression in Parkinson’s disease patients treated with prasinezumab

Kirsten I. Taylor
Florian Lipsmeier
Stefano Zanigni
ResearchOpen Access16 Jun 2025
npj Digital Medicine

Volume: 8, P: 1-12
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals

Stephan Thrum
Miriam Sommer
Ulf Wagner
ResearchOpen Access05 Aug 2022
International Journal of Obesity

Volume: 46, P: 1883-1891
Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls

Stephan Heinzel
Christian Kaufmann
Norbert Kathmann
ResearchOpen Access23 Sept 2021
Scientific Reports

Volume: 11, P: 1-11

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