Nature Search

CD4⁺ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Matthew Ho
Luca Paruzzo
Joseph A. Fraietta
Research15 Jan 2026
Nature Medicine

P: 1-15
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis

Here the authors use a range of approaches to examine the interplay between genetic variants linked to risk for polygenic skin diseases and transcription factors (TFs) important for skin homeostasis. The findings implicate dysregulated binding of specific TF families in risk for diverse skin diseases.

Douglas F. Porter
Robin M. Meyers
Paul A. Khavari
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-28
Regulation of RNA-binding proteins by small biomolecules

RNA-binding proteins (RBPs) are essential for gene regulation. Recent data reveal that small biomolecules (SBMs) such as sugars, nucleotides, metabolites and drugs bind to RBPs and regulate their function. This Review discusses the landscape of SBM-binding RBPs, the molecular basis of their interactions and their relevance to human diseases.

Weili Miao
Douglas F. Porter
Paul A. Khavari
Reviews06 Nov 2025
Nature Reviews Molecular Cell Biology

P: 1-21
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

Genomic analysis of 118 cervical tumors from Ugandan individuals identifies HPV-clade-specific differences in tumor DNA methylation, regulatory-region-associated histone marks, gene expression and pathway dysregulation.

Alessia Gagliardi
Vanessa L. Porter
Marco A. Marra
Research03 Aug 2020
Nature Genetics

Volume: 52, P: 800-810
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

In an analysis of long-term safety events in 783 patients treated with T cell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration analyses revealed no pathological insertions.

Julie K. Jadlowsky
Elizabeth O. Hexner
Joseph A. Fraietta
Research20 Jan 2025
Nature Medicine

Volume: 31, P: 1134-1144
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

Bacteria respond to stresses using two-component systems consisting of sensor kinases (SKs) and response regulators. Here, Francis et al. reveal three specific interaction mechanisms between a pair of SKs that are important for regulation of virulence in the pathogen Pseudomonas aeruginosa.

Vanessa I. Francis
Elaine M. Waters
Steven L. Porter
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-11
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

Volume: 57, P: 1598-1610
PROBER identifies proteins associated with programmable sequence-specific DNA in living cells

PROBER offers a method to identify proteins associated with the DNA sequence of interest and quantify differential binding caused by sequence variants in living cells.

Smarajit Mondal
Muthukumar Ramanathan
Paul A. Khavari
Research04 Aug 2022
Nature Methods

Volume: 19, P: 959-968
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Tchorz and colleagues identify a role for the RSPO–LGR4/5–ZNRF3/RNF43 module as master regulator of Wnt/β-catenin-mediated metabolic liver zonation and hepatic growth/size control during development, homeostasis and regeneration.

Lara Planas-Paz
Vanessa Orsini
Jan S. Tchorz
Research18 Apr 2016
Nature Cell Biology

Volume: 18, P: 467-479
Critical Assessment of Metagenome Interpretation: the second round of challenges

This study presents the results of the second round of the Critical Assessment of Metagenome Interpretation challenges (CAMI II), which is a community-driven effort for comprehensively benchmarking tools for metagenomics data analysis.

Fernando Meyer
Adrian Fritz
Alice Carolyn McHardy
ResearchOpen Access08 Apr 2022
Nature Methods

Volume: 19, P: 429-440
Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish

Dean Porter
Catherine Collins
Pierre Boudinot
ResearchOpen Access24 Jul 2025
npj Vaccines

Volume: 10, P: 1-16
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Whole-genome sequencing identifies a novel germline variant in the oncogene MITF, which is associated with the development of melanoma.

Satoru Yokoyama
Susan L. Woods
Kevin M. Brown
ResearchOpen Access13 Nov 2011
Nature

Volume: 480, P: 99-103
Unexpected diversity in socially synchronized rhythms of shorebirds

Socially synchronized rhythms in shorebirds were assessed during biparental incubation under natural circumstances and were exceptionally diverse, often not following the 24-h day, whereby risk of predation, not starvation, determined some of the variation in incubation rhythms.

Martin Bulla
Mihai Valcu
Bart Kempenaers
Research23 Nov 2016
Nature

Volume: 540, P: 109-113
Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus

Rebecca C. Lowry
David S. Milner
R. E. Sockett
ResearchOpen Access21 Mar 2019
Scientific Reports

Volume: 9, P: 1-15
MARES, a replicable pipeline and curated reference database for marine eukaryote metabarcoding

Vanessa Arranz
William S. Pearman
Libby Liggins
ResearchOpen Access03 Jul 2020
Scientific Data

Volume: 7, P: 1-8
Defining a research agenda for environmental wastewater surveillance of pathogens

Alexander G. Shaw
Catherine Troman
Julia Fitzner
Correspondence03 Aug 2023
Nature Medicine

Volume: 29, P: 2155-2157
Winter diversity and expression of proteorhodopsin genes in a polar ocean

Dan Nguyen
Roxane Maranger
Carlos Pedrós-Alió
Research20 Feb 2015
The ISME Journal

Volume: 9, P: 1835-1845
A seafloor habitat map for the Australian continental shelf

Vanessa Lucieer
Neville Barrett
Craig Johnson
ResearchOpen Access11 Jul 2019
Scientific Data

Volume: 6, P: 1-7
The French Muséum national d’histoire naturelle vascular plant herbarium collection dataset

Gwenaël Le Bras
Marc Pignal
Thomas Haevermans
ResearchOpen Access14 Feb 2017
Scientific Data

Volume: 4, P: 1-16

Search

CD4⁺ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy

Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis

Regulation of RNA-binding proteins by small biomolecules

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

PROBER identifies proteins associated with programmable sequence-specific DNA in living cells

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Critical Assessment of Metagenome Interpretation: the second round of challenges

Divergent B-cell repertoire remodelling by mRNA, DNA and live attenuated vaccines in fish

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Unexpected diversity in socially synchronized rhythms of shorebirds

Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus

MARES, a replicable pipeline and curated reference database for marine eukaryote metabarcoding

Defining a research agenda for environmental wastewater surveillance of pathogens

Winter diversity and expression of proteorhodopsin genes in a polar ocean

A seafloor habitat map for the Australian continental shelf

The French Muséum national d’histoire naturelle vascular plant herbarium collection dataset

Search

Quick links

Search

Filter By:

Search

Quick links