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Scientific Reports (63)
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Showing 1–50 of 107 results

Advanced filters: Author: Taoyuan Yin Clear advanced filters

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade

As immune checkpoint therapy is more frequently used for cancer, side effects such as Stevens-Johson syndrome / toxic epidermal necrolysis (SJS/TEN) are becoming more common. Here the authors use single cell transcriptomics to implicate TNF and CXCL10 in recruitment of CXCR3⁺ cytotoxic T cell in SJS/TEN skin lesions.

Chun-Bing Chen
Shuen-Iu Hung
Wen-Hung Chung
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-19
The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

Ching-Mao Chang
Hsueh-Ting Chu
Hen-Hong Chang
ResearchOpen Access29 Apr 2015
Scientific Reports

Volume: 5, P: 1-11
Phosphorylation-dependent STAMBP drives the progression of pancreatic ductal adenocarcinoma by deubiquitinating and stabilizing BAG3

Yongkang Shi
Jun Gong
Renyi Qin
Research29 Jan 2026
Cell Death & Differentiation

P: 1-19
GLP-1 receptor agonists’ impact on cardio-renal outcomes and mortality in T2D with acute kidney disease

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been studied for their cardiovascular benefits in type 2 diabetes. Here, the authors show that GLP-1 RAs are associated with reduced mortality and improved cardio-renal outcomes in type 2 diabetes patients with acute kidney disease.

Heng-Chih Pan
Jui-Yi Chen
Vin-Cent Wu
ResearchOpen Access13 Jul 2024
Nature Communications

Volume: 15, P: 1-10
A retrospective study on the incidence of acute kidney injury and its early prediction using troponin-I in cooled asphyxiated neonates

Tze Yee Diane Mok
Min-Hua Tseng
Ming-Chou Chiang
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-7
Author Correction: Integrated rocksalt–polyanion cathodes with excess lithium and stabilized cycling

Yimeng Huang
Yanhao Dong
Ju Li
Amendments and Corrections31 Oct 2025
Nature Energy

Volume: 11, P: 151
GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation

Activation of neutrophil leukocytes is tightly regulated, and it is important to understand the molecular mechanisms of their response to physiological and pathological stimuli. Here authors show that the adhesion molecule G protein-coupled receptor 97 and its interaction partners play pivotal roles in neutrophil leukocyte activation both in anti-microbial response and in inflammatory diseases.

Tai-Ying Chu
Céline Zheng-Gérard
Hsi-Hsien Lin
ResearchOpen Access27 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells

Chi-Neu Tsai
Chia-Lung Tsai
Kai-Ping Chang
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities

The conserved surface polysaccharide poly-β-(1,6)-N-acetyl-D-glucosamine (PNAG) is a promising vaccine target but antibodies raised against PNAG have shown restricted efficacy. Here, the authors describe an effective n + 2 glycosylation strategy, with control over the degree of N-acetylation, that allows the iterative assembly of partially and fully deacetylated PNAG glycans and investigate their potential as vaccine candidates.

Kuo-Shiang Liao
Mu-Rong Kao
Yves S. Y. Hsieh
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis

Po-Hsiang Tsui
Ming-Chih Ho
Hsiang-Yang Ma
ResearchOpen Access08 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
The long non-coding RNA LOC441204 enhances cell growth in human glioma

Tzu-Kang Lin
Chang-Nen Chang
Kwang-Huei Lin
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Optical coherence tomography: A new strategy to image planarian regeneration

Yu-Sheng Lin
Chin-Chou Chu
Po-Hsiang Tsui
ResearchOpen Access10 Sept 2014
Scientific Reports

Volume: 4, P: 1-7
Circulating Tumour Cells as an Independent Prognostic Factor in Patients with Advanced Oesophageal Squamous Cell Carcinoma Undergoing Chemoradiotherapy

Po-Jung Su
Min-Hsien Wu
Chia-Hsun Hsieh
ResearchOpen Access17 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Integrated rocksalt–polyanion cathodes with excess lithium and stabilized cycling

Energy density and cyclability are often a trade-off for lithium-ion batteries. The authors develop cobalt- and nickel-free cathodes with both good cycling stability and high energy density through the integration of polyanion units into rocksalt structures.

Yimeng Huang
Yanhao Dong
Ju Li
Research23 Aug 2024
Nature Energy

Volume: 9, P: 1497-1505
DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis

Y-J Chen
J T Chang
A-J Cheng
Research31 Jul 2006
Oncogene

Volume: 26, P: 467-476
DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits

Hsiang-Cheng Chi
Chung-Ying Tsai
Kwang-Huei Lin
Research04 Aug 2020
Oncogene

Volume: 39, P: 5933-5949
Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota

Chia-Ying Lin
Chiao-Yun Lin
Chia-Yu Yang
ResearchOpen Access26 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Modulation of Endothelial Injury Biomarkers by Traditional Chinese Medicine LC in Systemic Lupus Erythematosus Patients Receiving Standard Treatments

Hen-Hong Chang
Shue-Fen Luo
Yu-Jen Chen
ResearchOpen Access05 Feb 2016
Scientific Reports

Volume: 6, P: 1-7
Wireless charging-mediated angiogenesis and nerve repair by adaptable microporous hydrogels from conductive building blocks

Traumatic brain injury can cause long-term disability and thus constitutes a substantial healthcare burden worldwide. Here, the authors report a conductive microporous hydrogel to improve angiogenesis and recovery of brain function in traumatic brain lesions.

Ru-Siou Hsu
Ssu-Ju Li
Shang-Hsiu Hu
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

Jer-Yuarn Wu, Fuu-Jen Tsai, Yuan-Tsong Chen and colleagues report a genome-wide association study of Kawasaki disease. They show that common variants near BLK and CD40 influence susceptibility to this acute childhood vasculitis.

Yi-Ching Lee
Ho-Chang Kuo
Jer-Yuarn Wu
Research25 Mar 2012
Nature Genetics

Volume: 44, P: 522-525
PACT-3D, a deep learning algorithm for pneumoperitoneum detection in abdominal CT scans

CT scans are routinely used to diagnose pneumoperitoneum. Here the authors present a deep learning model for detecting pneumoperitoneum in abdominal CT scans, validated on datasets from Taiwan and the US, showing high accuracy and potential to accelerate diagnosis and treatment in emergency care.

I-Min Chiu
Teng-Yi Huang
Kuei-Hong Kuo
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-7
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing

The safety of CRISPR-Cas9 editing is a concern. Here the authors use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the genome integrity after editing: they see large structural variants at on-target sites and unexpected large chromosomal deletions.

Hsiu-Hui Tsai
Hsiao-Jung Kao
John Yu
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-9
Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect

Projections from the anterior and posterior basolateral amygdala (pBLA) to the ventral hippocampus CA1 (vCA1) are heterogenous. Here the authors show that activating the pathway from pBLA to vCA1 calbindin 1 positive neurons has an anxiolytic effect in approach-avoidance tasks in mice.

Guilin Pi
Di Gao
Jian–Zhi Wang
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-15
Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity

Pei-Ying Chen
Eugene Yu-Chuan Kang
Wei-Chi Wu
ResearchOpen Access11 May 2022
Scientific Reports

Volume: 12, P: 1-8
Regulation of Pd single-atom coordination for enhanced photocatalytic oxidation of toluene to benzaldehyde

The design of active sites in single-atom photocatalysts has a large impact on the catalytic reactivity. Here single-atom Pd–O catalytic sites are engineered by regulating their coordination environments. The Pd–O₃ sites exhibit enhanced activity and selectivity for photocatalytic oxidation of toluene to benzaldehyde.

Ruiyi Sun
Xing Cao
Yadong Li
Research03 Apr 2025
Nature Synthesis

Volume: 4, P: 965-975
Effect of local anesthesia on pain scale and specimen adequacy in fine-needle aspiration biopsy of thyroid nodules for liquid-based cytology

Tsung-Lun Lee
Pei-Yin Wei
Shyh-Kuan Tai
ResearchOpen Access02 Nov 2022
Scientific Reports

Volume: 12, P: 1-7
Prediction of residual astigmatism in cataract surgery at different diameter zones using optical biometry measurement

Yin-Hsi Chang
Christy Pu
Chiun-Ho Hou
ResearchOpen Access11 Mar 2022
Scientific Reports

Volume: 12, P: 1-8
Cytoreductive nephroureterectomy for treatment of upper urinary tract urothelial carcinoma initially diagnosed as node-positive

Shu-Yu Wu
Chi-Ping Huang
Yao-Chou Tsai
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Outcomes and longitudinal trend of traumatic cataract wound dehiscence in patients with blunt ocular injury

Chiun-Ho Hou
Yu-Chin Lu
Kuan-Jen Chen
ResearchOpen Access14 Sept 2021
Scientific Reports

Volume: 11, P: 1-8
Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas

Yu-Chi Wang
Chi-Cheng Chuang
Pin-Yuan Chen
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children

Ting-An Yang
Ju-Yin Hou
Chih-Jung Chen
ResearchOpen Access25 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
Caesarean Section is associated with reduced perinatal cytokine response, increased risk of bacterial colonization in the airway, and infantile wheezing

Sui-Ling Liao
Ming-Han Tsai
Jing-Long Huang
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study

Kung-Hao Liang
Mei-Ling Cheng
Chau-Ting Yeh
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
Care cascade of tuberculosis infection treatment for people living with HIV in the era of antiretroviral therapy scale-up

Kuan-Yin Lin
Chia-Jui Yang
Chen-Hsiang Lee
ResearchOpen Access27 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

Interim analysis from the randomized phase 3 JUPITER-02 trial shows that the addition of anti-PD-1 toripalimab to standard gemcitabine/cisplatin as a first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma has manageable toxicity and improves progression-free survival, suggesting a potential new treatment standard in this setting.

Hai-Qiang Mai
Qiu-Yan Chen
Rui-Hua Xu
Research02 Aug 2021
Nature Medicine

Volume: 27, P: 1536-1543
Statistical laws of stick-slip friction at mesoscale

Whether stick-slip instabilities can give rise to avalanches of slip lengths is an outstanding issue in solid friction. Here, the authors demonstrated that there indeed exists a critical regime in which stick-slip friction can be described by a common set of statistical laws of avalanche dynamics.

Caishan Yan
Hsuan-Yi Chen
Penger Tong
ResearchOpen Access05 Oct 2023
Nature Communications

Volume: 14, P: 1-8
Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks

Metal–organic frameworks (MOFs) are attractive for encapsulating enzymes for industrial purposes because they can increase selectivity, stability, and/or activity of the enzymes. Here, the authors developed an economical solid-state mechanochemical method to encapsulate enzymes during MOF synthesis.

Tz-Han Wei
Shi-Hong Wu
Fa-Kuen Shieh
ResearchOpen Access01 Nov 2019
Nature Communications

Volume: 10, P: 1-8
Integration of biomimetic organoid-on-chip and 2D models advances the mechanistic Understanding of STEAP3-mediated regulation in intestinal viral infection

Yi-Wen Chen
Huan-Jung Chiang
Yu-Yin Shih
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon

Enterovirus 71 (EV71) is one of the causative agents of hand-food-mouth disease and to date, effective vaccines or antivirals against the disease have not been developed. Here, the authors show that blocking miR-146a upregulation induced upon EV71 infection can have a positive effect on the resolution of infection.

Bing-Ching Ho
I-Shing Yu
Sung-Liang Yu
Research24 Feb 2014
Nature Communications

Volume: 5, P: 1-12
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Building the world’s first truly global medical foundation model

Yih Chung Tham
Jocelyn Hui Lin Goh
Dinah Zur
Correspondence08 Sept 2025
Nature Medicine

Volume: 31, P: 3580-3585
Giant gauge factor of Van der Waals material based strain sensors

The Gauge factor (GF) enhancement in strain sensors remains a key challenge. Here the authors leverage the piezoelectric and photoelectric effects in a class of van der Waals materials to tune the GF, and obtain a record GF up to 3933 for a SnS₂-based strain sensor.

Wenjie Yan
Huei-Ru Fuh
Han-Chun Wu
ResearchOpen Access01 Apr 2021
Nature Communications

Volume: 12, P: 1-9
Quantitative imaging of ultrasound backscattered signals with information entropy for bone microstructure characterization

Chiao-Yin Wang
Sung-Yu Chu
Po-Hsiang Tsui
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung-Mu Yang
I-Hsuan Alan Chen
Hsin-Chih Yeh
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Vitamin D deficiency, cardiothoracic ratio, and long-term mortality in hemodialysis patients

Heng-Jung Hsu
I-Wen Wu
Chin-Chan Lee
ResearchOpen Access05 May 2020
Scientific Reports

Volume: 10, P: 1-11
Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia

Ming-Horng Tsai
Jen-Fu Hsu
Jang-Jih Lu
ResearchOpen Access24 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
UGT2B28 genomic variation is associated with hepatitis B e-antigen seroconversion in response to antiviral therapy

Kung-Hao Liang
Chih-Lang Lin
Chau-Ting Yeh
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Verifying the accuracy of self-reported smoking behavior in female volunteer soldiers

Wei-Hung Chan
Ching-Huang Lai
Yu-Lung Chiu
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-6
Formation and characteristics of biomimetic mineralo-organic particles in natural surface water

Cheng-Yeu Wu
Jan Martel
John D. Young
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-11

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