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Colloidal quantum rods can emit polarized light but suffer from uneven shell growth. Here, the authors employ a dual-ligand strategy to selectively grow compositionally graded shells in radial thickness, yielding LEDs with an efficiency of 32%.

This study achieves high-density potassium niobate ceramics via hot-pressing. It identifies a unique intragranular pore-evolution mechanism driven by lattice diffusion, revealing how these pores dictate the material’s chemical stability.

Using cryo-EM, researchers solve the structure of the TRPC1/5 ion channel complex, revealing a unique drug-binding pocket. This enables design of JD03-02, a selective inhibitor with potential to treat anxiety and depression.

In this work, the authors show that the uncharacterized protein YchJ acts as a ROS-sensing transcription factor in Salmonella; upon oxidation, YchJ dimerization represses rssB, stabilizing RpoS to activate antioxidant enzymes, protecting the pathogen from macrophage oxidative burst.

Control of the arrangement of anisotropic units allows for control of properties. Authors achieve direction tailoring of 2D anisotropic sheets by multiflow technique, offering a mortise-and-tenon-like vdW joint model for strengthening and toughening in graphene

Ketogenic diet (KD) generates β-hydroxybutyrate metabolites and has been shown to have context-dependent immunomodulatory effects. However, the effects of KD on inflammatory bowel disease (IBD) are controversial. Here, the authors investigate the pathogenic effects of KD in a preclinical model of DSS-induced colitis and identify a β-HB-Thomasclavelia spiroformis-γδ17 T cell axis that exacerbates inflammation and mucosal damage.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Lipoatrophy is a feature of premature aging, including in a rare genetic form of premature aging caused by a mutation in A-type lamin gene (Lmna). Here the authors report that adipocyte-specific expression of the LmnaG609G mutation leads to progressive white adipose tissue atrophy, accelerated aging and shortens lifespan mediated by cyclooxygenase-2 in male mice, whereas female mice remain unaffected.

The contribution of variations within accessible chromatin regions (ACRs) to heterosis is not well understood. This study profiles chromatin accessibility in maize inbreds and their reciprocal F1 hybrids, showing that overexpressing a candidate rhamnosyl transferase gene in a hybrid chromatin context increases plant height.

Here the authors report that WNT10B, a ligand of the Wnt family, mediates renal inflammation and fibrosis. Mechanistic work in male mice with induced chronic kidney disease shows that the WNT10B/FOXO6 axis controls tubular senescence fate transition and pro-inflammatory microenviroment formation through metabolic reprogramming.

Hypoxia triggers distinct epidermal and dermal metabolic responses, driving skin organoids from spherical aggregates to planar embryonic-like structures. This reveals how cells use low oxygen to construct functional tissue.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Electric-field-controllable, stochastic alteration of multiple conductance states in a Sc₂C₂@C₈₈ cluster is observed. A matrix-chain multiplication of two 4 × 4 state-transition matrices is demonstrated using this cluster with maximum error of less than 0.05.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Arctic shipping is increasing owing to sea ice melt offering more efficient alternatives to traditional shipping routes, leading to negative impacts across the atmosphere, cryosphere, hydrosphere and biosphere. This Review discusses the factors influencing trends in Arctic shipping, the associated environmental impacts and potential pathways towards sustainable solutions.

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threats to marine biosecurity.

Microalgae‑based hydrogen production faces challenges including oxygen sensitivity, high water demand, and low efficiency. The authors develop a symbiotic hydrogel system that enhances hydrogen production by using coaxial 3D bioprinting to spatially separate microalgae and bacteria.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

The enhancement of tribo-negative performance in traditional fluorinated polymers is important for the design of triboelectric devices. Here, the authors describe the enhancements of the tribo-negative properties of fluorinated copolymers via the synergistic effects of C-F and C-Cl bonds in the polymers.

Substrates with blastocyst-like microstructures effectively revert primed pluripotent stem cells to naivety by promoting cell–cell apical constriction and mechanoinduced epigenetic activation of naive pluripotency genes.

This study shows that greening peri-urban areas boosts rainfall within cities, revealing their hidden role in shaping intra-urban precipitation and supporting climate-resilience planning.

The irradiation of crystalline materials is known to create various types of lattice defects, which can degrade mechanical performance. Here, Xu et al. observe the in-situnucleation and growth of atomic-scale voids in magnesium during electron irradiation.

Room-temperature multiferroic materials are highly demanded for designing next-generation of spintronic devices. Here, the authors demonstrate an emergent room-temperature ferrimagnetism and polar phase in highly strained La₂CoRuO₆ epitaxial films through engineered 3d−4d cation ordering.

Pyroptosis is a programmed cell death controlled by complex pathways, making it hard to induce selectively for targeted cell elimination. Here, the authors developed DAMAGE, a system that combines pyroptosis with type III-E CRISPR to detect specific RNA and trigger cell death

EGFR-targeted therapy is often used in patients with EGFR-driven cancer but is limited by on-target/off-tumor toxicities. Here, the authors develop a bispecific antibody targeting both EGFR and B7-H3 and demonstrate improved EGFR targeting and tumor selectivity in preclinical models of multiple solid tumors.

Accurately assessing the sustainability of grassland ecosystems affected by grazing is challenging at the continental scale. Using the developed alert index, this study suggests that 51.02% of grasslands exceed their carrying capacity, while 26.53% remain underutilized.

Conventional carbon synthesis is energy intensive. Here, the authors introduce an energy-autonomous pathway using polyaniline-HClO₄ composites. This rapid reaction yields carbon nanosheets with tunable active sites for electrocatalysis.

This study identifies an autocrine role for hepatic FGF1, wherein its circadian rhythmicity synchronizes triglyceride secretion with activity. Disruption of this clock-regulated pathway impairs lipid homeostasis.

Beta-hydride elimination is a crucial elementary step in transition-metal catalysis, but controlling the stereochemistry of this process has been underdeveloped. Here, the authors report a Trost-ligand-enabled enantioselective desymmetric beta-hydride elimination reaction from π-allyl-palladium species, providing rapid access to cyclohexenes bearing a remote C4 stereocenter.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

DNA double-strand breaks are primarily repaired by non-homologous end joining, which requires synapsis of broken DNA ends. Here, the authors show that DNA end configurations, particularly short microhomologies, dictate synaptic complex formation and can bypass XLF to promote close end joining.

The efficiency of selenium photovoltaics is hindered by the poor crystallization of the Se film. Wen, Li, Lu and colleagues use light to initiate Se crystallization, suppressing dewetting and enabling the formation of a continuous film, which achieves a certified efficiency of 10.3%.

To establish metastasis, cancer cells need to adapt in order to navigate through confined spaces. Here, the authors discover that compression force-induced CSK23-mediated NF-κB activation regulates ALDH1B1 expression, ultimately modulating ferroptosis and tumor cell survival in confining capillaries.

Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF₃Et₂O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF₃·Et₂O as the fluorine reagent in the presence of chiral iodine catalyst.

This study highlights the Wheat Spatial Omics Consortium, which aims to build a spatiotemporal single-cell atlas of wheat in response to different treatments, thereby contributing to the development of sustainable and climate-resilient wheat.

Terahertz (THz) pulses are generated by irradiating a metal wire with femtosecond laser pulses. For incident laser energy of 3 mJ, a THz pulse with energy of 28 μJ is obtained from a 10-cm-long wire. The spectrum of the THz pulse covers 0.1–1.5 THz.