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Spent LiCoO₂ batteries pose challenges for sustainable recycling. Here, the authors develop a flash Joule heating method to upcycle spent LiCoO₂ into a sulfur-stabilized Li₆CoO₄ lithium donor, enabling efficient lithium replenishment and improving full-cell durability.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Enantiopure aliphatic amines are frequently encountered as chiral auxiliaries and synthetic intermediates for bioactive compounds. Here, the authors report a mild nickel-catalysed asymmetric reductive hydroalkylation to convert enamides and enecarbamates into α-branched chiral amines and derivatives.

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Plant intraspecific diversity genetic diversity could affect also other trophic levels. This meta-analysis shows that increasing plant genetic diversity improves the performance of plants and natural enemies of herbivores, while decreasing the performance of plant antagonists.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Global meta-analysis of plant species diversity effects on trophic levels of ecosystem functioning, finding beneficial impacts from increased diversity.

Cobalt-based subsurface dopants induce a shift in the rate-determining step of electrochemical CO₂ reduction on copper to the chemical step: OCCO* + H* → OCCHO* + *. Electrochemical production of ethylene over the optimized catalyst is achieved at low voltage and high current in a membrane electrode assembly system.

Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed behavioral changes in Mef2c-mutant mice.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

In a randomized controlled trial involving 2,185 participants, patient satisfaction was improved during interactions with receptionist nurses when assisted by a large language model, with significant reductions in negative emotions and repeated questions.

Current battery recycling processes face sustainability challenges. Using gas evolution in water electrolysis, this work realizes fast separation of active electrode materials from current collectors before their dry refabrication for electrodes without compromising performance.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Ultrasound-responsive liposomes integrating thylakoid fragments and encapsulating l-ascorbic acid can restore the antioxidant capacity of renal tubular cells via NAD⁺ biosynthesis and mitochondrial repair in animal models of acute kidney injury.

Early prediction of AKI-related clinical events and timely intervention for high-risk patients could improve outcomes. Here, the authors show a deep learning model that can identify patients with acute kidney injury (AKI) who are at high risk of death or dialysis at certain time points.

The recent observation of superconductivity in nickelate thin films has attracted a lot of attentions. Here, authors report single particle tunneling spectra on the superconducting nickelate thin films revealing two types of gap feature with one V-shape and the other a full gap.

Molecular representation learning is crucial for reliable molecular property prediction. Here, authors proposed a multi-channel learning framework for endorsing hierarchical chemical knowledge, enhancing the effectiveness and robustness.

An artificial ligament replacement is made from aligned carbon nanotubes formed into hierarchical helical fibres with nanometre and micrometre channels which are demonstrated for the replacement of anterior cruciate ligaments in both rabbit and ovine models, showing strong integration and functional recovery.

EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.

The large-scale fabrication of twisted van der Waals heterostructures remains challenging due to the formation of defects and contaminations during the transfer process. Here, the authors report a transfer method to fabricate graphene-based van der Waals superlattices at the wafer scale, showing controllable twist angles and robust quantum Hall effect.

Efferocytosis inhibition leads to the release of immunogenic contents into the tumor microenvironment. Here the authors developed a nanosystem that inhibits MerTK-mediated efferocytosis and captures tumor-associated agents to enhance antitumour immunity.

The magnetic anisotropy of the van der Waals ferromagnet Fe₅GeTe₂ can be continuously tuned—from an initial out-of-plane orientation to a canted orientation and then finally to an in-plane orientation—using electrical gating.

Enantioselective C(sp³)–C(sp³) coupling plays an important role in organic synthesis, but limitations remain. Now, cobalt-catalysed enantioselective C(sp³)–C(sp³) coupling between achiral fluoroalkenes and alkyl halides enables the streamlined and auxiliary-free synthesis of chiral fluoroalkanes.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Illuminating internal organs and tissues with high controllability and adaptability remains challenging. Here the authors present a flexible, biodegradable photonic device called iCarP for large area, high intensity, wide spectrum, deeply penetrating, continuous or pulsatile illumination.

The discovery of highly enantioselective catalysts is challenging due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods. Here, the authors report a general strategy for ultra-high-throughput mapping of the chemical space of asymmetric catalysis with a combination of ion mobility-mass spectrometry and a diastereoisomerization strategy and identify enantioselective primary amine organocatalysts using this method.

Integration of data from single-cell RNA-seq and ATAC-seq is achieved with transfer learning.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.