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Showing 1–5 of 5 results
Advanced filters: Author: Unmesh Jadhav Clear advanced filters

  • Intracellular redox state orchestrates a self-reinforcing circuit connecting hypoxia inducible factor 1α-dependent signalling with post-translational regulation of the metabolic enzyme isocitrate dehydrogenase 1 to govern intestinal stem cell fate.

    • Xi Chen
    • Krishnan Raghunathan
    • Jay R. Thiagarajah
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Mouse models of colorectal cancer show that adenoma formation following deletion of Apc is dependent on a proximity effect of mutant crypts and increased chromosome accessibility at specific enhancers.

    • Liam Gaynor
    • Harshabad Singh
    • Ramesh A. Shivdasani
    Research
    Nature
    Volume: 640, P: 231-239

  • Pancreatic ductal adenocarcinoma cells show a specific dependency on ornithine aminotransferase-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for this cancer.

    • Min-Sik Lee
    • Courtney Dennis
    • Nada Y. Kalaany
    Research
    Nature
    Volume: 616, P: 339-347

  • Zhang et al. identify Creb5 as a transcription factor that is required for induction of Prg4 expression by TGFβ and EGFR ligands. They show that Creb5 directly binds to two Prg4 promoter-proximal regulatory elements, working together with a more distal regulatory element to drive induction of Prg4 by TGFβ. These findings provide new insight into the molecular regulation of Prg4 expression in superficial zone articular chondrocytes.

    • Cheng-Hai Zhang
    • Yao Gao
    • Andrew B. Lassar
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17