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Double Asteroid Redirection Test (DART) mission impact on asteroid Dimophos resulted in an elliptical ejecta plume. Here, the authors show that this elliptical ejecta is due to the curvature of the asteroid and makes kinetic momentum transfer less efficient.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Data-driven surrogate models are used in computational physics and engineering to greatly speed up evaluations of the properties of partial differential equations, but they come with a heavy computational cost associated with training. Pestourie et al. combine a low-fidelity physics model with a generative deep neural network and demonstrate improved accuracy–cost trade-offs compared with standard deep neural networks and high-fidelity numerical solvers.

Dykes are the main magma pathway through the Earth crust. Dykes are assumed to form by hydraulic fracturing through elastic rocks. We show how dykes emplaced in the deep ductile crust grow through very rapid ductile deformation of their host rocks.

Superradiance is usually driven by light-mediated couplings, leaving the role of direct emitter interactions unclear. Now, it is shown that dipole–dipole interactions in diamond spins drive self-induced pulsed and continuous superradiant masing.

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Strong lasing effects similar to those in the optical regime can occur at 1.5–2.1 Å wavelengths during high-intensity XFEL-driven Kα₁ lasing of copper and manganese.

In JAK2V617F mutant myeloproliferative neoplasms (MPN), inflammation impacts clinical outcomes. This study uncovers that the NLRP3 inflammasome drives thrombocytosis, granulocytosis, HSPC expansion, splenomegaly, and bone marrow fibrosis in MPN

HIV remission of more than 6 years was achieved in a patient with functional viral co-receptors after CCR5 wild-type/Δ32 allogeneic stem cell transplantation, providing evidence of other mechanisms that can be harnessed to attain long-term remission.

Here the authors provide a comprehensive evaluation of important pre-analytical variables affecting extracellular RNA quantification and analysis in the exRNAQC study, examining eight RNA purification methods, ten blood collection tubes, and three time intervals for blood processing.

A simple transport model infers a material’s electronic dimensionality from standard transport measurements, revealing temperature-, doping- and alloying-driven shifts between low-dimensional and 3D transport in SrTiO₃, Bi₂O₂Se and Pb_1-xSn_xTe.

Current digital hardware struggles with high computational demands in applications such as probabilistic AI. Here, authors present a small-scale thermodynamic computer composed of eight RLC circuits, demonstrating Gaussian sampling and matrix inversion, suggesting potential speed and energy efficiency advantages over digital GPUs.

Homologous recombination rearranges genetic information during meiosis to generate new combinations in the genome. Here, the authors report direct, single-individual detection of recombination in primates and humans using long-read sequencing.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Like cells in a body, social insects cooperate to maintain colony health. This study reveals that ants have evolved a chemical signalling system that alerts nestmates when their own immunity is insufficient to overcome infection, enabling efficient colony-level disease defence.

Here, the authors found that human NAT16 acetylates histidine in vitro and in vivo. Biochemical and structural characterisation uncovered a double-GNAT fold with distinct active site architecture that is conserved across species.

This study reports the creation of a model thermodynamic engine that is fuelled by the energy difference resulting from changing the statistics of a quantum gas from bosonic to fermionic.

Here, the authors examine the mechanisms behind cheatgrass’s successful invasion of North American ecosystems. Their genetic analyses and common garden experiments demonstrate that multiple introductions and migrations facilitated cheatgrass local adaptation.

Useful materials must satisfy multiple objectives. The Pareto front expresses the trade-offs of competing objectives. This work uses a self-driving laboratory to map out the Pareto front for making highly conductive coatings at low temperatures.

High-temperature behaviour of thermopower is special in cuprates, allowing for theory-experiment comparisons. Wang et al. use quantum Monte Carlo to compute high temperature thermopower in the Hubbard model, demonstrating qualitative and quantitative agreement with experiments across multiple cuprate families.

Structural analyses of antibody-virus complexes offer critical insights into immune recognition mechanisms. In this report, we present how a patient-derived IgG recognizes a quaternary epitope on EEEV particles through strictly bivalent interactions.

An on-chip integrated wavelength demultiplexer designed using an inverse computational algorithm is experimentally demonstrated. 1,300 and 1,550 nm wavelength light is sorted in a device area of just 2.8 × 2.8 μm².

Van der Waals heterostructures can be combined with metallic nanostructures to enable enhanced light–matter interaction. Here, the authors fabricate a broadband mechanical electro-optical modulator using a graphene/hexagonal boron nitride vertical heterojunction, suspended over a gold nanostripe array.

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

It has been shown previously that substrate viscoelasticity affects surface wettability. Here the authors observe a wetting transition during drying of droplets on such substrates and elucidate it with high resolution force field measurements thereby determining its dependence on substrate properties.

A high-resolution spectroscopic tool is demonstrated using the stochastically fluctuating intensity spikes in time and energy domains of a self-amplified spontaneous emission X-ray free-electron laser.

Ian Henderson and colleagues report fine-scale mapping and characterization of recombination rates in Arabidopsis thaliana. They find an enrichment of recombination hot spots overlapping transcription start and termination sites, as well as that hot spot–associated promoter regions show elevated levels of chromatin marks, including high H2A.Z, high H3K4me3 and low nucleosome density.

Air surveillance offers a potential means of monitoring airborne pathogens without the need for individual sampling. Here, the authors perform continuous air sampling in 15 community settings in the US for 29 weeks and demonstrate its feasibility for routine detection of SARS-CoV-2 and other respiratory pathogens.

Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

While high–harmonic generation from gases, and more recently also from solids, has been extensively studied, there is little data on HHG from liquids. Here, Luu et al. experimentally demonstrate and study HHG up to 27^th order from the bulk of liquid water and different alcohols.

A thin liquid coating on a fibre can break up into droplets due to the Plateau–Rayleigh instability, as for instance on a spider web. Here, Haefner et al. show that the growth rate of the droplet undulations strongly depends on the fibre–liquid boundary condition and slip accelerates the instability.

Finding broadband terahertz emitters and detectors is key to developing practical terahertz technologies and to exploring fundamental nonlinear optics. Luo et al.show that split-ring-resonator metamaterials of a few tens of nanometres thickness can efficiently generate terahertz pulses up to 4 THz.

Liver metastases are a clinical problem, with low responses to immunotherapy. Here, authors coordinate expression of tumor antigens IFNα and IL-12 in liver and tumor associated macrophages to rejuvenate tumor reactive T cells and eliminate liver metastases.

Poly(vinylidene fluoride) exhibits a negative longitudinal piezoelectric coefficient. In situ X-ray diffraction measurements suggest that this effect is dependent on electromechanical coupling between the intermixed crystalline lamellae and amorphous regions.