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Showing 1–19 of 19 results
Advanced filters: Author: Steven Quake Clear advanced filters

  • Understanding the organism-wide molecular effects of spaceflight becomes increasingly critical as space exploration accelerates. Here, the authors show that miRNAs mediate microgravity-induced adaptations via extracellular matrix, DNA damage and developmental pathways, as shown by small RNA profiling in 13 organs of mice during and after spaceflight.

    • Friederike Grandke
    • Shusruto Rishik
    • Andreas Keller
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • In this study, the authors model the current mechanical properties of the seafloor of Jupiter’s icy moon Europa, and find those rocks to be too strong to allow the kind of fracturing that, on Earth, enables rock–water chemical reactions on which chemosynthetic life relies.

    • Paul K. Byrne
    • Henry G. Dawson
    • Douglas A. Wiens
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromosome-scale genome for T. vaginalis and assemblies of other bird and mammal-infecting species, identifying gene functions implicated in the spillover of trichomonads from birds to humans.

    • Steven A. Sullivan
    • Jordan C. Orosco
    • Jane M. Carlton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Nature Biotechnology asks a selection of researchers about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications.

    • Ido Amit
    • David Baker
    • Tian Zhang
    Special Features
    Nature Biotechnology
    Volume: 34, P: 270-275

  • Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

    • George Crowley
    • Robert C. Jones
    • Stephen R. Quake
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The coda correlation wavefield technique provides a powerful tool for surveying planetary interiors using only data from a single station. Its application to the SEIS seismometer on the InSight lander, which has been providing unique data on the interior of Mars since 2018, is a promising example of what it can bring to planetary seismology studies.

    • Steven J. Gibbons
    News & Views
    Nature Astronomy
    Volume: 6, P: 1235-1236

  • Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

    • Camille Ezran
    • Shixuan Liu
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 185-196

  • Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

    • Antoine de Morree
    • Iwijn De Vlaminck
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 173-184

  • Given the accumulation of DNA sequence data sets at ever-faster rates, what are the key factors you should consider when using distributed and multicore computing systems for analysis?

    • Michael C Schatz
    • Ben Langmead
    • Steven L Salzberg
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 691-693

  • Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

    • Shixuan Liu
    • Camille Ezran
    • James E. Ferrell Jr.
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

    • Marco Colonna
    • Genevieve Konopka
    • Naomi Habib
    Reviews
    Nature Neuroscience
    Volume: 27, P: 2310-2325