Mutations in the genes that encode the thyroid hormone receptors (THRs),THRA and THRB, result in resistance to thyroid hormone disorders, RTHα and RTHβ, respectively. In this Review, the authors discuss mutations that have been identified in patients with RTH and mouse models of these disorders that have contributed to understanding the physiology and functions of THRs.
- Tânia M. Ortiga-Carvalho
- Aniket R. Sidhaye
- Fredric E. Wondisford