Nature Search

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model

Skin-targeted siRNA therapies require optimized delivery to achieve therapeutic efficacy. Here, authors show that increasing conjugate hydrophobicity enhances siRNA skin retention and gene silencing in porcine and human models while limiting systemic tissue exposure.

Hassan H. Fakih
Mohammad Zain UI Abideen
Julia F. Alterman
ResearchOpen Access03 Feb 2026
Nature Communications

P: 1-11
Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state

The microbiota influences the cytotoxicity of chemotherapy in patients with colorectal cancer but the impact on metastatic relapse is less clear. Here, the authors report that chemotherapy-induced intestinal mucositis induces systemic immune changes via production the microbial metabolite, indole-3-propionic acid (IPA), preventing metastases.

Ludivine Bersier
L. Francisco Lorenzo-Martin
Tatiana V. Petrova
ResearchOpen Access15 Dec 2025
Nature Communications

Volume: 17, P: 1-23
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.

Ayush Giri
Jacklyn N. Hellwege
Todd L. Edwards
Research21 Dec 2018
Nature Genetics

Volume: 51, P: 51-62
Small-scale pig farmers’ behavior, silent release of African swine fever virus and consequences for disease spread

Solenne Costard
Francisco J. Zagmutt
Dirk Udo Pfeiffer
ResearchOpen Access27 Nov 2015
Scientific Reports

Volume: 5, P: 1-9
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.

Peter K. Joshi
Nicola Pirastu
James F. Wilson
ResearchOpen Access13 Oct 2017
Nature Communications

Volume: 8, P: 1-13
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.

Adriana I. Iglesias
Aniket Mishra
Stuart MacGregor
ResearchOpen Access14 May 2018
Nature Communications

Volume: 9, P: 1-11
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
Pangenome graph construction from genome alignments with Minigraph-Cactus

Constructing genome graphs directly from genome assemblies overcomes single-reference bias.

Glenn Hickey
Jean Monlong
Benedict Paten
Research10 May 2023
Nature Biotechnology

Volume: 42, P: 663-673
Towards complete and error-free genome assemblies of all vertebrate species

The Vertebrate Genome Project has used an optimized pipeline to generate high-quality genome assemblies for sixteen species (representing all major vertebrate classes), which have led to new biological insights.

Arang Rhie
Shane A. McCarthy
Erich D. Jarvis
ResearchOpen Access28 Apr 2021
Nature

Volume: 592, P: 737-746
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants

Here, the authors report a genome-wide association analysis for corneal resistance factor (CRF), a measure of corneal biomechanical properties relevant to a number of corneal diseases. They identify 135 loci associated with CRF and use fine-mapping and ATAC-seq in human cornea cell lines to identify putative causal variants affecting gene expression.

Xinyi Jiang
Nefeli Dellepiane
Veronique Vitart
ResearchOpen Access11 Dec 2020
Communications Biology

Volume: 3, P: 1-12
Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Lynsey S. Hall
Mark J. Adams
Andrew M. McIntosh
ResearchOpen Access10 Jan 2018
Translational Psychiatry

Volume: 8, P: 1-12
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Helen R. P. Phillips
Elizabeth M. Bach
Nico Eisenhauer
ResearchOpen Access21 May 2021
Scientific Data

Volume: 8, P: 1-12
Benzodiazepine use and neuroimaging markers of Alzheimer’s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort

Quentin Gallet
Vincent Bouteloup
Thomas Desmidt
Research10 Dec 2021
Neuropsychopharmacology

Volume: 47, P: 1114-1120
3D multiscale imaging of human vocal folds using synchrotron X-ray microtomography in phase retrieval mode

Lucie Bailly
Thibaud Cochereau
Elodie Boller
ResearchOpen Access18 Sept 2018
Scientific Reports

Volume: 8, P: 1-20
Community-specific evaluation of tool affordances in wild chimpanzees

Thibaud Gruber
Martin N. Muller
Klaus Zuberbühler
ResearchOpen Access03 Nov 2011
Scientific Reports

Volume: 1, P: 1-7

Search

Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model

Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Small-scale pig farmers’ behavior, silent release of African swine fever virus and consequences for disease spread

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Pangenome graph construction from genome alignments with Minigraph-Cactus

Towards complete and error-free genome assemblies of all vertebrate species

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Benzodiazepine use and neuroimaging markers of Alzheimer’s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort

3D multiscale imaging of human vocal folds using synchrotron X-ray microtomography in phase retrieval mode

Community-specific evaluation of tool affordances in wild chimpanzees

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