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A general approach to simplifying quantum logic circuits—the ‘programs’ of quantum computers—is described and demonstrated on a platform based on photonic qubits.

The authors demonstrate high-fidelity multi-tone electronic control of trapped-ion qudits up to d=8 levels, enabling efficient SU(d) operations and showcasing advantage by implementing Grover’s search algorithm using encoding in a single qudit, rather than in multiple qubits.

Quantum computing has advantages over conventional computing, but the complexity of quantum algorithms creates technological challenges. Here, an architecture-independent technique, that simplifies adding control qubits to arbitrary quantum operations, is developed and demonstrated.

Researchers present a photonic demonstration of a full quantum algorithm without knowing the answer in advance. The unknown eigenvalues are truly calculated by the iterative phase estimation algorithm circuit. The demonstrated scheme is essential for practical applications of the phase estimation algorithm, including quantum simulations, quantum metrology and factoring.

A fully programmable two-qubit quantum processor with more than 200 components is demonstrated by using silicon photonic circuits. A two-qubit quantum approximate optimization algorithm and simulation of Szegedy quantum walks are implemented.

Waves are ubiquitous in nature and occur across various scales and settings. In this Primer, Jafarzadeh et al. discuss techniques for preprocessing and analysing waves, including information on choosing the appropriate methods based on wave properties, and present worked examples using synthetic datasets.

A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

Xenotransplantation of a genetically edited pig kidney with a thymic autograft into a brain-dead human for 61 days with immunosuppression resulted in stable kidney function without proteinuria, and xenograft rejection was treated and reversed by the end of the study.

Astrochronology of a core in Maryland suggests that the onset of the Paleocene-Eocene Thermal Maximum (PETM) warming lasted about 6 thousand years. These data are more consistent with astronomical forcing than an extraterrestial trigger for the PETM.

A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

This study uses human astrocytes and glioma tumorspheres to generate an atlas of mutant-IDH1-induced epigenomic reprogramming. The findings have implications for understanding mutant IDH function and for optimizing approaches to target IDH-mutant tumors.

Universal quantum logic operations with fidelity exceeding 99%, approaching the threshold of fault tolerance, are realized in a scalable silicon device comprising an electron and two phosphorus nuclei, and a fidelity of 92.5% is obtained for a three-qubit entangled state.

Russo et al. show that context-specific place cell assemblies support hippocampal integration of past experiences into future plans during goal-directed behavior and propose a biophysical mechanism behind the formation of goal dependent theta sequences.

Sleep rearranges the firing patterns of excitatory projection neurons in zebra finch songbirds. Patterned inhibition is implicated in maintaining stable songs in spite of the instability in the projection neuron population.

Spatial working memory is known to involve the prefrontal cortex and the hippocampus, but the specificities of the connection have been unclear; now, a direct path between these two areas is defined that is necessary for the encoding of spatial cues in mice, but is not required for the maintenance or retrieval of these cues.

Using at-home intracranial DBS recordings in PD participants, the authors found subcortical beta has an inverse effect on cortical slow-wave in NREM sleep, rises before awakenings and found >88% accuracy in NREM vs Wake classification in brief 5 s epochs.

Quantum channel correction could provide a remedy to unavoidable losses in long-distance quantum communication, but the break-even point has escaped demonstration so far. Here, the authors fill this gap using distillation by heralded amplification, followed by teleportation of entanglement.

Theta- and gamma-frequency oscillatory synchrony correlates with spatial working memory performance. Here the authors report increases in theta-gamma cross-frequency coupling as a compensatory mechism associated with better working memory performance in models of cognitive dysfunction in mice.

The pedunculopontine nucleus (PPN) is a target for deep brain stimulation for the control of gait and postural disability, but its role in gait control is not understood. Here, using extracellular single-unit recordings in awake patients, the authors show that neurons in the PPN respond to limb movement and imagined gait by dynamically changing network activity and decreasing alpha phase locking.

Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells.

Using pathway-specific optogenetic inhibition, the authors demonstrate that projections from the mediodorsal thalamus to prefrontal cortex support the maintenance of working memory, while prefrontal–thalamic projections support subsequent choice selection. Thalamo–prefrontal projections have a circuit-specific role in sustaining prefrontal delay-period activity, a neuronal signature required for successful task performance.

Using depth electrodes in human patients, scientists at the Mayo Clinic found that the map of the body in motor cortex extends deep into the central sulcus. Unexpectedly, the nonsomatotopic ‘Rolandic motor association’ (RMA) area interrupts this organization.

Topological mechanical metamaterials have been considered effective for energy manipulation via edge states, but manipulating these states remains challenging. Here, a Kresling origami mechanical metamaterial hosts multiple topological edge states at finite frequencies, which can be manipulated and transferred across the boundaries of the system by adjusting the lattice torsion.

Nick Spencer et al. made simultaneous multi-site electrophysiological recordings with video imaging of colonic wall movements from ex vivo mouse colon, in order to correlate propulsion of content with underlying electrical signals from the smooth muscle. Their results demonstrate that excitatory and inhibitory junction potentials are synchronized in both the proximal and distal colon, suggesting that the enteric nervous system network communicates over a longer range than previously expected.

Polaritonics is the physics of strongly coupled light–matter states that studies condensates and superfluids of bosonic quasiparticles in solid-state systems. Coherent flows of exciton–polaritons can be used for classical and quantum information processing, offering advantages of full optical control and read-out.