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Showing 1–4 of 4 results
Advanced filters: Author: Trevor Feinstein Clear advanced filters

  • The PI3K-AKT1-PTEN signaling pathway has an important role in hormone receptor positive, HER2 negative (HR + /HER-) breast cancer progression and therapy resistance. Here, the author report the efficacy and safety of afuresertib, a pan AKT inhibitor, plus fulvestrant (hormone therapy) in patients with pretreated, HR-positive, HER2- negative advance breast cancer.

    • Pin Zhang
    • Tao Sun
    • Binghe Xu
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-11

  • Authors show that all individuals have asymmetrically glycosylated IgGs—the glycans on each of the Fc protomers are not identical. Asymmetrically monofucosylated IgGs drive dengue disease and are functionally similar to afucosylated IgGs.

    • Tala Azzam
    • Stylianos Bournazos
    • Eric J. Sundberg
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • V1298 Tau b is a 20–30-Myr-old Jovian-sized planet with a haze-free, metal-poor atmosphere and a potentially hot interior. These properties suggest that V1298 Tau b formed in situ via pebble accretion and that it is still evolving and likely to become a Neptune- or sub-Neptune-sized planet.

    • Saugata Barat
    • Jean-Michel Désert
    • Erik A. Petigura
    ResearchOpen Access
    Nature Astronomy
    Volume: 8, P: 899-908