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Showing 1–4 of 4 results
Advanced filters: Author: Ullas V. Chembazhi Clear advanced filters

  • Liver regeneration often fails during chronic liver disease. Here, the authors conduct multiomic profiling of human livers to demonstrate that RNA splicing is dysregulated in alcohol-associated liver disease, interfering with liver regeneration.

    • Ullas V. Chembazhi
    • Sushant Bangru
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Liver dysfunctions are understudied in myotonic dystrophy (DM1) but impact metabolic health, drug sensitivity and treatment paradigms for the affected population. Here, Dewald et al. generated liver-specific DM1 mice to demonstrate that CUG-repeat RNA toxicity predisposes the liver to MAFLD and drug metabolism defects.

    • Zachary Dewald
    • Oluwafolajimi Adesanya
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hepatocellular gene expression, metabolism, and lipid trafficking, resulting in NASH-like pathology.

    • Waqar Arif
    • Bhoomika Mathur
    • Auinash Kalsotra
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19