Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. This Review discusses the contribution of NF-κB to chronic liver disease, with a particular focus on the role of NF-κB in different hepatic cell compartments and its effects on chronic inflammation and fibrosis as events that set the stage for the development of HCC.
- Tom Luedde
- Robert F. Schwabe
