Search

High-resolution scanning tunnelling microscopy and spectroscopy are used to provide evidence for unconventional superconductivity in magic-angle twisted trilayer graphene.

Microscope control software allowed automatic machine learning-based detection of rare events in living cells and unattended operation of complex imaging assays. Performance was demonstrated by detailed analysis of processes during transient mitotic stages.

It is unclear whether bird migration patterns are restricted to interglacial periods or are maintained during glacial maxima. Somveille et al. apply a global migration simulation model to climate reconstruction to show that the prevalence of this phenomenon has likely been largely maintained up to 50,000 years ago.

This study presents a global analysis of seafloor roughness derived from marine gravity data and finds that residual roughness anomalies remain over large swaths of ocean floor. The Atlantic ocean floor that formed over mantle previously overlain by the Pangaea supercontinent displays anomalously low roughness, and attribute this observation to a sub-Pangaean supercontinental mantle temperature anomaly leading to slightly thicker than normal Atlantic crust. In contrast, ocean crust formed above Pacific superswells is not associated with basement roughness anomalies.

A protein condensate formed by multivalent interactions between the long non-coding RNA Xist and specific RNA-binding proteins drives the compartmentalization required to perpetuate gene silencing on the inactive X chromosome.

The ability to wiggle and stretch individual superconducting vortices with nanoscale precision enables unprecedented insight into their dynamics and the properties of the superconductor that supports them.

Neptunium was the first actinide to be artificially synthesized, yet its chemistry has remained relatively unexplored. Most neptunium chemistry involves the neptunyl di(oxo) motif, and transuranic compounds with only one metal–ligand multiple bond are generally rare. Now, a stable complex of neptunium in the +5 oxidation state has been isolated that features a single terminal Np–O multiple bond.

Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

The onset of rigidity in a two-dimensional colloidal glass-forming system is identified by the formation and merging of locally rigid domains in which particles move in a cooperative manner.

FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired formation of clathrin-coated pits in T cells.

Landau levels in graphene are not equidistant so that transitions between them can be individually probed. Time-resolved optical pumping experiments reveal strong electron–electron scattering resulting in an Auger-depleted zeroth order Landau level.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

During a pandemic, trust in leaders is affected by how they resolve moral dilemmas. Across 22 countries, leaders’ endorsement of instrumental harm reduced public trust, while endorsement of impartial beneficence increased trust.

Scanning tunnelling microscopy imaging of the correlated phases of magic-angle twisted trilayer graphene shows marked signatures of interaction-driven spatial symmetry breaking.

An autonomous DNA-origami nanomachine powered by the chemical energy of DNA-templated RNA-transcription-consuming nucleoside triphosphates as fuel performs rhythmic pulsations is demonstrated. In combination with a passive follower, the nanomachine acts as a mechanical driver with molecular precision.

Systematic phenotyping of 58,101 mutants of the model eukaryotic alga Chlamydomonas reinhardtii under 121 environmental and chemical stress conditions provides a large resource for characterizing gene function.

A chemical screen identified BET bromodomain inhibitors as promoters of keratinocyte regenerative function and skin wound healing. Specifically, low-dose transient treatment with BET inhibitors imposes an activated, migratory state in keratinocytes.

Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.

Pyroptosis has been implicated in many diseases with aberrant inflammation. Here, Kopp et al. characterize single-chain nanobodies targeting the human gasdermin D protein as tools to inhibit pyroptosis.

Multi-omics analyses of gut microbiome, liver and blood samples from patients with hepatitis C infection before and after removal of the virus reveal metabolic dysregulation along the gut–liver axis.

Single-molecule FRET studies of pre-mRNA dynamics within the spliceosome offer new insights into the mechanism of splicing by showing that Prp2 juxtaposes the 5' splice site and branch point elements, and that splicing factor Cwc25 enhances first step catalysis by stabilizing this proximal conformation.

Water condensation from air using intense, ultrashort laser pulses is demonstrated, an approach that could benefit remote sensing and studies in atmospheric science.

Unphosphorylated PINK1 of Pediculus humanus corporis forms a dimerized state before undergoing trans-autophosphorylation, and phosphorylated PINK1 undergoes a conformational change in the N-lobe to produce its phosphorylated, ubiquitin-binding state.

How do we make inferences about the source of sensory signals? Here, the authors use Bayesian causal modeling and measures of neural activity to show how the brain dynamically codes for and combines sensory signals to draw causal inferences.

There has been growing evidence that strategies to circumvent the barren plateau problem in variational quantum computing might also kill potential quantum advantages. In this Perspective, the authors gather this evidence, discuss what is still missing to provide a definitive answer, and provide new research directions.

New influenza virus vaccines tested in humans elicit broadly cross-reactive antibodies that bind the stalk of the viral hemagglutinin protein and may serve as templates to design a universal influenza vaccine.

In a mouse model for skin cancer, β-catenin signalling is shown to be important to specifically maintain a population of cancer stem cells. These cancer stem cells share properties with normal bulge stem cells and may therefore be derived from those cell. As β -catenin signalling isn't required for normal skin homeostasis, it may be a suitable new target for skin cancer therapy.

A cavity quantum electrodynamics system comprising a quantum emitter and an optical cavity is theoretically investigated. The outcoupling process for the N-photon state of the cavity is simulated. The numerical calculations predict the possibility of operating this system as a source of N-photon bundles with a tunable integer N.

Despite the efforts to tune their properties, the efficiency of tantalum nitride photoanodes falls short of the theoretical value. Here, a gradient Mg doping strategy is introduced to engineer tantalum nitride’s band structure and control its defects, leading to an applied bias photon-to-current efficiency of 3.25%.

The rotation of polarized light in certain materials when subject to a magnetic field is known as the Faraday effect. Remarkably, just one atomic layer of graphene exhibits Faraday rotations that would only be measurable in other materials many hundreds of micrometres thick.

Spin-polarized defects in 2D materials are attracting attention for future quantum technology applications, but their controlled fabrication is still challenging. Here, the authors report the creation and characterization of effective spin 1/2 defects via the atomically-precise generation of magnetic carbon radical ions in 2D WS₂.

Enterovirus HEV71 is responsible for recurring epidemics in developing countries. New structural analyses coupled with in silico docking methods have allowed for the generation of potent inhibitors of viral-envelope uncoating that block subsequent insertion of viral RNA into the host cell.

In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation. Here, the authors describe SiM-KARTS, a novel approach for detecting changes in the structure of single RNA molecules in response to a ligand.

The combined use of genome sequencing, cultivation and phenotypic characterization of 79 globally distributed strains from the bacterial phylum Planctomycetes sheds light on their varied cell shapes, modes of cell division and extensive signalling and metabolic potential.

Chlamydiae replicate in host cells within specialised vacuoles (inclusions), which are eventually ruptured to liberate the bacteria, leading to cell lysis. Here, Kerret al. use a laser ablation technique and videomicroscopy to show that inclusion rupture triggers a necrotic pathway in the host cell.

Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region.

Weyl semimetals are predicted to exhibit a host of unusual transport properties. NbP, a system predicted to share characteristics of both normal and Weyl semimetals, is now shown to have a very large, non-saturating magnetoresistance.

Genome-wide association analysis of irritable bowel syndrome identifies genetic susceptibility loci and highlights shared pathways with mood and anxiety disorders.

The ontogeny of conventional and plasmacytoid dendritic cells (DC) and how these two cell types are related is not fully known. Here the authors identify a pool of bone marrow precursor cells expressing Ly6D Siglec-H and Zbtb46 that can differentiate into either cDC or pDC and show that type I IFN can limit cDC and favor pDC output from these precursors.

Correlation-driven topological phases with different Chern numbers are observed in magic-angle twisted bilayer graphene in modest magnetic fields, indicating that strong electronic interactions can lead to topologically non-trivial phases.

Serpentinization systems of the Mariana forearc host chemosynthetic microbial life shaped by substrate availability and membrane adaptations, as revealed through geochemical and lipid biomarker analyses of sediment cores.