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Non-coding RNAs in lipid metabolism and their roles in atherosclerosis

In this Review, Moore and co-workers provide an overview of the mechanisms and functions of microRNAs and long non-coding RNAs in vascular biology and the regulation of lipid metabolism, as well as the effects of non-coding RNAs on atherosclerotic plaque formation and progression.

Tamer Sallam
Coen van Solingen
Kathryn J. Moore
Reviews02 Jan 2026
Nature Reviews Cardiology

P: 1-22
Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

David A. Salisbury
David Casero
Tamer Sallam
Amendments and Corrections22 Feb 2023
Nature Metabolism

Volume: 5, P: 530
Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

David A. Salisbury
David Casero
Tamer Sallam
Amendments and Corrections18 Jul 2022
Nature Metabolism

Volume: 4, P: 960
Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain

Mapping of multi-omic molecular quantitative trait loci associated with tandem repeat size variation in up to 4,412 human brain samples from 1,597 donors offers insights into how these variants affect gene regulation and mediate disease risk.

Ya Cui
Frederick J. Arnold
Wei Li
Research14 Jan 2025
Nature Genetics

Volume: 57, P: 369-378
Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter activation.

Zhengyi Zhang
An-Chieh Feng
Tamer Sallam
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-9
Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

Salisbury et al. show that hepatic lipogenic mRNA is regulated by m⁶A modifications in a sex-dependent and dietary-dependent manner, contributing to sex-specific differences in hepatic lipid metabolism.

David A. Salisbury
David Casero
Tamer Sallam
Research19 Jul 2021
Nature Metabolism

Volume: 3, P: 940-953
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis, which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.

Tamer Sallam
Marius C. Jones
Peter Tontonoz
Research11 May 2016
Nature

Volume: 534, P: 124-128
Lnc-ing microRNA activity to atheroprotection

Cholesterol accumulation in cells and blood vessels promotes the development of vascular diseases. The long non-coding RNA CHROME can help clear excess cholesterol and provide protection from atherosclerosis.

Tamer Sallam
Peter Tontonoz
News & Views03 Dec 2018
Nature Metabolism

Volume: 1, P: 10-11
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

The conserved long noncoding RNA MeXis has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote cholesterol efflux.

Tamer Sallam
Marius Jones
Peter Tontonoz
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 304-312

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Non-coding RNAs in lipid metabolism and their roles in atherosclerosis

Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

Author Correction: Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice

Transcriptional regulation of N⁶-methyladenosine orchestrates sex-dimorphic metabolic traits

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Lnc-ing microRNA activity to atheroprotection

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

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