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Showing 1–50 of 110 results

Advanced filters: Author: Tzu Chun Chung Clear advanced filters

Clinical impact of pharmacogenetic risk variants in a large chinese cohort

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Chun-Yu Wei
Ming-Shien Wen
Pui-Yan Kwok
ResearchOpen Access09 Jul 2025
Nature Communications

Volume: 16, P: 1-15
The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Hsin-Chou Yang
Pui-Yan Kwok
Jer-Yuarn Wu
ResearchOpen Access15 Oct 2025
Nature

Volume: 648, P: 117-127
Population-specific polygenic risk scores for people of Han Chinese ancestry

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Hung-Hsin Chen
Chien-Hsiun Chen
Cathy S. J. Fann
ResearchOpen Access15 Oct 2025
Nature

Volume: 648, P: 128-137
Cytoreductive nephroureterectomy for treatment of upper urinary tract urothelial carcinoma initially diagnosed as node-positive

Shu-Yu Wu
Chi-Ping Huang
Yao-Chou Tsai
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Gender differences in the association between alcohol use disorder and infertility: a nationwide population-based cohort study in Taiwan

Huei-Ting Tsai
Yao-Ching Huang
Wu-Chien Chien
ResearchOpen Access06 Jan 2026
Scientific Reports

P: 1-16
Evaluating the “holiday season effect” of hospital care on the risk of mortality from pulmonary embolism: a nationwide analysis in Taiwan

Duan-Pei Hung
Shu-Man Lin
Ching-Hui Loh
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-7
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

Post-translational modifications regulate tumorigenesis and cancer therapy sensitivity. Here, the authors show that N-glycosylation defective Interleukin-6 (deNG-IL6) switches downstream signalling pathway from JAK-STAT3 to SRC-YAP axis and lung cancer cells secrete deNG-IL6 to promote metastasis and tyrosine kinase inhibitor resistance.

Chun-Hua Hung
Shang-Yin Wu
Wu-Chou Su
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-24
AAV-mediated intracerebral expression of an α-synuclein-targeting intrabody improves motor functions in aged rats

Kuo-Jen Wu
Yu-Sung Chiu
Yun-Hsiang Chen
ResearchOpen Access07 Jan 2026
Scientific Reports

P: 1-18
Author Correction: HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

Zhao-Jun Pan
Wei-Lun Wei
Shih-Shun Lin
Amendments and CorrectionsOpen Access30 Jul 2025
Nature Communications

Volume: 16, P: 1
Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice

Chung-Lin Tsai
Der-Shan Sun
Hsin-Hou Chang
ResearchOpen Access14 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Role of Cholecystectomy in Choledocholithiasis Patients Underwent Endoscopic Retrograde Cholangiopancreatography

Chi-Chih Wang
Ming-Chang Tsai
Chun-Che Lin
ResearchOpen Access18 Feb 2019
Scientific Reports

Volume: 9, P: 1-7
Hypertension and chronic kidney disease affect long-term outcomes in patients with stable coronary artery disease receiving percutaneous coronary intervention

Mao-Jen Lin
Wen-Chieh Yang
Han-Ping Wu
ResearchOpen Access05 Dec 2018
Scientific Reports

Volume: 8, P: 1-8
Evaluating China’s carbon neutrality transition: a system framework using a two-stage dynamic non-radial directional distance function

Xiangyu Teng
Yixin Xie
Yung-ho Chiu
ResearchOpen Access09 Dec 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
Effect of Statins on Renal Function in Chronic Kidney Disease Patients

Ping-Jen Hu
Mei-Yi Wu
Yuh-Feng Lin
ResearchOpen Access02 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

Tsung-Mu Yang
I-Hsuan Alan Chen
Hsin-Chih Yeh
ResearchOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Impact of early failure of induction on transplant outcomes in Hodgkin lymphoma

Yu-Sung Chang
Wan-Chen Hsieh
Tai-Chung Huang
Correspondence18 Dec 2025
Bone Marrow Transplantation

P: 1-3
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization

Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic target against pulmonary fibrosis.

Tzu-Han Lee
Chih-Fan Yeh
Kai-Chien Yang
ResearchOpen Access26 Aug 2020
Nature Communications

Volume: 11, P: 1-20
Associations between prenatal metal exposure, gene variants, and birth size in Taiwan Birth Panel Study

Chih-Fu Wei
Mei-Huei Chen
Pau-Chung Chen
Research12 Jan 2026
Pediatric Research

P: 1-10
The Prostate Health Index aids multi-parametric MRI in diagnosing significant prostate cancer

Yu-Hua Fan
Po-Hsun Pan
Tzu-Ping Lin
ResearchOpen Access05 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway

Tzu-Wei Yang
Wei-Hsiang Lee
Chun-Che Lin
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-13
Antimicrobial and anti-inflammatory potential of Angelica dahurica and Rheum officinale extract accelerates wound healing in Staphylococcus aureus-infected wounds

Wan-Ting Yang
Chun-Yen Ke
Ru-Ping Lee
ResearchOpen Access27 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Tobacco use disorder is associated with increased risk of cardiomyopathy in a population-based study from Taiwan

Pei-Yeh Yu
Ho-Tsung Hsin
Wu-Chien Chien
ResearchOpen Access01 Dec 2025
Scientific Reports

Volume: 16, P: 1-15
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA

Pancreatic Spint1 disruption causes glucose intolerance, reduced islet size, and decreased insulin synthesis and secretion. SPINT1 regulates HEPSIN’s modification of GLP1R/MAFA activation, vital for glucose control by β cells, linking it to diabetes.

Hsin-Hsien Lin
I-Shing Yu
Ming-Shyue Lee
ResearchOpen Access03 Dec 2024
Nature Communications

Volume: 15, P: 1-17
Conserved regulatory switches for the transition from natal down to juvenile feather in birds

Natal downs adapted for heat conservation transition to juvenile feathers that support simple flight during bird development. Here the authors characterize gene expression networks and epigenetic changes and use functional perturbations to characterize evolutionarily conserved regulatory switches that control this transition in birds.

Chih-Kuan Chen
Yao-Ming Chang
Wen‐Hsiung Li
ResearchOpen Access16 May 2024
Nature Communications

Volume: 15, P: 1-17
HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

Zhao-Jun Pan
Wei-Lun Wei
Shih-Shun Lin
ResearchOpen Access13 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes

Tzu-rong Su
Cay-huyen Chen
Min-jon Lin
Research24 Aug 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1220-1226
Bioresorbable, wireless dual stimulator for peripheral nerve regeneration

Wireless bioresorbable stimulators are promising therapeutic implants that naturally dissolve after use. Here, the authors developed a device that operates for months and enables simultaneous multi-site stimulation, preventing early muscle atrophy and accelerating reinnervation in nerve injury models.

Hak-Young Ahn
Jordan B. Walters
John A. Rogers
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-12
Association between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients

Chih-Chung Shiao
Yu-Hsing Chang
Chiu-Ching Huang
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Effect of field of view variation on CTP assessment of infarct core and penumbra in acute ischemic stroke

Chun-Han Liao
Yung-Yin Cheng
Yi-Jui Liu
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Integrating multi-polygenic scores for enhanced prediction of antidepressant treatment outcomes in an East Asian population

Shu-Chin Lin
Chiu-Ping Fang
Yen-Feng Lin
ResearchOpen Access28 Oct 2025
Neuropsychopharmacology

Volume: 51, P: 422-429
Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients

Tzu-Ning Yu
Ming-Jer Chen
Pin-Yao Lin
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
A potential peptide derived from cytokine receptors can bind proinflammatory cytokines as a therapeutic strategy for anti-inflammation

Shinn-Jong Jiang
Pei-I Tsai
Hao-Jen Hsu
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Author Correction: Continuous aerosol monitoring and comparison of aerosol exposure based on smoke dispersion distance and concentrations during oxygenation therapy

Chih‑Chieh Wu
Wei‑Lun Chen
Tzu‑Yao Hung
Amendments and CorrectionsOpen Access22 Nov 2023
Scientific Reports

Volume: 13, P: 1
Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.

Ren-You Pan
Mu-Tzu Chu
Shuen-Iu Hung
ResearchOpen Access08 Aug 2019
Nature Communications

Volume: 10, P: 1-13
Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas

Yu-Chi Wang
Chi-Cheng Chuang
Pin-Yuan Chen
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Polygenic height prediction for the Han Chinese in Taiwan

Chih-Hao Chang
Che-Yu Chou
Pui-Yan Kwok
ResearchOpen Access05 Feb 2025
npj Genomic Medicine

Volume: 10, P: 1-10
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

Terminally differentiated superficial epithelial cells continue dividing in the absence of DNA replication to quickly expand epithelial coverage during rapid growth.

Keat Ying Chan
Ching-Cher Sanders Yan
Chen-Hui Chen
Research27 Apr 2022
Nature

Volume: 605, P: 119-125
Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan

Chung-Feng Huang
Hsing-Tao Kuo
Ming-Lung Yu
ResearchOpen Access06 Dec 2021
Scientific Reports

Volume: 11, P: 1-10
A CMOS-integrated compute-in-memory macro based on resistive random-access memory for AI edge devices

Commercial complementary metal–oxide–semiconductor and resistive random-access memory technologies can be used to create multibit compute-in-memory circuits capable of fast and energy-efficient inference for use in small artificial intelligence edge devices.

Cheng-Xin Xue
Yen-Cheng Chiu
Meng-Fan Chang
Research14 Dec 2020
Nature Electronics

Volume: 4, P: 81-90
Enhanced Performance of GaN-based Ultraviolet Light Emitting Diodes by Photon Recycling Using Graphene Quantum Dots

Tzu-Neng Lin
Svette Reina Merden Santiago
Ya-Ju Lee
ResearchOpen Access02 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai-Lin Sheu
Chi-Ping Huang
Hsin‑Chih Yeh
ResearchOpen Access24 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Construction of intracellular asymmetry and asymmetric division in Escherichia coli

Establishing protein gradients for asymmetric cell division is fundamental across all kingdoms of life. Here the authors construct asymmetric cell division in E. coli by localizing the expression of RNA polymerase using an orthogonal unipolar scaffold, and restricting diffusion of its products.

Da-Wei Lin
Yang Liu
Hsiao-Chun Huang
ResearchOpen Access09 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

Drug hypersensitivity reactions can result in life-threatening epidermal necrosis caused by cytotoxic T lymphocytes and natural killer cells. Chung et al. show that an unusual form of granulysin secreted from these cells is largely responsible for the cell death (pages 1311–1313).

Wen-Hung Chung
Shuen-Iu Hung
Yuan-Tsong Chen
Research23 Nov 2008
Nature Medicine

Volume: 14, P: 1343-1350
A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine

Many AAA+ (ATPases associated with diverse cellular activities) proteins function as a hexamer to remodel protein substrates. Here, the authors report the discovery of a pentameric form of the Lon AAA+ protease and show that it plays a role in the substrate-dependent activation of the AAA+ protein.

Shanshan Li
Kan-Yen Hsieh
Chung-I Chang
ResearchOpen Access13 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC

Dai-Jung Chung
Chun-Hao Wang
Tzu-Tang Wei
Research02 Oct 2024
Cancer Gene Therapy

Volume: 31, P: 1734-1748
Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells

Guang-Yuh Chiou
Tzu-Wei Yang
Yuh-Jyh Jong
ResearchOpen Access19 May 2017
Scientific Reports

Volume: 7, P: 1-13
Identification of plant vacuolar transporters mediating phosphate storage

The plant vacuole acts as a storage compartment for inorganic phosphate and buffers cytoplasmic phosphate concentration. Here, Liu et al. identify a group of vacuolar phosphate transporters in Arabidopsisthat are required for plant growth in response to fluctuating availability of phosphate.

Tzu-Yin Liu
Teng-Kuei Huang
Tzyy-Jen Chiou
ResearchOpen Access31 Mar 2016
Nature Communications

Volume: 7, P: 1-11
Current and potential urological applications of botulinum toxin A

Botulinum toxin A (BoNT-A) is an approved treatment of neurogenic and idiopathic overactive bladder, and is also widely used for off-label treatment of a range of other lower urinary tract dysfunctions. Here, authors describe the effectiveness, safety and tolerability of intravesical BoNT-A injections as a treatment of a wide range of urological conditions.

Yuan-Hong Jiang
Chun-Hou Liao
Hann-Chorng Kuo
Reviews11 Aug 2015
Nature Reviews Urology

Volume: 12, P: 519-533
Neurophysiological and executive function differences among underweight, overweight, and normal-weight children and adolescents

Yi-Chun Lin
Yu-Tzu Chang
Yu-Chi Liao
Research03 Dec 2025
Pediatric Research

P: 1-10

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