Regulation of CD4 and CD8 expression during thymic development is a classical model to study control of lineage determination. Here the authors show that Brd1 epigenetically marks CD8 enhancer for activation by mediating H3K14 acetylation, which is necessary for establishing the CD8 T-cell lineage.
- Yuta Mishima
- Changshan Wang
- Atsushi Iwama
